Method for evaluating lung infection medicine

Abstract

The invention provides a method for evaluating a lung infection medicine. In the method, an acinetobacter baumannii lung infection model is constructed by an ultrasonic atomization method, bacterium quantitative culture and pathological inspection are carried out, and comprehensive evaluation is carried out according to various indexes, such as general situations, pathological changes, lung bacterium number changes and the like, of rats at different infection time. The method for evaluating the medicine, which is provided by the invention, has the advantages of strong practicability, very high repeatability, reliability, applicability and controllability of the model, very small difference between model rats, good stability of the model, high similarity degree with a clinical pathogenic process, high model formation speed and the like, has the most pivotal advantage of simple operation of the model constructed by the method, can carry out batch operation simultaneously and provides a basis for researching on acinetobacter baumannii lung infection pathogenic mechanism and sieving treating medicines.

Description

technical field [0001] The invention belongs to drug evaluation, and relates to a drug evaluation method for pulmonary infection, in particular to a method for evaluating drug for Acinetobacter baumannii pulmonary infection. Background technique [0002] 1. The positive rate of sputum culture of Acinetobacter baumannii is high, and it is difficult to distinguish infection from colonization [0003] Bacterial infectious diseases are still common diseases in my country, and the proportion of infections caused by opportunistic pathogens is increasing, which seriously threatens human health. Acinetobacter baumannii is an important opportunistic pathogen in hospital infection. In recent years, Acinetobacter baumannii infection has been increasing day by day, and its drug resistance has been increasing, which has brought great difficulties to clinical treatment, and has attracted great attention from clinicians and microbiologists. In particular, during the military operations o...

AI Technical Summary

Problems solved by technology

[0005] At present, reports on the pathogenic mechanism of Acinetobacter baumannii are rare, and there is a very difficult problem that has been plaguing the clinic: it is difficult to distinguish whether Acinetobacter baumannii isolated from the respiratory tract is an infectious bacteria or a colonizing bacteria

[0006] 2. Current research on Acinetobacter baumannii lung infection lacks an ideal animal model

[0009] In view of the high incidence of clinical Acinetobacter baumannii lung infection and the lack of animal models for experimental research, at present, it is urgent to establish a stable and controllable, simple and practical, economical and convenient, good operability and high repeatability of Baumann's insufficiency Animal model of Acinetobacter lung infection to solve the problem of differential diagnosis between colonization and infection, and successfully carry out research on the pathogenic mechanism and treatment methods of imipenem-resistant Acinetobacter baumannii lung infection

Images