Ready-to-use traditional Chinese medicine ophthalmic gel

An ophthalmic and gel technology, applied in the field of ophthalmic instant gel preparations and Chinese medicine ophthalmic instant gel preparations, can solve the problems of increasing the action time of the drug, reducing the action time of the drug, lasting damage to the eye tissue, etc. Improved bioavailability, good sustained release properties, good fluidity

Inactive Publication Date: 2009-11-18
BEIJING HERUN INNOVATION PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to tear dynamics, ophthalmic solutions have a very short residence time on the ocular surface, and the amount of drug absorbed is usually only a small part of the administered dose, even if the drug is on the surface of the eyeball, because of blinking and dilution of tears, the drug The effective concentration of the drug is reduced, and the action time of t

Method used

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  • Ready-to-use traditional Chinese medicine ophthalmic gel
  • Ready-to-use traditional Chinese medicine ophthalmic gel

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0055] Example one:

[0056] Prescription: Pearl liquid 60ml, borneol 1.5g, gellan gum 18g

[0057] Preparation method: take pearl powder, add 4 times the amount of water for injection, heat to boiling, keep warm for 24 hours, pour out the supernatant, filter, and concentrate appropriately to obtain pearl liquid (containing total protein not less than 1mg / ml) ; Take mannitol into 2700ml water for injection and stir to dissolve, heat to boiling, add gellan gum, stir to dissolve, let cool to room temperature; take 1.5g borneol, 1.8g ethyl paraben, add 9ml ethanol to dissolve, Add 3g of polysorbate 80, add to the above solution under stirring, then add pearl liquid, add water for injection to 3000ml, pass through a microporous membrane, and sterilely divide to get it.

Example Embodiment

[0058] Embodiment two:

[0059] Prescription: Pearl Liquid 40ml Borneol 2g Gellan Gum 10g

[0060] Preparation method: take pearl powder, add 6 times the amount of water for injection, heat to boiling, keep for 48 hours, pour out the supernatant, filter, and concentrate appropriately to obtain pearl liquid (containing not less than 1mg / ml total protein); Take gellan gum, boric acid and borax into 1900ml water for injection, heat to boiling, stir to dissolve, cool to 80℃, add pearl liquid, cool to 60℃ while stirring, and dissolve 2g borneol and 1g ethyl paraben In ethanol, add dropwise to the above solution while stirring, and add water for injection to 2000ml, stir for more than 30 minutes, pass through a microporous membrane, and sterilely divide it to obtain.

Example Embodiment

[0061] Embodiment three:

[0062] Prescription: Pearl Liquid 10ml Borneol 0.5g Gellan Gum 7g

[0063] Production method: Take pearl powder, add 4 times the amount of 10% sulfuric acid solution, heat for 2 hours, filter, add calcium oxide to the filtrate to adjust to neutral, filter, and concentrate appropriately to obtain pearl liquid (containing total protein not less than 1mg / ml); add gellan gum, boric acid and borax to 950ml water for injection, heat and boil, cool to 80°C, add pearl liquid, cool to 60°C while stirring, add 0.5g borneol and 0.5g ethyl paraben Dissolve in ethanol, add dropwise to the above solution while stirring, and add water for injection to 1000ml, stir for more than 30 minutes, pass through a microporous membrane, and sterilely divide it to obtain.

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Abstract

The invention discloses a ready-to-use traditional Chinese medicine ophthalmic gel preparation, belonging to the field of traditional Chinese medicines. The active ingredient of the preparation is from pearls or pearl powder and borneol or natural borneol and the gel base material of the preparation mainly comprises gellan gum accounting for 0.4-0.7 percent of the total weight. The technical scheme overcomes the deficiencies that the prior pearl liquid or nacre digest ophthalmic preparation has low bioavailability, inconvenient use, short retention time, and the like and has the effects of reducing dose, prolonging the retention time in eyes, having convenient use and accurate dose, and the like.

Description

technical field [0001] The invention relates to an instant ophthalmic gel preparation of traditional Chinese medicine, especially an ophthalmic ophthalmic preparation with pearl liquid and borneol, or nacre powder hydrolyzate and natural borneol as active ingredients, and gellan gum as the main gel base material. The instant gel preparation belongs to the field of traditional Chinese medicine. Background technique [0002] Pearl Eye Drops, with pearl liquid and borneol as active ingredients, has the functions of clearing heat and purging fire, nourishing the liver and improving eyesight. It can be used for visual fatigue and chronic conjunctivitis caused by liver deficiency and fire hyperactivity. Long-term use can protect eyesight. Its drug specification has been published In the 17th volume of the standard issued by the Ministry of Traditional Chinese Medicine. Zhenshiming Eye Drops, with nacre powder hydrolyzed and natural borneol as active ingredients, has the functions...

Claims

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Application Information

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IPC IPC(8): A61K35/56A61K9/00A61K47/36A61K47/38A61P27/02A61K31/045A61K35/618
Inventor 朴美善王广录
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
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