40results about How to "The content of active ingredients is stable" patented technology

The invention discloses a method for preparing nalmefene hydrochloride injection. The method comprises the steps of adding a certain amount of citric acid or citrate auxiliary material to the preparation when the nalmefene hydrochloride injection is prepared according to a common method, wherein the adding amount is 5-15g of citric acid or citrate added to each liter of injection; firstly, taking the prescribed auxiliary material in preparation, adding injection water to dissolve, adding active carbon to agitate and adsorb, filtering and removing impurities; adding the prescribed nalmefene hydrochloride under the protection of nitrogen, fully dissolving and sizing to an appointed constant volume by water, adjusting the pH value to 3.5-4.5; and finally conducting split charging, charging nitrogen, sealing and sterilizing after filtering by a filter. By adopting the method disclosed by the invention, the validity period of the nalmefene hydrochloride injection can be obviously prolonged; a specific citric acid pH value stabilizer is adopted; and the nalmefene hydrochloride injection has good stability, and stable sample appearance, pH value, effective ingredient content and related substances, and the like. Therefore, the safety of medication is ensured.

The invention relates to a pharmaceutical composition containing imipenem cilastatin sodium and preparation thereof, belongs to the field of medicine and aims at overcoming the technical shortcoming that an imipenem cilastatin sodium powder injection in the prior art causes large adverse effect on the centre. The invention provides a powder injection containing the imipenem cilastatin sodium through reasonable compatibility. The powder injection can effectively reduce the adverse effect on the centre of an imipenem cilastatin sodium compound preparation when being used for clinic antibacterial treatment, the stability of the re-dissolved powder injection can be remarkably improved, and therefore, the pharmaceutical composition is suitable for development of clinic treatment medicine.

The invention discloses a method for preparing 'Sanjin tablet' which comprises, (1) extracting Fructus Rosae Laevigatae, sheep opening, smilax China root, Lygodium japonicum, cat's-foot with water, (2) mixing the extract with pharmaceutically acceptable carrier, spray drying and granulating, (3) tabletting, (4) dressing.

The invention provides a preparation technology of radix salviae miltiorrhizae tablets. The preparation technology comprises the steps of cutting radix salviae miltiorrhizae medicinal materials in different batches into segments, detecting the extracts of radix salviae miltiorrhizae decoction pieces, and detecting the content of effective components, wherein (Chinese Pharmacopoeia) the radix salviae miltiorrhizae medicinal materials contain 3.0% or above of Salvianolic acid B, the total extracts are not less than 50.0%, according to different extracts and the content of the effective components, preparation is performed, so that the total extracts are 65%-75%, and the content of the Salvianolic acid B is 7%-9%; placing the decoction pieces prepared in the proportion in an extracting tank,adding 90% alcohol, performing extraction for 1.0 hour, and concentrating outlet liquid; adding water, and performing extraction for 1.5 hours; concentrating outlet liquid; merging the concentrated liquid, and then performing concentration once again; and performing spray drying, collecting powder, then performing granulation, and performing tabletting so as to obtain the radix salviae miltiorrhizae tablets. The preparation technology is suitable for industrial production.

The invention belongs to the field of medicinal preparations, and particularly relates to a honeysuckle throat clearing formula and a tablet preparation method thereof. The honeysuckle throat clearing tablets contain medicament extract and pharmaceutically acceptable diluting agent, lubricating agent and disintegrating agent. The honeysuckle throat clearing tablets prepared by the invention have a better treatment effect on acute pharyngitis.

The preparation method of regenerative plant of thunder god vine mainly utilizes the techniques of clonal variation, mutation, chromosome doubling, regeneration and hormoneless propagation, etc. Saidinvention not only can make mass propagation, and the propagation coefficient of every generation can be up to 5-6 times, and the triptolide alcohol content is 0.009-0.015%, and its total diterpene lactone content also is higher than that of commercial thunder god vine extract, and they can be retained stably.

The invention discloses a processing method of raw radix astragali decoction pieces and the raw radix astragali decoction pieces. The processing method comprises the following steps that (1), heat treatment is carried out on cleaned and selected radix astragali to obtain radix astragali subjected to heat treatment; and (2), the radix astragali subjected to heat treatment is sequentially moistened, sliced and dried to obtain the raw radix astragali decoction pieces. By means of the processing method, the content of calycosin-7-glucoside in the raw radix astragali decoction pieces can be increased, and the high astragaloside content can be kept.

The invention discloses a Chinese medicine composition for preventing and treating hyperuricemia and hyperlipemia and a preparation method thereof, and relates to medicine or health-care food for preventing and treating hyperuricemia and hyperlipemia.The Chinese medicine composition for preventing and treating hyperuricemia and hyperlipemia contains extract of a Chinese medicine formula, and according to the formula, the Chinese medicine composition is prepared from, by weight, 3-20 parts of coix seeds, 5-40 parts of glabrous greenbrier rhizome, 3-20 parts of plantain herbs, 1-9 parts of Chinese atractylode rhizome, 1-12 parts of the root of bidentate achyranthes, 1-9 parts of papaw and 1-9 parts of fructus cannabis.The Chinese medicine composition has the functions of clearing away dampness, eliminating water seepage and inducing diuresis for treating stranguria, can obviously regulate and treat the hyperuricemia and hyperlipemia and is free of toxic and side effects after being taken for a long time; the preparation technology is stable, and production feasibility is good.The medicine or health-care food for preventing and treating the hyperuricemia and hyperlipemia contains an effective dose of the Chinese medicine composition for preventing and treating the hyperuricemia and hyperlipemia.

The invention discloses a preparation method of herba centellae substitutional tea. The preparation method comprises the steps of (1) collecting: collecting centella leaves in two seasons of summer and autumn; (2) cleaning and selecting: removing foreign matters, branches or yellow leaves; (3) spreading for cooling: ventilating and spreading for cooling the centella at 26 to 30 DEG C; (4) de-enzyme: performing de-enzyme treatment on the centella leaves; (5) molding: putting raw materials after de-enzyme on rolling equipment, spreading for cooling firstly, then rolling to obtain strip decoction pieces; (6) drying: drying the rolled leaves under the condition that the temperature is 50 to 110 DEG C and the thickness is 1.0 to 3.0 cm, and the drying time is 1 to 2h; (7) controlling the humidity of the dried herba centellae substitutional tea to below 60 percent, and cooling the dried herba centellae substitutional tea to room temperature, and then performing subpackage to obtain a finished product. According to the preparation method of the herba centellae substitutional tea, all aspects such as the purity of materials, sensation of sense organs of the color, shape, smell and the like of the tea, the mobility of yield production, moisture and ash content, the content of active ingredients, long-term stability, brewing property of the decoction pieces, and the like are obviously superior to that of the existing technical scheme.

The invention discloses a taxol microcapsule as well as a preparation method and a detection analysis method of the taxol microcapsule. According the taxol microcapsule as well as the preparation method and the detection analysis method, gingko octenyl succinic acid modified starch is taken as a wall material, taxol is taken as a core material, the taxol microcapsule is prepared by adopting the spray drying technology, the preparation method is simple, the cost is low, and the preparation method is suitable for industrial production. According to the detection a method, taxol is taken as the reference substance, by detecting the embedding rate, the in-vitro dissolution rate and the release condition, the complete and advanced production system and the detection standard which is strong in specificity and is controllable are formed, thus the effective control over the quality of the medicine is improved, and the quality and curative effects of the taxol microcapsule are guaranteed.

The invention provides preparation and detection methods of a salvia miltiorrhiza shuxin capsule. The preparation method comprises the steps of soaking salvia miltiorrhiza serving as a raw material, and extracting by using ethanol to prepare clear paste; and adding auxiliary materials, and encapsulating to obtain the salvia miltiorrhiza shuxin capsule. The preparation method is simple, capable of completely retaining effective components and ensuring relatively-high effective component content and the quality of the salvia miltiorrhiza shuxin capsule, low in cost and also suitable for industrial production. The detection method comprises the steps of detecting effective components by taking a salvia miltiorrhiza reference medicine, a tanshinone IIA reference substance, a cryptotanshinone reference substance, a tanshinol reference substance, a salvianolic acid B reference substance and a protocatechualdehyde reference substance as references; and detecting content by taking salvianolic acid B as a reference substance. The adopted detection method for the components is strong in specificity, high in content detection accuracy, complete in effective component retention and capable of ensuring stable effective component content and the quality of the salvia miltiorrhiza shuxin capsule, so that all the components in salvia miltiorrhiza can take a synergistic effect, the curative effect is ensured, and the health of people is protected.

The invention discloses an immunity-enhancing cod-liver oil soft capsule, and the capsule comprises a content and a soft capsule skin in a weight ratio of (0.66-0.68): 1; the content is prepared from the following raw materials in parts by weight: 330 to 360 parts of cod liver oil, 0.35 to 0.38 part of antioxidant, 30 to 40 parts of calcium citrate, 16 to 20 parts of grape seed oil and 2.5 to 3.3 parts of emulsifier; the soft capsule shell is prepared from the following raw materials in parts by weight: 230 to 250 parts of gelatin, 23 to 25 parts of sodium alginate, 90 to 100 parts of glycerol and 230 to 250 parts of purified water. The invention also provides a preparation method of the immunity-enhancing cod-liver oil soft capsule. The pharmaceutical composition has good oxidation resistance and preparation stability.

The invention discloses traditional Chinese medicine health care solid Xiajiu and a preparation method thereof. The solid Xiajiu has the advantages that the traditional drinking mode of the solid Xiajiu can be still kept while traditional Chinese medicine components are introduced into the Xiajiu to give a medicinal health care value to the Xiajiu, a user can brew the solid Xiajiu containing the traditional Chinese medicine components and drink the Xiajiu in a sucking way instead of directly drinking Xiajiu finished liquor containing the traditional Chinese medicine components when drinking the Xiajiu, the Xiajiu and the method enhance enjoyment and cultural experience and feeling of consumers while giving medicinal liquor taste and medicinal health care value to the Xiajiu, and are beneficial to transmission of Xiajiu culture and promotion of Xiajiu products.