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Application of semen astragali complanati general flavone extract in the preparation of pulmonary fibrosis prevention drugs

A technology of pulmonary fibrosis and flavonoids from Radix japonica is applied in the application field of total flavonoids extract of Radix Radix officinalis in the preparation of medicines for preventing and treating pulmonary fibrosis, and achieves the effects of single component, exact curative effect and abundant medicinal materials.

Active Publication Date: 2012-05-02
JIANGSU SUDA INVESTMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Total flavonoids of Astragalus complanali (total flavonoids of Astragalus complanali) is an effective part extracted from shayuanzi, and there has been no literature report on the application of total flavonoids of Astragalus complanali in the prevention and treatment of pulmonary fibrosis

Method used

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  • Application of semen astragali complanati general flavone extract in the preparation of pulmonary fibrosis prevention drugs
  • Application of semen astragali complanati general flavone extract in the preparation of pulmonary fibrosis prevention drugs
  • Application of semen astragali complanati general flavone extract in the preparation of pulmonary fibrosis prevention drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1.1 Purpose of the experiment: To observe the effect of the total flavonoids extract of Fructus Shayuanzi on serum SOD and MDA in mice with pulmonary fibrosis induced by BLM

[0041] 1.2 Experimental materials

[0042] Experimental animals: 60 Kunming mice, both male and female, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. Experimental animal production license number: SCXK (Su) 2007-0007, experimental animal use license number: SYXK (Su) 2007-0035.

[0043] Experimental drug: total flavonoids extract of Fructus japonica (total flavonoid content ≥ 50%), batch number: 070623, brownish yellow, powdery solid, dissolved in distilled water, stored in a refrigerator at 4°C for later use, provided by the phytochemical department of our institute; bleomycin A5 (BLM A5), white freeze-dried powder, 15mg / bottle, produced by Nippon Kayaku Co., Ltd., product batch number: 640110, drug import registration certificate number: H200...

Embodiment 2

[0059] 2.1 Purpose of the experiment: To observe the effect of the total flavonoids extract of Fructus Shayuanzi on the ability of serum serum to inhibit the production of hydroxyl free radicals (·OH) in BLM-induced pulmonary fibrosis mice

[0060] 2.2 Experimental materials

[0061]Experimental animals: 60 Kunming mice, both male and female, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. Experimental animal production license number: SCXK (Su) 2007-0007, experimental animal use license number: SYXK (Su) 2007-0035.

[0062] Experimental drug: total flavonoids extract of Fructus japonica (total flavonoid content ≥ 50%), batch number: 070623, brownish yellow, powdery solid, dissolved in distilled water, stored in a refrigerator at 4°C for later use, provided by the phytochemical department of our institute; bleomycin A5 (BLM A5), white freeze-dried powder, 15mg / bottle, produced by Nippon Kayaku Co., Ltd., product batch number:...

Embodiment 3

[0078] 3.1 Purpose of the experiment: To observe the effect of the total flavonoids extract of Fructus Shayuanzi on the content of T-AOC and MDA in the lung tissue of mice with pulmonary fibrosis induced by BLM

[0079] 3.2 Experimental materials

[0080] Experimental animals: 60 Kunming mice, both male and female, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. Experimental animal production license number: SCXK (Su) 2007-0007, experimental animal use license number: SYXK (Su) 2007-0035.

[0081] Experimental drug: total flavonoids extract of Fructus japonica (total flavonoid content ≥ 50%), batch number: 070623, brownish yellow, powdery solid, dissolved in distilled water, stored in a refrigerator at 4°C for later use, provided by the phytochemical department of our institute; bleomycin A5 (BLM A5), white freeze-dried powder, 15mg / bottle, produced by Nippon Kayaku Co., Ltd., product batch number: 640110, drug import registr...

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Abstract

The present invention discloses the application of semen astragali complanati general flavone extractives in the preparation of pulmonary fibrosis prevention drugs, and a mouse pulmonary fibrosis model is copied by dripping bleomycin (BLM) in an air pipe. The semen astragali complanati general flavone extractives are firstly used as prevention drugs, the related biochemical indicator and pathological changes of pulmonary fibrosis animal pulmonary tissues and blood serum are observed, and the prevention function of the semen astragali complanati general flavone extractives for pulmonary fibrosis animal models and mechanism thereof are clarified, so test basis is provided for the semen astragali complanati general flavone extractives to prevent pulmonary fibrosis. The pulmonary fibrosis prevention drugs containing the semen astragali complanati general flavone extractives carrier of which the prevention has effective quantity can be combined with carriers which are acceptable on the pharmacy to prepare drugs.

Description

technical field [0001] The invention relates to the application of the effective part of a traditional Chinese medicine in the preparation of a medicine for preventing and treating pulmonary fibrosis, in particular to the application of total flavonoids extract of chrysanthemum seedlings in the preparation of a medicine for preventing and treating pulmonary fibrosis. Background technique [0002] Pulmonary (interstitial) fibrosis (Pulmonary fibrosis, PF), also known as interstitial lung disease (interstitiallung disease, ILD), is a kind of diffuse alveolitis and alveolar structural disorder of unknown cause, leading to alveolar and pulmonary interstitial fibrosis, A disease that can eventually cause respiratory failure. [0003] The pathological features of pulmonary fibrosis are mainly long-term pulmonary inflammation leading to persistent alveolar damage, proliferation of interstitial cells in the lung, massive deposition of extracellular matrix (ECM), and extensive lung p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481A61P11/00A61K131/00
Inventor 顾振纶蒋小岗贺海彪郭次仪周忠继
Owner JIANGSU SUDA INVESTMENT CO LTD
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