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Anti-infective medicinal composition for injection and preparation method thereof

A composition and anti-infection technology, applied in the field of medicine, can solve the problems of instability and poor solubility of cefmenoxime hydrochloride, and achieve the effects of improving stability and improving safety

Inactive Publication Date: 2010-09-01
深圳四环医药有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] In order to solve the poor solubility of cefmenoxime hydrochloride in the prior art and the problem of extreme instability in aqueous solution, the invention provides a kind of cefmenoxime hydrochloride with good solubility and high stability, Na 2 HPO 4 / NaH 2 PO 4 Pharmaceutical composition of buffer salt and PVPK-30 and its preparation

Method used

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  • Anti-infective medicinal composition for injection and preparation method thereof
  • Anti-infective medicinal composition for injection and preparation method thereof
  • Anti-infective medicinal composition for injection and preparation method thereof

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Embodiment Construction

[0055] The above-mentioned content of the present invention will be further described in detail through specific implementation in the form of examples below. However, it should not be construed that the scope of the above-mentioned subject matter of the present invention is limited to the following examples. All technologies realized based on the above contents of the present invention belong to the scope of the present invention.

[0056] The preparation of the composition aseptic powder injection of embodiment the present invention

[0057] Prescription 1

[0058] Cefmenoxime Hydrochloride 500g

[0059] Na 2 HPO 4 20g

[0060] NaH 2 PO 4 5g

[0061] PVPK-30 25g

[0062]

[0063] A total of 1000 sticks were prepared

[0064] Prescription 2

[0065] Cefmenoxime hydrochloride 1000g

[0066] Na 2 HPO 4 8g

[0067] NaH 2 PO 4 2g

[0068] PVPK30 10

[0069] ...

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Abstract

The invention belongs to the technical field of medicaments, and discloses an anti-infective medicinal composition of cefmenoxime hydrochloride, Na2HPO4 / NaH2PO4 buffer salt and PVPK-30 and a preparation method thereof. The weight ratio of the cefmenoxime hydrochloride to the Na2HPO4 / NaH2PO4 buffer salt to the PVPK-30 in the medicinal composition are 100 to 0.1-10 to 0.1-10; and the optimal weight ratio of the cefmenoxime hydrochloride to the Na2HPO4 / NaH2PO4 buffer salt to the PVPK-30 is 100 to 1 to 1. The medicinal composition solves the problems of poor dissolubility and stability of the cefmenoxime hydrochloride in the prior art, has stable characteristic, convenient storage and high dissolution velocity, and enhances the clinical medication safety.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, in particular to a kind of cefmenoxime hydrochloride, Na 2 HPO 4 / NaH 2 PO 4 Pharmaceutical composition of buffer salt and PVPK-30 and preparation method thereof. 2. Background technology [0002] Cefmenoxime hydrochloride (Cefmenoxime) is a semi-synthetic third-generation cephalosporin. The antimicrobial spectrum is similar to other third-generation cephalosporins, highly effective against Gram-negative bacteria, especially stable against β-lactamase produced by various negative bacteria, and has bactericidal effect. It is effective against Escherichia coli, Klebsiella, Serratia, Influenza, Enterobacter and Citrobacter. The antibacterial activity against Pseudomonas aeruginosa is stronger than cefoperazone and ceftizoxime, but the antibacterial effect against Streptococcus is not as good as the first and second generations. In 1983, cefmenoxime hydrochloride preparation was made in Jap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K47/02A61K47/22A61K9/14A61P31/04
Inventor 郭维城车冯升孟宪慧贾中新霍彩霞
Owner 深圳四环医药有限公司
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