Application of medlar in preventing urinary calculus

A technique for urolithiasis and wolfberry, which is applied in the application field of wolfberry in preventing urolithiasis

Inactive Publication Date: 2009-07-15
上海交通大学医学院附属第三人民医院
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As for whether wolfberry can effectively resist the cytotoxicity of high-concentration urinary oxalic acid and reduce the damage of renal tubular epithelial cells through its antioxidant effect, so as to prevent the formation of renal calcium oxalate stones, there is no relevant report yet.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of medlar in preventing urinary calculus
  • Application of medlar in preventing urinary calculus
  • Application of medlar in preventing urinary calculus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] In the formation of stones, adhesion of crystals to the renal tubules is a necessary part. Damage to renal tubular epithelial cells can significantly promote the adhesion of crystals, and peroxidation damage is the main mechanism leading to the injury of renal tubular epithelial cells induced by high oxalate. If it can effectively prevent or reduce the damage of urinary oxalic acid to renal tubular epithelial cells, it will help prevent renal calcium oxalate stones. Studies have found that Lycium barbarum polysaccharide, the main active component of Lycium barbarum, can directly scavenge free radicals in vitro, and can inhibit the spontaneous or free radical-induced lipid peroxidation reaction, and has a certain cytoprotective effect. The present invention shows that Lycium barbarum polysaccharides are tested in vivo by animals It can effectively antagonize the cytotoxicity of high-concentration urinary oxalic acid and reduce the formation of calcium oxalate stones in the k...

Embodiment 2

[0063] Because the main active ingredient in wolfberry is wolfberry polysaccharide. The present invention uses different concentrations of wolfberry infusions and decoctions to study and compare the intervention effects, and finds that they can effectively inhibit the formation of kidney calcium oxalate stones in rats drinking the stone attractant.

[0064] 1. Materials and methods

[0065] 1. Animal grouping and administration method

[0066] Choose from 80 healthy and clean adult male SD rats provided by the Department of Laboratory Animal Science of Fudan University, weighing 160-200g, and randomly divided into 8 groups, each with 10 rats. They were fed adaptively in the same environment for 1 week, and then treated as follows 4 weeks: Group A (blank control group): drink deionized water; Group B (simple stone-inducing group): 1% ethylene glycol solution as the only drinking water source; Group C to E (inducing stone + different concentrations of wolfberry Soaking agent group):...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides the application of medlar for preventing urinary calculus. The main active component in medlar is wolfberry polysaccharide which has oxidation resistance action and can clear free radical in a body. Experiments show that proper amount of wolfberry polysaccharide can reduce the formation of renal calcium oxalate in bodies of rats which drink stone inducement agents. The wolfberry polysaccharide has the action mechanism that free radical can reduce the damage to nephridial tissues through oxidation resistance reaction so as to reduce the apoptosis of renal tubule epithelium, therefore, the invention has efficacy for preventing urinary calculus, and also has important application in the field of medicine, food and health products. Medlar has the characteristics of various obvious health function and the homology of medicine and food, has low cost, is convenient to take, and has high compliableness degree for patients. In addition, medlar belongs to natural substances and has no side effect.

Description

【Technical Field】 [0001] The invention discloses the application of lycium barbarum polysaccharides in preventing urinary calculus diseases, especially the application of preventing urinary calculus in the production of medicines, foods and health products. 【Background technique】 [0002] Urolithiasis is a global disease and one of the most common urology diseases. The high recurrence rate of urolithiasis has been plagued by patients and doctors. Because the mechanism of urolithiasis is very complicated, the prevention research progress is very slow. . [0003] The traditional view is that oxalic acid participates in the formation of kidney stones in the form of calcium oxalate crystals. Therefore, early studies only concerned about the effects of urine pH, ionic strength and various proteins on the formation of calcium oxalate crystals. The latest research shows that renal tubular epithelial cell injury is the earliest basic pathological change in the formation of stones. [000...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P13/04
Inventor 张士青厉建李文峰
Owner 上海交通大学医学院附属第三人民医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap