Filling and disinfecting method for sodium bicarbonate injection in glass transfusion bottle

Abstract

The invention provides a method for filling and sterilizing sodium bicarbonate injection filled in glass infusion bottles, and relates to the field of liquid storage and filling, in particular to a method for solving the problem that bottle mouths are loosened and bottles are exploded in the sterilization process of the sodium bicarbonate injection filled in glass infusion bottles. The method comprises the following steps: (1) qualified 5 percent sodium bicarbonate injection prepared according to a production formula is filled in clean glass infusion bottles, the filling amount in each bottle takes ml or L as unit, and the ratio of the volume of the sodium bicarbonate injection to the volume of the glass infusion bottle is between 1:1.25 and 1:2.40; (2) corks and cops are arranged according to common production process; and (3) sterilization is performed for 30 minutes at the sterilization temperature of 115 DEG C. The method has the advantage that the method can effectively control the phenomena of loosened bottle mouths and exploded bottles in the sterilization process of the sodium bicarbonate injection filled in the glass infusion bottles, and ensures that the sterilization process meets the sterility requirement.

Description

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AI Technical Summary

Benefits of technology

This patented technology uses two types of materials - one with high water solubility (NaBCO3) while another material has low hydrophobicity or does not dissolve easily when mixed together. By adjusting these properties during manufacturing processes, it helps prevent problems such as loose plugs that may occur if too much salt solution enters into certain parts of the container used by patients who are taking their medicine due to insufficient saline content inside them' veins caused by poorly controlled ingredients added through an IV tube inserted into patient blood vessels. Additionally, this design allows for better control over the final dosage form produced without adding excessive liquid.

Problems solved by technology

This patented technical problem addressed by this patents relates to improving the stability and reliability of injectable substances during storage without causing damage caused by excessive pressure on certain parts such as valves that control flow through an IV tube system.

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