Unlock instant, AI-driven research and patent intelligence for your innovation.
Application of pueraria flower glucoside in preparation of medical compound for remedying osteoporosis
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
An osteoporosis and composition technology, which is applied to the application field of plant extract puerarin in the preparation of new drugs, can solve the problems of affecting drug availability and significant time, low water solubility, and inconvenient selection and use.
Inactive Publication Date: 2010-12-29
INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
View PDF2 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0007] Due to the low water solubility of puerarin, when it is used as medicine, it can only be made into oral preparations and cannot be made into injections. Because of their low water solubility, it affects the drug availability and significant time, and is not convenient for clinical selection.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0086] Embodiment 1. The preparation of puerarin
[0087] In this example, 10 kg of dried Pueraria mirifica was crushed, extracted twice with 90% ethanol solution under reflux, each time for 3 hours, filtered, the filtrate was collected, the ethanol was recovered until there was no alcohol smell, 6 times the amount of water was added to the solution, and left overnight , take the supernatant. Pass through the macroporous resin, elute with 60% ethanol, recover the eluent, place it to precipitate crystals, filter, dry, recrystallize with acetone, and filter to obtain pueraria glycoside.
example 2
[0089] Taking the preparation of 1000 puerarin injections as an example, the ratio of raw materials and auxiliary materials used is as follows:
[0090] Pueraria glycosides 100g
[0091] Hydroxypropyl-β-cyclodextrin 500g
[0092] Sodium Calcium Edetate 1g
[0093] Sodium bisulfite 10g
[0094] Add water for injection to 10L
[0095] It is made by the conventional injection preparation process, and each bottle weighs 10 orders and 10ml, and each bottle contains 100mg of puerarin. Usage: Once a day for adults, 6 vials for intravenous injection each time, reduce the dose for children as appropriate.
example 3
[0097] Taking the preparation of 100ml of puerarin injection, 1000 bottles as an example, the ratio of raw materials and auxiliary materials used is as follows:
[0098] Pueraria glycosides 1000g
[0099] Hydroxypropyl beta cyclodextrin 3000g
[0100] Sodium Calcium Edetate 1g
[0101] Sodium bisulfite 10g
[0102] Add water for injection to 10L
[0103] It is made by the conventional injection preparation process, and each bottle is 100ml, and each bottle contains 1mg of puerarin. Usage: Adults 1 time a day, 1 bottle of intravenous injection each time, children reduce the dose as appropriate.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention relates to pueraria flower glucoside which is extracted from pueraria flower and can be used for preparing a medical compound for remedying the osteoporosis. The medical compound contains the pueraria flower glucoside and a pharmaceutically acceptable carrier. 0 percent to 50 percent of solubilizer is added into the medical compound of the pueraria flower glucoside, such as hydroxypropyl-beta-cyclodextrin, beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin and the like can improve the water-solubility of the pueraria flower glucoside obviously, thereby improving the bioavailability of the pueraria flower glucoside. The medical compound of the pueraria flower glucoside containing the solubilizer can be directly made into an injection preparation used for remedying the osteoporosis.
Description
[0001] This application is a divisional application of <<Pharmaceutical Composition of Pueraria Gin and Its Application>> invention patent application, the original name of the invention is <<Pharmaceutical Composition of Pueraria Gin and Its Application>>, and the original application date was 2005 On July 4, the application number was 200510043968.3. technical field [0002] The invention relates to the field of traditional Chinese medicines, and relates to the application of a plant extract puerarin in the preparation of new medicines. Background technique [0003] Flos Puerariae, also known as Pueraria Lobata (Willd.) Ohwi, is the dried flower bud of Pueraria Lobata (Willd.) Ohwi, a plant of the family Leguminosae. Cool in nature, sweet in taste, enters Gui Yang Ming Jing. "Shen Nong's Materia Medica", "Compendium of Materia Medica", etc. record that it has the effect of relieving alcohol and refreshing the spleen. [0004] According to literatu...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P19/10
Inventor 仲英左春旭王元书刘鲁解砚英王菊孙敬勇
Owner INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
Login to View More 
Login to View More