Effervescence tablet capable of treating penis erection dysfunction and preparation method thereof

A technology for erectile dysfunction and effervescent tablets, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of single varieties, inconvenient taking methods, and large toxic and side effects of drugs, etc. problems, to achieve the effect of easy portability, rapid drug onset and high bioavailability

Active Publication Date: 2011-05-04
李浪辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drugs used to treat ED are of a single variety and their efficacy is not clear, and they are generally temporary supplies
However, the existing drugs have relatively large toxic and side effects and cannot be used for a long time; the disintegration time is long, the taking method is inconvenient, and the drug effect cannot be fully exerted.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Sildenafil citrate 500g, lactose 450g, microcrystalline cellulose 300g, citric acid 300g, sodium bicarbonate 450g, hydroxymethyl starch sodium 150g, flavoring agent 25g, micropowder silica gel 25g, stevia 25g, Polyethylene glycol 275g;

[0039] (2) After melting the polyethylene glycol of 137.5g, add 450g of sodium bicarbonate, stir evenly, cool and pulverize, pass through a 100-mesh sieve, and set aside;

[0040] (3) Pulverize 500g of the sildenafil citrate crude drug, and cross a 100-mesh sieve for subsequent use;

[0041] (4) 450g of lactose, 300g of microcrystalline cellulose, 300g of citric acid, 150g of sodium hydroxymethyl starch, 25g of flavoring agent, 25g of stevioside, mixed and pulverized, passed through a 100-mesh sieve for later use;

[0042] (5) Pulverize 25g of micropowder silica gel, and cross a 100-mesh sieve for subsequent use;

[0043](6) Mix the fine powders of (2), (3) and (4), add 137.5g polyethylene glycol anhydrous ethanol solution to make...

Embodiment 2

[0045] (1) Sildenafil citrate 500g, lactose 425g, microcrystalline cellulose 300g, citric acid 300g, sodium bicarbonate 500g, hydroxymethyl starch sodium 200g, flavoring agent 25g, micropowder silica gel 25g, stevioside 25g, Polyethylene glycol 200g;

[0046] (2) After melting 100g of polyethylene glycol, add 500g of sodium bicarbonate, stir evenly, cool and pulverize, pass through a 100-mesh sieve, and set aside;

[0047] (3) Pulverize 500g of the sildenafil citrate crude drug, and cross a 100-mesh sieve for subsequent use;

[0048] (4) 425g of lactose, 300g of microcrystalline cellulose, 300g of citric acid, 200g of sodium hydroxymethyl starch, 25g of flavoring agent, 25g of stevioside, mixed and pulverized, passed through a 100-mesh sieve for later use;

[0049] (5) Pulverize 25g of micropowder silica gel, and cross a 100-mesh sieve for subsequent use;

[0050] (6) Mix the fine powders of (2), (3) and (4), add 100g polyethylene glycol anhydrous ethanol solution to make a ...

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PUM

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Abstract

The invention provides an effervescence tablet capable of treating penis erection dysfunction and preparation method thereof. The raw medicine of the effervescence tablet is 5 type phosphodiesterase (PDE5) selective inhibitor special for cyclic guanosine monophosphate (cGMP) wherein the active ingredient is invariant. The effervescence table is formed using effervescence material as disintegrating agent and generates a large amount of air bubbles in water. The effervescence tablet dissolves in shorter time with features of quick medicine effect, high bioavailability, convenient carryover, especially suitable for quick administration and patient incapable of swallowing solid preparation. The preparation method is simple and convenient.

Description

1. Technical field: [0001] The invention relates to an effervescent tablet and a preparation method thereof, in particular to an effervescent tablet for treating penile erectile dysfunction and a preparation method thereof. This effervescent tablet is a selective inhibitor of phosphodiesterase type 5 (PDE5) specific to cyclic guanosine monophosphate (cGMP). 2. Background technology: [0002] Effervescent tablets are a pharmaceutical dosage form, and according to the relevant laws and regulations on drug management in my country, changing the dosage form is managed as a new drug research. The original dosage form of this product is ordinary tablet, which has been included in the national quality standard for imported drugs. [0003] Erectile dysfunction (ED) is defined as the persistent inability to achieve or maintain an erection sufficient for sexual activity. ED can be divided into mild, moderate and severe according to its degree, and impotence belongs to severe ED. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K31/519A61K47/38A61P15/10
Inventor 李浪辉
Owner 李浪辉
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