Human 5,10-methenyltetrahydrofolate and its compound crystallization methods, crystals and application thereof

A technology of methylenetetrahydrofolate and leucovorin, which is applied in the field of crystallization, crystallization and application of human 5,10-methylenetetrahydrofolate synthase and its complexes, can solve strong cytotoxicity , the effect is not obvious enough, problems such as discovery
CN101781637BInactive Publication Date: 2012-09-05北京普赛资产管理有限责任公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
北京普赛资产管理有限责任公司
Publication Date
2012-09-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a crystal of humaniz 5,10-methenyltetrahydrofolate (MTHFS) and a crystallization method thereof, also relates to a crystal of a composite of the human 5,10-methenyltetrahydrofolate and ADP and a crystallization method thereof, a crystal of a composite of the human 5,10-methenyltetrahydrofolate and glutamic acid and a crystallization method thereof, a crystal of a composite of the human 5,10-methenyltetrahydrofolate and N5-imide phosphoric acid and a crystallization method thereof, and a crystal of a composite of the human 5,10-methenyltetrahydrofolate and a product, namely 10- methenyltetrahydrofolate and a crystallization method thereof, and also relates to important structure domains or peptide fragments in the crystals, and a method for designing and screening medicaments by using the structure domains or the peptide fragments.
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Description

technical field

[0001] The present invention relates to a crystal of human source 5,10-methinetetrahydrofolate synthase (MTHFS) and its crystallization method, and also relates to the synthesis of human source 5,10-methinetetrahydrofolate synthase and ADP Crystal of complex and method for crystallization thereof, Crystal of complex of human 5,10-methenetetrahydrofolate synthase and glutamic acid and method for crystallization thereof, human source 5,10-methinetetrahydrofolate Crystal of complex of folate synthase and N5-imine phosphate transition state and crystallization method thereof, crystal of complex of human source 5,10-methylenetetrahydrofolate synthase and product 10-formyltetrahydrofolate and its crystallization method Its crystallization method; it also relates to the structural domains or peptide fragments that play a key role in the enzymatic activity of human 5,10-methylenetetrahydrofolate synthase in these crystals; and the use of these important structural doma...

Claims

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