Application of Platycodon grandiflorum total saponins in the treatment and prevention of mycoplasma pneumoniae infectious diseases

Abstract

The invention relates to application of a platycodon root total saponin to medicaments for treating and preventing mycoplasma pneumoniae infectious diseases, and relates to application of platycodon root total saponin to medicaments. The platycodon root total saponin is used as the active ingredient of the medicaments for treating and preventing the mycoplasma pneumoniae infectious diseases, and is a composition of one or more of saponins of platycogenic acid, polygalic acid, platycogenic acid and platycogenic acid A lactone. The platycodon root total saponin has the effect of resisting mycoplasma pneumoniae; in-vitro experiments indicate that a minimal inhibitory concentration (MIC) value of resisting mycoplasma pneumoniae (MP) is between 16 and 64 mu g / ml, and the minimal bactericidal concentration (MBC) is between 64 to 128 mu g / ml; and in-vivo experiments indicate that after 8 mg / Kg and 16 mg / Kg of platycodon root total saponins are subjected to intragastric administration on BALB / C mice subjected to MP injection by nasal dropping for 10 days, the pathological injury of lungs of the mice can be relieved obviously, and the immunologic function of organisms is regulated, so the platycodon root total saponin has a treatment effect on the MP infection.

Description

technical field [0001] The invention relates to the application of total platycodon saponins in medicine. Background technique [0002] Bellflower is the root of Platycodon grandiflorum (Jacq.) A.DC., a plant in the Campanulaceae family. It is a traditional Chinese medicine in my country with a long history of medicinal use and is widely used. Its taste is bitter, pungent, and neutral in nature. Mainly returns to lung meridian. It has the effects of clearing the lung, resolving phlegm, relieving the throat, and evacuating pus. It is mainly used clinically for the treatment of cough with excessive phlegm, chest tightness, hoarseness of the throat, pulmonary abscess and vomiting of pus. The modern research on Platycodon grandiflora began in the 1940s, and its main active ingredient is oleanolic acid-type pentacyclic triterpene saponins. Scholars at home and abroad have found that the total saponins of platycodon grandiflora have anti-oxidation, anti-inflammatory and analges...

AI Technical Summary

Problems solved by technology

[0006] In the treatment of livestock MP infection, due to the long course of treatment for MP infection (about 2 weeks), long-term use of antibiotics will cause a large amount of accumulation in the animal body, resulting in antibiotics in animal muscle, fat, viscera and other tissues and by-products such as milk and eggs. Exceeding the standard will directly affect the economic benefits

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