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Sodium selenite vitamin injection and preparation method thereof

A technology of sodium selenite and vitamins, which is applied in pharmaceutical formulations, active ingredients of sulfur/selenium/tellurium, medical preparations containing active ingredients, etc. It can solve the problems of long absorption time, affecting the production performance of dairy cows, and losses in cattle breeding, etc. problem, to achieve the effect of high bioavailability, prevention of cow reproduction, and convenient use

Inactive Publication Date: 2010-09-22
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the dairy cow lacks the above substances, it will cause a series of reproductive and growth diseases such as ovarian hypoplasia, estrus, infertility, stillbirth, calf white muscle disease, growth failure, postpartum retained placenta, and high incidence of metritis, which will greatly affect the health of dairy cows. Production performance, causing significant losses to the cattle industry
Generally, the methods of supplementing trace substances are oral and injection. Oral vitamins will be degraded in the rumen and the absorption time is long and the effect is not good. Therefore, injection should be the best way to supplement vitamins and selenium.
However, vitamins A, D, and E are fat-soluble substances, and sodium selenite, an inorganic substance for supplementing selenium, is a water-soluble substance. Now there are sodium selenite vitamin E injections and vitamin ADE injections on the market, and sodium selenite Making a compound water-soluble injection with vitamins A, D, and E requires research on pharmaceutical processes such as solubilization and emulsification, and there is no product on the market now

Method used

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  • Sodium selenite vitamin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Weigh 20 million units of vitamin A and vitamin D by weight 3 20 million units, vitamin E 5g, sodium selenite 1g, Tween 80 150g, Span 80 50g, polyoxyethylene castor oil (35) 50g, benzyl alcohol 10g, 2,6-di-tert-butyl p-cresol 2g ; vitamin A, vitamin D 3 , vitamin E, benzyl alcohol, and BHT were mixed, placed in a 60°C water bath to dissolve evenly, added part of water for injection, Span 80, Tween 80, polyoxyethylene castor oil (35) and stirred to dissolve, and sodium selenite Dissolve it with a small amount of water for injection and add it, stir well, add water for injection to the full amount, stir well to obtain a light yellow clear solution, filter, subpackage, and sterilize to obtain. Water for injection to 1000ml.

Embodiment 2

[0013] Weigh 80 million units of vitamin A and vitamin D by weight 3 10 million units, vitamin E10g, sodium selenite 10g, Tween 80 100g, Span 80 100g, polyoxyethylene castor oil (35) 20g, benzyl alcohol 50g, 2,6-di-tert-butyl-p-cresol 4g; vitamin A, vitamin D 3 , vitamin E, benzyl alcohol, and BHT were mixed, placed in a 60°C water bath to dissolve evenly, added part of water for injection, Span 80, Tween 80, polyoxyethylene castor oil (35) and stirred to dissolve, and sodium selenite Dissolve it with a small amount of water for injection and add it, stir well, add water for injection to the full amount, stir well to obtain a light yellow clear solution, filter, subpackage, and sterilize to obtain. Water for injection to 1000ml.

Embodiment 3

[0015] Weigh 10 million units of vitamin A and vitamin D by weight 3 80 million units, vitamin E 2g, sodium selenite 1g, Tween 80 50g, Span 80 50g, polyoxyethylene castor oil (35) 200g, benzyl alcohol 30g, 2,6-di-tert-butyl p-cresol 5g ; vitamin A, vitamin D 3 , vitamin E, benzyl alcohol, and BHT were mixed, placed in a 60°C water bath to dissolve evenly, added part of water for injection, Span 80, Tween 80, polyoxyethylene castor oil (35) and stirred to dissolve, and sodium selenite Dissolve it with a small amount of water for injection and add it, stir well, add water for injection to the full amount, stir well to obtain a light yellow clear solution, filter, subpackage, and sterilize to obtain. Water for injection to 1000ml.

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Abstract

The invention discloses sodium selenite vitamin injection and a preparation method thereof and belongs to the technology of veterinary medicaments. The vitamin injection is water-soluble injection which is prepared from active ingredients of vitamin A, vitamin D3, vitamin E and sodium selenite through a solubilizer Tween, span, polyoxyethylenated castor oil (35), a preservative 2, and 6-ditertiary butyl paracresol. The sodium selenite vitamin injection has the effects of improving the nutritional conditions of cows, enhancing the cow body physique, accelerating the oestrous period, improving the artificial fertilization and conception rate, preventing hysteritis and retained fetal membranes of the cows, promoting healthy development of calves, and preventing white muscle disease of the calves.

Description

technical field [0001] The invention belongs to veterinary medicine technology, and mainly relates to a sodium selenite vitamin injection and a preparation method thereof. Background technique [0002] Selenium and vitamins A, D, and E are special organic and inorganic elements necessary for dairy cows to maintain normal physiological activities, promote growth and development, and improve reproduction and production performance. If the dairy cow lacks the above substances, it will cause a series of reproductive and growth diseases such as ovarian hypoplasia, estrus, infertility, stillbirth, calf white muscle disease, growth failure, postpartum retained placenta, and high incidence of metritis, which will greatly affect the health of dairy cows. Production performance brings significant losses to the cattle industry. Generally, the methods of supplementing trace substances are oral administration and injection. Oral vitamins will be degraded in the rumen, and the absorption...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61K47/44A61K9/08A61P3/02A61K31/07A61K31/355A61K31/593
Inventor 岳奎忠张翔徐志辉
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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