Artemisia rupestris L pill and production method and application thereof

The technology of dripping pills and golden wormwood is applied to the dripping pills of golden wormwood and its production and application fields, which can solve the problems of low production cost and harm, and achieve the effects of simple equipment, stable and reliable process, and stable content of active ingredients.

Active Publication Date: 2012-07-04
XINJIANG QUANAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a Jinhao dripping pill and its production method and application, which overcomes the deficiencies of the prior art and solves the problems such as the harm of organic solvent residues to the human body caused by extraction with organic solvents such as petroleum ether and ethyl acetate. A new modern macroporous adsorption resin purification technology has been developed, and the obtained Jinhao dripping pills contain high artemisinic acid and total flavonoids, and the content of active ingredients in the obtained dropping pills is stable, and has obvious anti-inflammatory and analgesic effects, and can be used for rheumatism and rheumatoid The treatment of chronic arthritis, and the curative effect is remarkable, and the production method of the Jinhao dripping pill is easy to operate, and the production cost is low

Method used

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  • Artemisia rupestris L pill and production method and application thereof
  • Artemisia rupestris L pill and production method and application thereof
  • Artemisia rupestris L pill and production method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025]Example 1: Mix the same amount of Hypericum perforatum and Artemisia perforatum medicinal materials, grind them into coarse powder, add 8 times the amount of 60% ethanol to reflux and extract twice, each time for 1 hour, combine the extracts, filter the extracts, let cool, Centrifuge, concentrate the supernatant under reduced pressure to 0.20g crude drug per 1ml concentrated solution, pass through one or more macroporous adsorption resins in HPD100, HPD100A, HPD400 and HPD400A, the diameter-to-height ratio of the resin is 1:4, and the adsorption Speed ​​1.0BV / h, elution speed 1.0BV / h, first use 3BV water to elute at a flow rate of 3BV / h to wash away water-soluble impurities, then elute 4BV with 30% ethanol, elute 4BV with 70% ethanol, collect 30% and 70% ethanol eluent, ethanol is recovered under reduced pressure and concentrated to a clear paste with a relative density of 1.22 to 1.25 (60°C), and then dried in a vacuum oven (temperature 60°C) to obtain extract powder (10...

Embodiment 2

[0026] Example 2: Mix the same amount of Hypericum perforatum and Artemisia perforatum medicinal materials, grind them into coarse powder, add 10 times the amount of 70% ethanol to reflux and extract for 3 times, each time for 1.5 hours, combine the extracts, filter the extracts, let cool, Centrifuge, concentrate the supernatant under reduced pressure to contain 0.22g of crude drug per 1ml concentrated solution, pass one or more macroporous adsorption resins in HPD100, HPD100A, HPD400 and HPD400A, the resin diameter-to-height ratio is 1:7, and absorb Speed ​​2.0BV / h, elution speed 2.0BV / h, first use 4BV water to elute at a flow rate of 5BV / h to wash away water-soluble impurities, then elute 5BV with 30% ethanol, elute 5BV with 70% ethanol, collect 30% and 70% ethanol eluent, ethanol is recovered under reduced pressure and concentrated to a clear paste with a relative density of 1.22 to 1.25 (60°C), and then dried in a vacuum oven (temperature 60°C) to obtain extract powder (100...

Embodiment 3

[0027] Example 3: Mix the same amount of Hypericum perforatum and Artemisia perforatum medicinal materials, grind them into coarse powder, add 12 times the amount of 70% ethanol to reflux extraction for 3 times, each time for 2 hours, combine the extracts, filter the extracts, let cool, Centrifuge, concentrate the supernatant under reduced pressure to 0.25g of crude drug per 1ml concentrated solution, pass through one or more macroporous adsorption resins in HPD100, HPD100A, HPD400 and HPD400A, the diameter-to-height ratio of the resin is 1:10, and absorb Speed ​​3.0BV / h, elution speed 3.0BV / h, first use 5.0BV water to elute at a flow rate of 6.0BV / h to wash away water-soluble impurities, then elute 6.0BV with 30% ethanol, and elute with 70% ethanol 6.0BV, collect 30% and 70% ethanol eluent, recover ethanol under reduced pressure and concentrate to a clear paste with a relative density of 1.22 to 1.25 (60°C), and then dry it in a vacuum oven (temperature 60°C) to obtain Cream ...

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PUM

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Abstract

The invention relates to an artemisia rupestris L pill and a production method and application thereof, the method comprises the following steps: step I: CommonSt.John'swortHerb and artemisia rupestris L with equal quantity are mixed and are crushed into coarse powder, ethanol is added for backflow extraction, the extracting solution is filtered, cooled and centrifuged, and then supernate is concentrated; step II: the concentrated solution is purified by macroporous absorption resin, and effluent liquid is collected in different segments, the effluent liquid is concentrated and is dried to obtain extract powder for spare; step III: the dry extract powder is mixed with polyethylene glycol according to proportion, the mixture is melted by heating, and then pills are produced by dropping. The process in the invention is stable and reliable, the contents of effective ingredients in the pills are stable; the invention solves the problem that residual organic solvent caused by the extraction of organic solvents such as petroleum ether, ethyl acetate and the like is harm to human bodies. Compared with the prior art, the method in the invention is suitable industrial production; the artemisia rupestris L pill obtained in the invention has obvious anti-inflammatory analgesic activities which are proved by experiments in pharmacodynamics and is used for treatment of rheumatism and rheumatoid arthritis.

Description

technical field [0001] The present invention relates to the technical field of medicine, and relates to a Jinhao dripping pill and its production method and application, which relates to a pure Chinese medicine preparation, in particular to a Jinhao dropping pill for treating rheumatism and rheumatoid arthritis. The characteristics of traditional Chinese medicine treatment of rheumatism and rheumatoid arthritis, using macroporous resin technology and drop pill dosage form, to make a drop pill, which has the characteristics of fast curative effect and high cure rate. Background technique [0002] Rheumatism and rheumatoid arthritis are chronic autoimmune diseases mainly involving joint lesions. They are common and frequently-occurring diseases that seriously endanger human health. They are listed as clinical intractable diseases. cancer". Statistics show that there are about 400 million patients with rheumatism worldwide, which is the largest type of disease in the medical f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K9/20A61P29/00A61P19/02A61P19/04
Inventor 顾政一何承辉黄华孙艳刘宣麟
Owner XINJIANG QUANAN PHARMA
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