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Chinese medicinal composition for resolving phlegm and suppressing cough as well as preparation method and quality control method thereof

A technology for relieving cough and reducing phlegm, composition, applied in the field of traditional Chinese medicine composition and its preparation method and quality control, capable of solving problems such as addiction

Active Publication Date: 2009-08-05
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the medicines for eliminating phlegm and relieving cough, Western medicine and Chinese patent medicine have their own strengths: Western medicine is directly symptomatic and quick to take effect, but it is addictive and often needs to be combined with other medicines for comprehensive treatment. Anti-cold drugs need to be used in combination; commonly used Chinese patent medicines have definite curative effects if used symptomatically.

Method used

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  • Chinese medicinal composition for resolving phlegm and suppressing cough as well as preparation method and quality control method thereof
  • Chinese medicinal composition for resolving phlegm and suppressing cough as well as preparation method and quality control method thereof
  • Chinese medicinal composition for resolving phlegm and suppressing cough as well as preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0047] Experimental example 1 Pharmacodynamic study of the pharmaceutical composition of the present invention

[0048] 1 material

[0049] 1.1 Drugs The drug group I of the present invention is obtained according to the method of Example 6; the drug group II of the present invention is obtained according to the method of Example 7; the drug group III of the present invention is obtained according to the method of Example 8; Cough syrup; codeine phosphate tablets; ammonium chloride; ammonia water; all reagents used are of analytical grade.

[0050] 1.2 Animals NIH mice, frogs.

[0051] 1.3 Statistics The t test between groups was used for comparison.

[0052] 2 methods

[0053] 2.1 Antitussive effect

[0054] 2.1.1 Effects on cough induced by ammonia water

[0055] Choose 18-22g mice (spray for 20s, make the mice cough more than 25 times / 30s is qualified), male and female are divided into 5 groups randomly, ig administration (the first group, equal volume of distilled wat...

experiment example 2

[0083] Experimental example 2 Research on the inhibitory effect of the drug group of the present invention on cytochrome P450 (CYP3A4 and CYP1A2)

[0084] The medicine group of the present invention is an antitussive medicine prepared from various traditional Chinese medicine ingredients such as Huajuhong, Aracea, orange peel, etc., and is widely used clinically because of its good effect of eliminating phlegm and relieving cough. The medicine group of the invention contains various chemical components such as flavonoids hesperidin, citral and monoterpene compounds. CYP3A4 is an important cytochrome P450 that catalyzes the metabolism of 60% of clinical drugs.

[0085] During the experiment, we surprisingly found that the drug group of the present invention has an inhibitory effect on CYP3A4 and CYP1A2, resulting in adverse drug interactions with catalytically metabolized drugs.

[0086] Materials and Methods

[0087] 1. Materials

[0088] The pharmaceutical group of the pre...

experiment example 3

[0109] Experimental example 3 Ophiopogon japonicus identification test screening

[0110] (1) Preparation of test solution

[0111] Method 1: take the pharmaceutical preparation of the present invention equivalent to 24.08g of the original medicinal material, grind it finely, add 3ml of hydrochloric acid, heat it in a water bath for 0.5 hours, let it cool, add 30ml of diethyl ether to shake and extract, divide the diethyl ether solution, evaporate to dryness, add three Dissolve in 1ml of methyl chloride as the test solution.

[0112]Method 2: take the pharmaceutical preparation of the present invention equivalent to 24.08g of the original medicinal material, grind it finely, add 3ml of hydrochloric acid, heat it in a water bath for 1 hour, let it cool, add 30ml of diethyl ether to shake and extract, divide the diethyl ether solution, evaporate to dryness, add three Dissolve in 1ml of methyl chloride as the test solution.

[0113] Method 3: take the pharmaceutical preparation...

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Abstract

The invention relates to a Chinese traditional medicine composition for relieving cough and reducing sputum, a method for preparing the same and a method for controlling the quality. The Chinese traditional medicine composition comprises bulk drugs of pummelo peel, dried orange peel, rhizoma pinellinae praeparata, coltsfoot flower, balloon flower, bitter apricot kernel (fried without peel), tuckahoe, trichosanthes bark, liquorice, aster, dwarf lilyturf root, rhizoma anemarrhenae, radix rehmanniae, gypsum, perilla seed (fried), and the like which are added with auxiliary materials and are prepared into clinically acceptable dosage forms including capsules, soft capsules, pills, tablets, powder, injections, granules, mixtures, and the like. The quality control method for the Chinese traditional medicine composition identifies the dwarf lilyturf root, the liquorice, the bitter apricot kernel, the dried orange peel, the balloon flower and the trichosanthes bark, performs content determination on the pummelo peel, and ensures the curative effect of the medicine. The Chinese traditional medicine composition has the efficacy of relieving cough and reducing sputum, and is applied to treating cough with more sputum, fullness sensation in chest with short breath, and dry pharynx and tickling throat caused by phlegm heat lung obstruction.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, a preparation method and a quality control method thereof, in particular to a traditional Chinese medicine composition for relieving cough and reducing phlegm, a preparation method and a quality control method thereof. Background technique [0002] From a physiological point of view, coughing is a protective activity for the body. It can expel sputum and foreign matter in the respiratory tract, thereby keeping the respiratory tract clean and unobstructed, which is beneficial to health. But more frequent and severe cough will affect people's work, life and study. At this time, symptomatic cough-relieving and phlegm-reducing drugs should be selected according to the symptoms. Some serious diseases are often accompanied by cough symptoms, such as pleurisy, spontaneous pneumothorax, tuberculosis, lung cancer, heart failure, etc., all of which will cause cough. Among the medicines for eli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K36/904A61K36/899A61K9/10G01N30/90G01N30/02A61P11/10A61P11/14A61K33/06
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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