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Hymecromone microemulsion medicament and preparation method thereof

A technology of hymecoumarin and microemulsion, which is applied in the direction of drug combination, anti-infective drug, emulsion delivery, etc., can solve the problems of unreachable therapeutic dose, limited clinical application, low solubility, etc., and achieve significant acaricidal effect, Enhanced drug efficacy and simple preparation process

Inactive Publication Date: 2012-02-22
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydroxymecoumarin is insoluble in water, and its solubility in organic solutions such as ethanol and propylene glycol is also low, and the therapeutic dose cannot be reached, thus limiting clinical application.
Currently, the widely used hymecoumarin preparations are hymecoumarin tablets and hymecoumarin capsules for the treatment of gallbladder disease, but no liquid preparations have been seen. As for the dosage form used for killing acarids, there has been no report

Method used

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  • Hymecromone microemulsion medicament and preparation method thereof
  • Hymecromone microemulsion medicament and preparation method thereof
  • Hymecromone microemulsion medicament and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Prepared a hymecoumarin microemulsion with a drug concentration of 0.1%.

[0048] Hydroxymecoumarin

0.1g

IPM

5.0g

Tween80

27.0g

PEG400

18.0g

Dimethyl sulfoxide

3.0g

distilled water

46.9g

[0049] Preparation:

[0050] (1) Weigh 0.1 g of hymecoumarin, 5.0 g of IPM, 27.0 g of Tween800, 18.0 g of PEG400, 3.0 g of dimethyl sulfoxide, and 46.9 g of distilled water, and set aside.

[0051] (2) Mix hymecoumarin with dimethyl sulfoxide to dissolve, add IPM, Tween80, PEG400 and mix until completely mixed; slowly add distilled water dropwise, while stirring continuously until a clear and transparent system, and then drop distilled water to a sufficient amount to obtain the hymecoumarin microemulsion drug with a drug concentration of 0.1% of the present invention.

Embodiment 2

[0052] Example 2 The hymecoumarin microemulsion with a drug concentration of 0.3% was prepared.

[0053] Hydroxymecoumarin

0.3g

Oleic acid

4.0g

EL-35

24.0g

ethanol

16.0g

Azone

5.0g

distilled water

50.7g

[0054] Preparation:

[0055] (1) Weigh 0.3 g of hymecoumarin, 4.0 g of oleic acid, 4.0 g of EL352, 16.0 g of ethanol, 5.0 g of azone, and 50.7 g of distilled water, and set aside.

[0056] (2) Mix and stir the mixture of hydroxymecoumarol, oleic acid, EL35, ethanol and azone until the hydroxymecoumarol is completely dissolved; slowly add distilled water dropwise, and keep stirring while dropping until a clear and transparent system, and then drop distilled water to a sufficient amount to obtain the hymecoumarin microemulsion drug with a drug concentration of 0.2% of the present invention.

Embodiment 3

[0057] Example 3 The hymecoumarin microemulsion with a drug concentration of 0.3% was prepared.

[0058] Hydroxymecoumarin

[0059] Preparation method: with embodiment 1.

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Abstract

The invention belongs to the field of veterinary medicaments, and relates to a hymecromone microemulsion medicament and a preparation method thereof. The hymecromone microemulsion medicament comprises the components in percentage by weight: 0.1 to 0.9 percent of hymecromone, 2.0 to 5.0 percent of oil, 20.0 to 30.0 percent of surfactant, 15.0 to 30.0 percent of cosurfactant, 3.0 to 5.0 percent of permeability promoter and 40.0 to 59.0 percent of distilled water. The medicament of the invention is clear and transparent and the particle diameter is between 10 and 100nm. The microemulsion has theadvantages of high stability, obvious acarid killing effect, improvement on the solubility of the hymecromone and the therapeutic effect of the medicament, simple preparation process, low toxicity and high safety.

Description

1. Technical field: [0001] The invention belongs to the field of veterinary medicine, and relates to a hymecoumarin microemulsion medicine and a preparation method thereof. 2. Background technology: [0002] Animal acariasis is an ectoparasitic disease characterized by severe skin itching, severe skin inflammation and contact transmission caused by carnivorous mites parasitizing on the surface or in the epidermis of animals. It is common in all parts of the world and occurs seasonally , can cause the digestion and absorption function of sick animals to decrease, the production performance and the quality of animal products to decline, and even cause a large number of animal deaths. Animal acariasis not only affects the healthy development of animal husbandry, but also threatens human health. At present, the prevention and control of mites is mainly based on drugs such as organochlorine and organophosphorus, but the long-term and large-scale use of such chemical acaricides ha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/37A61P33/14
Inventor 宋晓平吴明明付明哲
Owner NORTHWEST A & F UNIV
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