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Infiltrative breast carcinoma recurring risk assessment kit

A technology of risk assessment and kit, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problem of short maintenance time and achieve reliable results

Inactive Publication Date: 2009-05-06
PEKING UNIV THIRD HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current research on cyclin A2 believes that cells can enter the S phase after receiving various stimuli. When entering the cell cycle, it begins to increase 16 hours after entering the cell cycle, and begins to decrease after 24 hours. The maintenance time is short, and cyclin A2 is closely related to cell canceration.

Method used

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  • Infiltrative breast carcinoma recurring risk assessment kit
  • Infiltrative breast carcinoma recurring risk assessment kit
  • Infiltrative breast carcinoma recurring risk assessment kit

Examples

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Embodiment 1

[0015] Example 1. Using the Invasive Breast Cancer Recurrence Risk Assessment Kit to Assess the Risk of Invasive Breast Cancer Recurrence

[0016] 1. Cyclin A2 as a molecular marker to predict breast cancer recurrence risk

[0017] 1) Gene chip analysis

[0018] From the breast cancer tissue specimen bank established by Peking University Third Hospital in 2003, the tissue specimens of 6 patients with invasive breast cancer that recurred within 3 years were selected as the recurrence group, and the pathological types, treatment methods and epidemiology of 6 cases were selected. Similar patients with the same characteristics but no recurrence for more than 3 years were the non-recurrence group, and the normal breast tissue collected from the other 5 cases during benign breast disease surgery was the normal control group. The specimens were processed as follows: Put liquid nitrogen in it, ②To ensure that the tumor tissue was collected, each tissue section was stained with HE and...

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Abstract

The invention discloses an agent box for evaluating the recurrence risk of infiltrating breast cancer, which is an immunohistochemistry agent box and comprises a Cyclin A2 monoclonal antibody, an HRP-labeled goat anti-rabbit or goat anti-mouse IgG polymer, goat serums, a polymer helper, a sensitized diaminobenzidine colour development agent box and hematoxylin. The agent box for evaluating the recurrence risk of infiltrating breast cancer adopts the technical proposal for evaluating the recurrence risk of infiltrating breast cancer that mammary tissues are processed into paraffin sections, and the expression amount of cells in different parts can be accurately observed, thus results can be much more reliable.

Description

technical field [0001] The invention relates to a kit for assessing the recurrence risk of invasive breast cancer. Background technique [0002] A large number of studies have found that there are very small amounts of estrogen receptor (Estrogen receptor: ER) and progesterone receptor (Progesterone receptor; PR) in normal breast tissue, which are proteins with high affinity. Clinically, through the detection of estrogen receptor (ER) and progesterone receptor (PR), the level of hormone receptor content in tumor cells can be obtained, so as to prompt the prognosis information of breast cancer and guide endocrine therapy. It is reported that the positive rates of breast cancer ER and PR detection are about 40%-60% and 30% respectively. Many literatures have confirmed that ER and PR changes are closely related to the prognosis of breast cancer patients, and are also related to other recognized prognostic factors, such as nuclear grade, lymph node metastasis and stage. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/577
Inventor 李惠平季加孚侯宽永雷玉涛
Owner PEKING UNIV THIRD HOSPITAL
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