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External wrapping membrane and external wrapping membrane soft capsule thereof

A technology of outer coating and soft capsules, which is applied in capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., and can solve problems such as unreachable, delayed drug release, and unfavorable patients

Active Publication Date: 2009-12-23
BEIJING HANGYANG CAPSULE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But above-mentioned technology also has following shortcoming: (1) the soft capsule in this prior art is a kind of colonic drug release preparation, just lags behind for the drug release time of the disease at the small intestine place, thereby can not reach the purpose of administering drug in the small intestine , both are unfavorable for slowing down of patient's small intestine place disease, also cause burden to patient's normal organ simultaneously; Toxicity, which is undoubtedly harmful to the condition of frail patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A method for preparing outer-coated soft capsules, comprising the steps of:

[0028] (1) Weigh 51g ethyl phthalate cellulose, 29g hydroxymethyl propyl cellulose, 8.8g polyvinyl alcohol 3000, 0.8g sodium alginate, 9.8g oleic acid and 0.6g amaranth as solute, add An appropriate amount of water is used as a solvent, the mass ratio of the solvent to the solute is 0.8, the above solute and the solvent are fully mixed and emulsified at a temperature of 50° C. for 2 hours, and then left to stand at room temperature for later use;

[0029] (2) making soft capsule semi-finished products;

[0030] (3) Add the mixed solution described in step (1) into the film spraying machine, and at a temperature of 50°C, the above mixed solution is sprayed out from a nozzle with an aperture of 0.5mm by a pump and evenly attached to the film in step (2). ) on the outer surface of the soft capsule semi-finished product; in this step, the nozzle aperture is 0.5mm, so that the sprayed mixed soluti...

Embodiment 2

[0034] A method for preparing outer-coated soft capsules, comprising the steps of:

[0035] (1) making soft capsule semi-finished products;

[0036] (2) Weigh 42.1g ethyl phthalate cellulose, 34g hydroxymethylpropyl cellulose, 18.9g polyvinyl alcohol 3000, 0.4g sodium alginate, 4g oleic acid and 0.6g amaranth as solutes, add An appropriate amount of water is used as a solvent, the mass ratio of the solvent to the solute is 0.5, the above solute and the solvent are fully mixed and emulsified at a temperature of 40° C. for 3 hours, and then left to stand at room temperature for use;

[0037](3) Add the mixed solution described in step (2) into the film spraying machine, and at a temperature of 40°C, the above mixed solution is sprayed out from a nozzle with an aperture of 0.2 mm by a pump and evenly attached to the film in step (1). ) on the outer surface of the soft capsule semi-finished product; in this step, the nozzle aperture is 0.2mm, so that the sprayed mixed solution is...

Embodiment 3

[0041] A method for preparing outer-coated soft capsules, comprising the steps of:

[0042] (1) Weigh 25g of ethyl cellulose phthalate, 35g of hydroxymethylpropyl cellulose, 25g of polyvinyl alcohol 3000, 2g of sodium alginate, 12g of oleic acid and 1g of fruit green as a solute, and add an appropriate amount of water as Solvent, the mass ratio of the solvent to the solute is 1.1, the above-mentioned solute and solvent are fully mixed and emulsified at a temperature of 60°C for 0.5 hours, and then left to stand and cooled to room temperature for use;

[0043] (2) making soft capsule semi-finished products;

[0044] (3) Add the mixed solution described in step (1) into the spray film machine, and at a temperature of 60°C, the above mixed solution is sprayed out from a nozzle with an aperture of 0.7 mm by a pump and evenly attached to the film in step (2). ) on the outer surface of the soft capsule semi-finished product; in this step, the nozzle aperture is 0.7mm, so that the s...

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PUM

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Abstract

The invention relates to an external wrapping membrane and an external wrapping membrane soft capsule thereof. The external wrapping membrane comprises the following components: 25 to 70wt% of phthalic acid ethyl cellulose, 10 to 35wt% of hydroxymethyl propyl cellulose, 5 to 25wt% of polyvinyl alcohol 3000, 0.4 to 2wt% of sodium alginate, 3 to 12wt% of oleic acid and 0.1 to 5wt% of pigment. The invention provides the external wrapping membrane released in small intestines and obtained by a water system, the external wrapping membrane soft capsule and a preparation method thereof, and the soft capsule obtained by the preparation has higher safety.

Description

technical field [0001] The present invention relates to a capsule. Specifically, it is a soft capsule with an outer coating and the outer coating. Background technique [0002] At present, the commonly used material for preparing soft capsules is gelatin, and the common process is to mix gelatin, water, and glycerin, and add other auxiliary materials to make soft capsule rubber. Since the content of gelatin in the soft capsule rubber is the largest, the solubility of the soft capsule rubber in the human body is basically determined by the solubility of gelatin. Gelatin is a water-soluble substance, and its solubility in aqueous solution will increase with the increase of temperature. Within the range of human body temperature, the dissolution time of gelatin rubber is no more than 30 minutes. Therefore, most of the contents wrapped by the above-mentioned soft capsule rubber enter the human body and disintegrate and separate out in the stomach, but this will bring a series ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K9/48A61K47/36A61K47/32A61K47/12
Inventor 霍晋涛周洋程鹏
Owner BEIJING HANGYANG CAPSULE TECH
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