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Injection for treating piglet bacillary dysentery and preparation method thereof

An injection and bacterial technology, which is applied in the field of injection for treating piglet bacillary dysentery and its preparation, can solve the problems of unsatisfactory treatment effect and piglet gastrointestinal insufficiency, etc. Effect

Inactive Publication Date: 2010-06-30
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, antibiotics are commonly used in clinical treatment. Due to drug resistance and gastrointestinal insufficiency of piglets, the therapeutic effect is not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Accurately weigh 6g of Pulsatillae extract, 5g of Qinpi extract, 5g of Scutellaria baicalensis extract, 5g of Cortex Phellodendri extract, 10g of gentamicin sulfate, 200ml of ethanol, 50ml of benzyl alcohol, 1ml of Tween-80, and 0.5g of sodium bisulfite.

[0039] The preparation method of the injection is as follows:

[0040] (1) Mix the weighed extracts of Pulsatilla chinensis, bark extract and Phellodendron Phellodendri, add 100ml of distilled water, 200ml of ethanol, stir for 2 hours, and stand at 4°C overnight;

[0041] (2) filtering step (1) gained mixed solution, filtrate is concentrated under reduced pressure to half of original volume;

[0042] (3) Add Tween-80 and benzyl alcohol to the concentrated solution obtained in step (2), heat to 50°C, stir for 5 hours, and make it fully mixed until clear;

[0043] (4) Gentamicin sulfate is dissolved in distilled water, and added in the mixed solution of step (3);

[0044] (5) The Scutellaria baicalensis extract is add...

Embodiment 2

[0050] Accurately weigh 15g of Pulsatillae extract, 10g of Bark Bark extract, 15g of Scutellaria baicalensis extract, 10g of Cortex Phellodendri extract, 20g of gentamicin sulfate, 400ml of ethanol, 200ml of benzyl alcohol, 20ml of Tween-80, and 1.5g of sodium bisulfite.

[0051] The preparation method of the injection is as follows:

[0052] (1) Mix the weighed Pulsatilla chinensis extract, Bark Peel extract and Phellodendron Phellodendri extract, add 150ml of distilled water, 400ml of ethanol, stir for 4 hours, and stand overnight at 4°C;

[0053] (2) filtering step (1) gained mixed solution, filtrate is concentrated under reduced pressure to half of original volume;

[0054] (3) Add Tween-80 and benzyl alcohol to the concentrated solution obtained in step (2), heat to 60°C, stir for 3 hours, and make it fully mixed until clear;

[0055] (4) Gentamicin sulfate is dissolved in distilled water, and added in the mixed solution of step (3);

[0056] (5) Scutellaria baicalensis e...

Embodiment 3

[0062] Accurately weigh 10g of Pulsatillae extract, 7g of Qinpi extract, 12g of Scutellaria baicalensis extract, 6g of Cortex Phellodendron extract, 14g of gentamicin sulfate, 300ml of ethanol, 120ml of benzyl alcohol, 10ml of Tween-80, and 1g of sodium bisulfite.

[0063] The preparation method of the injection is as follows:

[0064] (1) Mix the weighed Pulsatilla chinensis extract, Bark Peel extract and Phellodendron Phellodendri extract, add 120ml of distilled water, 300ml of ethanol, stir for 3 hours, and stand overnight at 4°C;

[0065] (2) filtering step (1) gained mixed solution, filtrate is concentrated under reduced pressure to half of original volume;

[0066] (3) Add Tween-80 and benzyl alcohol to the concentrated solution obtained in step (2), heat to 65°C, stir for 2 hours, and make it fully mixed until clear;

[0067] (4) Gentamicin sulfate is dissolved in distilled water, and added in the mixed solution of step (3);

[0068] (5) Scutellaria baicalensis extrac...

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PUM

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Abstract

The invention discloses an injection for treating piglet bacillary dysentery and a preparation method thereof. 1000ml of injection comprises the following raw materials: 6-15g of Chinese anemone extractive, 5-10g of ash bark extractive, 5-15g of radix scutellariae extractive, 5-10g of amur corktree bark extractive and 10-20g of gentamycin sulfate. The invention mainly treats the piglet bacillary dysentery, has obvious curative effect particularly on piglet yellow-white dysentery, adopts an injection mode for drug administration, solves the difficulties of low drug bioavailability caused by incomplete piglet bioavailability function, and has the advantages of fast response, good curative effect, convenient use, no toxic or side effect, safety and reliability.

Description

technical field [0001] The invention relates to a medicine for animals, in particular to an injection for treating bacillary dysentery in piglets and a preparation method thereof. Background technique [0002] Piglet diarrhea caused by bacterial infection is very common, including piglet paratyphoid fever caused by Salmonella infection, piglet pullorum and yellow scour caused by E. Fever and high mortality are the main symptoms, and the onset is more common within 20 days of age. Piglet yellow and white scour is the collective name of piglet yellow scour and piglet pullorum. Its morbidity and mortality are high. It is one of the main diseases that cause low survival rate of piglets and affect the efficiency of pig farming. Piglet yellow scour, also known as early-onset colibacillosis, mainly occurs in piglets within a few hours after birth to 7 days old. The incidence of this disease is the highest in piglets born to first-born young sows, with acute onset and mortality Al...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61P31/04A61K31/7036
Inventor 吴红云李凤娟舒文辉
Owner ZHENGZHOU HOUYI PHARMA
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