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Ready-to-use zedoary turmeric oil ophthalmic gel

A technology of zedoary turmeric oil and ophthalmic use, which is applied in the field of traditional Chinese medicine, can solve the problems of reducing the action time of the drug, increasing the action time of the drug, lasting damage to the eye tissue, etc., and achieves good sustained release characteristics, improved bioavailability, and good fluidity.

Inactive Publication Date: 2009-11-18
BEIJING HERUN INNOVATION PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to tear dynamics, ophthalmic solutions have a very short residence time on the ocular surface, and the amount of drug absorbed is usually only a small part of the administered dose, even if the drug is on the surface of the eyeball, because of blinking and dilution of tears, the drug The effective concentration of the drug is reduced, and the action time of the drug is reduced, so the solution must be administered repeatedly to ensure the effective drug concentration, increase the action time of the drug, and achieve a higher drug absorption. This requires frequent eye drops, but frequent Drug administration can easily cause lasting damage to eye tissue, it is inconvenient to use, and it is difficult for patients to persist

Method used

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  • Ready-to-use zedoary turmeric oil ophthalmic gel
  • Ready-to-use zedoary turmeric oil ophthalmic gel
  • Ready-to-use zedoary turmeric oil ophthalmic gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Prescription: Curcuma 1000g, gellan gum 12g

[0064] Preparation method: take curcuma medicinal material, steam distillation to extract volatile oil, separate volatile oil, take 4g, add 15g polysorbate 80, grind well, and set aside; take 1600ml water for injection, add gellan gum, stir evenly, put in boiling water bath, stir To clarification, add 24g of boric acid, 1.2g of borax, and 1.2g of ethylparaben, heat to 70°C, stir until clarification, filter, add the above-mentioned zedoary oil while stirring, pass through a microporous membrane, add water for injection to 2000g, Autoclave at 120°C for 20 minutes, let cool, and pack aseptically.

Embodiment 2

[0066] Prescription: Curcuma 1000g, gellan gum 10g

[0067] Preparation method: take the curcuma medicinal material, steam distillation to extract volatile oil, separate volatile oil, take 2g, add 20g polysorbate 80, grind well, and set aside; take 1600ml water for injection, add gellan gum, stir evenly, put in boiling water bath, stir Until clarification, add triethanolamine and mannitol, then add 0.8g of benzalkonium chloride, stir until clarification, heat to 70°C, filter, add the above-mentioned zedoary oil while stirring, heat to 70°C, filter, add water for injection to 2000g, passed through a microporous membrane, and aseptically dispensed to get ready.

Embodiment 3

[0069] Prescription: Curcuma 300g, gellan gum 12g

[0070] Preparation method: take zedoary curcuma, steam distillation to extract volatile oil, separate volatile oil, add 24g polysorbate 80, grind well, and set aside; take 2400ml water for injection, add gellan gum, stir evenly, put in boiling water bath, stir until clear, Add citric acid and glycerin, then add 0.6g of methylparaben and 0.6g of propylparaben, stir until clear, heat to 70°C, filter, add the above-mentioned curcuma oil while stirring, heat to 70°C, filter After that, add water for injection to 3000g, autoclave at 120°C for 20 minutes, let cool, and aseptically subpackage to obtain.

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Abstract

The invention discloses a ready-to-use zedoary turmeric oil ophthalmic gel preparation, belonging to the field of traditional Chinese medicines. The active ingredient of the preparation is zedoary turmeric oil and the gel base material of the preparation mainly comprises gellan gum accounting for 0.4-0.7 percent of the total weight. The technical scheme overcomes the deficiencies that the prior zedoary turmeric oil ophthalmic preparation has low bioavailability, inconvenient use, short retention time, and the like and has the effects of reducing dose, prolonging the retention time in eyes, having convenient use and accurate dose, and the like.

Description

technical field [0001] The invention relates to an instant ophthalmic gel preparation of zedoary oil, in particular to an instant ophthalmic gel preparation with gellan gum as the main gel base material, belonging to the field of traditional Chinese medicine. Background technique [0002] The traditional Chinese medicine Zedoary is the rhizome of the Zingiberaceae Curcuma plant. It is a commonly used traditional Chinese medicine and is mainly produced in Guangxi, Sichuan, Zhejiang, Jiangxi and other places. Traditional Chinese medicine believes that curcuma has the effects of breaking blood stasis, promoting qi, eliminating stagnation and relieving pain. In recent years, it has also been found to have anti-cancer, anti-early pregnancy, anti-coagulation, anti-oxidation and liver protection activities. Curcuma contains two major components, namely volatile oil and curcuminoids. Curcumin substances have anti-inflammatory, anti-tumor, blood lipid-lowering, anti-oxidation, and ...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61K9/00A61K47/36A61K47/38A61K47/40A61P27/02
Inventor 朴美善王广录
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
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