Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ready-to-use traditional Chinese medicine ophthalmic gel

An ophthalmic and gel technology, applied in the field of ophthalmic instant gel preparations and Chinese medicine ophthalmic instant gel preparations, can solve the problems of increasing the action time of the drug, reducing the action time of the drug, lasting damage to the eye tissue, etc. Improved bioavailability, good sustained release properties, good fluidity

Inactive Publication Date: 2009-11-18
BEIJING HERUN INNOVATION PHARMA TECH DEV
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to tear dynamics, ophthalmic solutions have a very short residence time on the ocular surface, and the amount of drug absorbed is usually only a small part of the administered dose, even if the drug is on the surface of the eyeball, because of blinking and dilution of tears, the drug The effective concentration of the drug is reduced, and the action time of the drug is reduced, so the solution must be administered repeatedly to ensure the effective drug concentration, increase the action time of the drug, and achieve a higher drug absorption. This requires frequent eye drops, but frequent Drug administration can easily cause lasting damage to eye tissue, it is inconvenient to use, and it is difficult for patients to persist

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ready-to-use traditional Chinese medicine ophthalmic gel
  • Ready-to-use traditional Chinese medicine ophthalmic gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Prescription: pearl liquid 60ml, borneol 1.5g, gellan gum 18g

[0057] Preparation method: Take pearl powder, add 4 times the amount of water for injection, heat to boiling, keep warm for 24 hours, pour out the supernatant, filter, and concentrate properly to obtain pearl liquid (with a total protein content of not less than 1mg / ml) Add mannitol to 2700ml of water for injection, stir to dissolve, heat to boiling, add gellan gum, stir to dissolve, let cool to room temperature; take 1.5g of borneol, 1.8g of ethylparaben, add 9ml of ethanol to dissolve, Add 3g of polysorbate 80, add to the above solution under stirring, then add pearl liquid, add water for injection to 3000ml, pass through a microporous membrane, and aseptically package to obtain.

Embodiment 2

[0059] Prescription: pearl liquid 40ml, borneol 2g, gellan gum 10g

[0060] Preparation method: take pearl powder, add 6 times the amount of water for injection, heat to boiling, keep warm for 48 hours, pour out the supernatant, filter, and concentrate properly to obtain pearl liquid (with a total protein content of not less than 1mg / ml); Take gellan gum, boric acid, and borax, add them to 1900ml of water for injection, heat to boiling, stir to dissolve, cool to 80°C, add pearl liquid, cool down to 60°C while stirring, and dissolve 2g of borneol and 1g of ethylparaben In ethanol, add dropwise to the above solution while stirring, and add water for injection to 2000ml, stir for more than 30 minutes, pass through a microporous membrane, and pack aseptically to obtain the product.

Embodiment 3

[0062] Prescription: pearl liquid 10ml, borneol 0.5g, gellan gum 7g

[0063] Preparation method: take pearl powder, add 4 times the amount of 10% sulfuric acid solution, heat for 2 hours, filter, add calcium oxide to the filtrate to adjust to neutrality, filter, and concentrate properly to obtain pearl liquid (with a total protein content of not less than 1mg / ml); add gellan gum, boric acid, and borax to 950ml of water for injection, heat to boil, cool to 80°C, add pearl liquid, cool to 60°C while stirring, and add 0.5g of borneol and 0.5g of ethylparaben Dissolve in ethanol, add dropwise to the above solution while stirring, add water for injection to 1000ml, stir for more than 30 minutes, pass through a microporous membrane, and pack aseptically to obtain the product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a ready-to-use traditional Chinese medicine ophthalmic gel preparation, belonging to the field of traditional Chinese medicines. The active ingredient of the preparation is from pearls or pearl powder and borneol or natural borneol and the gel base material of the preparation mainly comprises gellan gum accounting for 0.4-0.7 percent of the total weight. The technical scheme overcomes the deficiencies that the prior pearl liquid or nacre digest ophthalmic preparation has low bioavailability, inconvenient use, short retention time, and the like and has the effects of reducing dose, prolonging the retention time in eyes, having convenient use and accurate dose, and the like.

Description

technical field [0001] The invention relates to an instant ophthalmic gel preparation of traditional Chinese medicine, especially an ophthalmic ophthalmic preparation with pearl liquid and borneol, or nacre powder hydrolyzate and natural borneol as active ingredients, and gellan gum as the main gel base material. The instant gel preparation belongs to the field of traditional Chinese medicine. Background technique [0002] Pearl Eye Drops, with pearl liquid and borneol as active ingredients, has the functions of clearing heat and purging fire, nourishing the liver and improving eyesight. It can be used for visual fatigue and chronic conjunctivitis caused by liver deficiency and fire hyperactivity. Long-term use can protect eyesight. Its drug specification has been published In the 17th volume of the standard issued by the Ministry of Traditional Chinese Medicine. Zhenshiming Eye Drops, with nacre powder hydrolyzed and natural borneol as active ingredients, has the functions...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K35/56A61K9/00A61K47/36A61K47/38A61P27/02A61K31/045A61K35/618
Inventor 朴美善王广录
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com