Copolymer of fibroin and poly L-lactic acid, solid phase polymerization preparation method and application thereof

Abstract

The invention discloses a copolymer of fibroin and a poly L-lactic acid. The molecular weight of the copolymer having the structure is 5,000-200,000, and the mass ratio of the fibroin chain segment and the poly L-lactic acid chain segment is 1 / 99-99 / 1. The invention also discloses a solid phase polymerization preparation method thereof and the application thereof in biomedical materials. The invention adopts the method of direct polymerization, the copolymer of fibroin and the poly L-lactic acid is prepared through main body melt / solid phase polymerization, and solvent is not used in the synthesis technique; therefore, the invention has the advantages that the process is simple, the product cost is low, the production cycle is short, and no pollution is generated. Through the invention, copolymer of fibroin and poly L-lactic acid with different number average molecular weight can be prepared, with the molecular weight of 5,000-200,000. Copolymer of fibroin and poly L-lactic acid prepared through the invention can improve the hydrophilicity, the biocompatibility and the cellualar affinity of lactic acid material and control the degradation speed of the material.

Description

Technical field: The invention belongs to the technical field of polymer materials, and in particular relates to a copolymer of silk protein and poly-L-lactic acid, a preparation method and application thereof. Background technique: Polylactic acid (PLA) is a biodegradable and absorbable polymer material with good biocompatibility. It has the advantages of good biocompatibility, degradation products can participate in the metabolism of the human body, and low toxicity. It has been widely used in tissue engineering and other biomedical fields. However, polylactic acid also has performance defects, such as greater brittleness, lower mechanical strength, and difficulty in controlling the degradation cycle. In addition, PLA is a hydrophobic polymer with poor adhesion to cells. Pure polylactic acid as a tissue engineering material will cause some mild inflammatory reactions after implantation into the organism, so the polylactic acid material must be modified. Therefore, in or...

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