Application of polypeptide in preparing medicine for treating enterovirus infection

An enterovirus and drug technology, which is applied in the field of peptides in the preparation of drugs for treating enterovirus infection, can solve problems such as no treatment for enterovirus infection, and achieves the promotion of ulcer healing, good water retention, and good effect. Effect

Active Publication Date: 2017-05-17
ZHEJIANG ECHON BIOMEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The applicant discovered the polypeptide of the present invention in research, which is an antimicrobial peptide, and has applied for a number of patents on its antimicrobial and other properties before. The prior art only reports the antibacterial performance of the polypeptide, and no See its report on the treatment of enterovirus infection

Method used

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  • Application of polypeptide in preparing medicine for treating enterovirus infection
  • Application of polypeptide in preparing medicine for treating enterovirus infection
  • Application of polypeptide in preparing medicine for treating enterovirus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 Preparation of lyophilized formulation of the present invention

[0033] Dissolve the auxiliary materials mannitol and arginine, mix them with the polypeptide of the present invention, adjust the pH value to 7.2, and form a composition containing 1 mg of the polypeptide, 32 mg of mannitol, and 15 mg of arginine per milliliter of liquid. After filtering and sterilizing, freeze Drying is a freeze-dried preparation.

Embodiment 2

[0034] Embodiment 2 The preparation of spray according to the present invention

[0035] For the convenience of transportation and storage, the polypeptide of the present invention is prepared into a freeze-dried preparation, which can be prepared as a spray preparation according to the needs during use: the freeze-dried preparation is dissolved with physiological saline or a common medical solvent, and the concentration range of the polypeptide after dissolution is 0.01%, put it into a sprayer that meets the requirements, and it can be sprayed and used.

Embodiment 3

[0036] Embodiment 3 The preparation of lotion of the present invention

[0037] Stir 8% glycerin in purified water evenly, add 0.02% of the polypeptide, 0.5% arginine and 10% lysine to mix, stir evenly and adjust the pH to 7.2 to obtain the peptide lotion.

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PUM

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Abstract

The invention discloses application of polypeptide in preparing a medicine for treating enterovirus infection, belongs to the field of infectious disease prevention and treatment, further provides a medicinal composition for treating enterovirus infection, and in addition, provides a polypeptide preparation prepared from pharmaceutically acceptable auxiliary materials or auxiliary components. The medicinal composition comprises an effective dosage of the polypeptide as an active component. The polypeptide disclosed by the invention can be used for treating enterovirus infection, particularly for treating and preventing hand-foot-mouth diseases and herpetic herpangina, and is remarkable in effect and good in security.

Description

technical field [0001] The invention relates to the field of treatment of enterovirus infection, in particular to the use of a polypeptide in the preparation of medicines for treating enterovirus infection. Background technique [0002] Enteroviruses (Enteroviruses, EVs) are a class of pathogens that invade and multiply in intestinal cells, which can induce various inflammations in human intestinal epithelial cells. Enteroviruses belong to the genus Enterovirus of the family Picornaviridae, including poliovirus (PV), Echovirus (Echovirus), Coxsackievirus (CVA, CVB), and new enteroviruses, a total of 106 serum type. According to biological and genetic characteristics, it is divided into 4 groups (species) (Kenowles NJ, Hovi T, Hyypia T, et al. Classification and nomenclature of virus: ninth report of the international committee on taxonomy of viruses. San Diego: Elsevier, 2011): Enterovirus A (EV-A) includes 21 serotypes, Enterovirus B (EV-B) includes 60 serotypes, and Ente...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61P1/00A61P31/12A61P31/14
CPCA61K38/10
Inventor 凌建群章殷捷
Owner ZHEJIANG ECHON BIOMEDICAL CO LTD
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