Ready-to-use decumbent corydalis tuber ophthalmic gel

An ophthalmic and gel technology, which is applied in the field of ophthalmic ready-to-use gel preparations, can solve the problems of increasing drug action time, reducing drug action time, and lasting damage to eye tissues, so as to improve bioavailability and good sustained release characteristics , good fluidity effect

Inactive Publication Date: 2009-11-18
BEIJING HERUN INNOVATION PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to tear dynamics, ophthalmic solutions have a very short residence time on the ocular surface, and the amount of drug absorbed is usually only a small part of the administered dose, even if the drug is on the surface of the eyeball, because of blinking and dilution of tears, the drug The effective concentration of the drug is reduced, and the action time of the drug is reduced, so the solution must be administered repeatedly to ensure the effective drug concentration, increase the action time of the drug, and achieve a higher drug absorption. This requires frequent eye drops, but frequent Drug administration can easily cause lasting damage to eye tissue, it is inconvenient to use, and it is difficult for patients to persist

Method used

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  • Ready-to-use decumbent corydalis tuber ophthalmic gel
  • Ready-to-use decumbent corydalis tuber ophthalmic gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Prescription: summer free 200g gellan gum 12g

[0063] Preparation method: Take summer medicinal materials, grind them into coarse particles, reflux and extract with ethanol three times, each time for 1.5 hours, filter, combine the filtrate, recover ethanol under reduced pressure until there is no alcohol smell, filter, and set aside; take 1200ml of water for injection, add Gellan gum, stir evenly, put it in a boiling water bath, stir until clear, add 24g of boric acid, 1.2g of borax, 1.2g of ethylparaben, stir until clear, heat to 70°C, filter, add the above summer free while stirring The extract is passed through a microporous membrane, added with water for injection to 2000ml, sterilized under high pressure at 120°C for 20 minutes, allowed to cool, and then aseptically packaged to obtain the product.

Embodiment 2

[0065] Prescription: summer free 1500g gellan gum 25g sodium hyaluronate 5g

[0066] Preparation method: Take summer medicinal materials, grind them into coarse particles, reflux extract with 90% ethanol twice, each time for 2 hours, filter, combine the filtrate, recover ethanol under reduced pressure until there is no alcohol smell, filter, and set aside; take water for injection 3000ml, add gellan gum, stir evenly, put in a boiling water bath, stir until clear, add triethanolamine and mannitol, then add 2g of benzalkonium chloride, stir until clear, heat to 70°C, pass through a microporous membrane, stir Next, add the above-mentioned summer free extract, filter, add water for injection to 5kg, add sodium hyaluronate, fully swell, pass through a microporous membrane, and aseptically subpackage to obtain.

Embodiment 3

[0068] Prescription: summer without 1000g gellan gum 14g

[0069] Preparation method: Take summer medicinal materials, crush them into coarse particles, soak them in 90% ethanol for 12 hours, then carry out percolation extraction, collect 4 times the amount of percolation liquid, recover ethanol under reduced pressure until it has no alcohol smell, filter, and set aside; take injection Add 1000ml of water, add gellan gum, stir evenly, place in a boiling water bath, stir until clear, add citric acid and glycerin, then add 0.6g methylparaben and 0.6g propylparaben, stir until clear, heat Heat to 70°C, filter, add the above-mentioned summer free extract under stirring, heat to 70°C, filter, add water for injection to 2000g, autoclave at 120°C for 20 minutes, let cool, and aseptically dispense to obtain.

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Abstract

The invention discloses a ready-to-use decumbent corydalis tuber ophthalmic gel preparation, belonging to the field of traditional Chinese medicines. The active ingredient of the preparation is from decumbent corydalis tuber which is a traditional Chinese medicine and the gel base material of the preparation mainly comprises gellan gum accounting for 0.4-0.7 percent of the total weight. The technical scheme overcomes the deficiencies that the prior decumbent corydalis tuber ophthalmic preparation has low bioavailability, inconvenient use, short retention time, and the like and has the effects of reducing dose, prolonging the retention time in eyes, having convenient use and accurate dose, and the like.

Description

technical field [0001] The invention relates to an instant gel preparation for ophthalmic use in summer, in particular to an instant gel preparation for ophthalmology with gellan gum as the main gel base material, and belongs to the field of traditional Chinese medicine. Background technique [0002] In summer, the tubers of Corydalis genus Corydalis in the family Papaveraceae are widely distributed in East China, Henan, Hubei, and Hunan provinces. They have the functions of promoting blood circulation, dredging collaterals, and relieving pain. They are widely used in eye preparations. Summer Wuzhong mainly contains alkaloid components, such as protopine, tetrahydropalmatine, bikukuling, palmatine, corydine, jatrorrhizine, papaverine, etc. These components can be decocted for many times , ethanol extraction and other methods to extract and separate, clinical application proves that the total alkaloid components extracted by conventional extraction process have good curative ...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/00A61K47/36A61K47/38A61K47/40A61K47/34A61K47/32A61P27/10A61K125/00A61K47/10A61K47/26
Inventor 朴美善王广录
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
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