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Copper cluster two-photon absorbing material with living cell developing function and synthetic method thereof

A technology of two-photon absorption and cell imaging, which is applied in the direction of luminescent materials, copper organic compounds, chemical instruments and methods, etc., can solve the problems of not obtaining multi-branched monovalent copper clusters, large steric hindrance of pyridine ligands, etc. , to achieve the effect of high yield, low cost and low excitation energy

Inactive Publication Date: 2012-05-23
ANHUI UNIVERSITY
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, due to the large steric hindrance of pyridine ligands with D-π-A conjugated structures, no multi-branched monovalent copper clusters with large π-conjugated systems have been obtained so far.

Method used

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  • Copper cluster two-photon absorbing material with living cell developing function and synthetic method thereof
  • Copper cluster two-photon absorbing material with living cell developing function and synthetic method thereof
  • Copper cluster two-photon absorbing material with living cell developing function and synthetic method thereof

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Embodiment Construction

[0020] Now take R-CHO as 4-N, N-diethylaminobenzaldehyde is an example, and the non-limiting examples are described as follows:

[0021] 1. Preparation of pyridine ligands with D-π-A conjugated structure:

[0022] The synthetic route map is as follows:

[0023]

[0024] In the 50mL round bottom flask, add 11.3mL tert-butanol, 0.78g metal potassium, after the reaction is complete, add 1.77g 4-N, N-diethylaminobenzaldehyde (R 1 ), 0.975mL of 4-picoline, heated and stirred at 80°C for 2h, evaporated tert-butanol under reduced pressure, added 200mL of dichloromethane to the reaction solution, then poured the reaction solution into 200mL of ice-water mixture, stirred, and removed the lower layer of organic phase, the upper aqueous phase was extracted three times with 50mL dichloromethane respectively, the organic phases were combined, and poured into anhydrous Na 2 SO 4 , dried overnight, and distilled off dichloromethane to obtain a crude product, which was recrystallized fr...

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Abstract

The invention provides a copper cluster two-photon absorbing material with a living cell developing function, which is a univalent copper cluster with a multi-branched general chemical formula. The copper cluster two-photon absorbing material is prepared by the steps of: firstly, preparing a pyridine ligand from 4-methylpyridine and 4-N,N-2R-aminobenzaldehyde; and secondly, synthesizing a target product by using the pyridine ligand and cuprous iodide.

Description

1. Technical field [0001] The invention relates to a two-photon absorbing material and a preparation method thereof, in particular to a copper cluster compound two-photon absorbing material with low toxicity and a living tissue cell developing function and a synthesis method thereof. 2. Background technology [0002] In recent years, with the discovery of two-photon absorbing materials, two-photon fluorescence technology has made a major breakthrough in its application. Since the two-photon technology uses long-wavelength excitation (near-infrared), it has the characteristics of low excitation energy, long wavelength, strong penetration, and small photodamage. It has attractive application prospects in medical diagnosis and fluorescence microscopy imaging. In 2004, O'Halloran (J.Am.Chem.Soc., 2004, 126, 712-713) reported the use of Zn(II) ion-centered complex two-photon fluorescence microscopy in the detection of living tissue cells The application of this method has succes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F1/08C07F19/00C07F17/02C09K11/06
Inventor 田玉鹏汪徐春吴杰颖张胜义金葆康周虹屏杨家祥
Owner ANHUI UNIVERSITY
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