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A method for preparing levodopa buccal tablets using broad bean flowers and broad bean sprouts

The technology of broad bean sprouts and levodopa is applied in the directions of medical preparations, pharmaceutical formulas, plant raw materials and the like containing active ingredients, and can solve the problems of oral tablet mouthfeel, poor taste, no therapeutic effect, toxic and side effects, etc. It can improve human immunity, stabilize the content of active ingredients, and reduce side effects.

Active Publication Date: 2018-06-01
CROP RES INST OF FUJIAN ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problems with this type of product are that cat bean itself contains toxic alkaloids, and these alkaloids are likely to remain in the extract, which has certain toxic and side effects on the human body; It has no therapeutic effect by itself, and it may cause side effects if taken too much, and the taste and taste of the tablet are not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] First, prepare the levodopa powder:

[0033] 1) Under the condition of a temperature of 60°C, drying and pulverizing broad bean flowers to obtain broad bean flower powder;

[0034] 2) preparation molar concentration is the acetic acid aqueous solution of 0.1mol / L, adds acetic acid and is adjusted to pH and is 3.5;

[0035] 3) Add the above-mentioned broad bean flower powder into the aqueous acetic acid solution and mix evenly to obtain a mixed solution, and then ultrasonically extract the above-mentioned mixed solution under ultrasonic conditions for 30 minutes to obtain the broad bean flower extract; wherein, the mass ratio of the broad bean flower powder to the aqueous acetic acid solution is 1 :20.

[0036] 4) The above-mentioned broad bean flower extract is processed by membrane separation technology to obtain a levodopa concentrate, and then the levodopa concentrate is concentrated into an extract;

[0037] 5) Place the extract above in a freeze dryer to freeze-d...

Embodiment 2

[0047] First, prepare the levodopa powder:

[0048] 1) Under the condition of a temperature of 50°C, drying and pulverizing broad bean flowers to obtain broad bean flower powder;

[0049] 2) Prepare an aqueous acetic acid solution with a molar concentration of 0.1mol / L, and add acetic acid to adjust the pH to 3;

[0050] 3) Add the above-mentioned broad bean flower powder into the aqueous acetic acid solution and mix evenly to obtain a mixed solution, and then ultrasonically extract the above-mentioned mixed solution under ultrasonic conditions for 40 minutes to obtain the broad bean flower extract; wherein, the mass ratio of the broad bean flower powder to the aqueous acetic acid solution is 1 :twenty two.

[0051] 4) The above-mentioned broad bean flower extract is processed by membrane separation technology to obtain a levodopa concentrate, and then the levodopa concentrate is concentrated into an extract;

[0052] 5) Place the extract above in a freeze dryer to freeze-dry ...

Embodiment 3

[0062] First, prepare the levodopa powder:

[0063] 1) Under the condition of a temperature of 50°C, drying and pulverizing broad bean flowers to obtain broad bean flower powder;

[0064] 2) Prepare an aqueous acetic acid solution with a molar concentration of 0.1mol / L, and add acetic acid to adjust the pH to 4;

[0065] 3) Add the above-mentioned broad bean flower powder into the aqueous acetic acid solution and mix evenly to obtain a mixed solution, and then ultrasonically extract the above-mentioned mixed solution under ultrasonic conditions for 20 minutes to obtain the broad bean flower extract; wherein, the mass ratio of the broad bean flower powder to the aqueous acetic acid solution is 1 :18.

[0066] 4) The above-mentioned broad bean flower extract is processed by membrane separation technology to obtain a levodopa concentrate, and then the levodopa concentrate is concentrated into an extract;

[0067] 5) Place the extract above in a freeze dryer to freeze-dry to obt...

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PUM

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Abstract

The invention discloses a method for preparing levodopa buccal tablets by using broad bean flowers and broad bean sprouts, belonging to the field of biopharmaceuticals. First prepare levodopa powder and broad bean sprouts vegetable powder; then select a die, adjust the pressure and tablet weight; then mix the above-mentioned levodopa powder and broad bean sprouts vegetable powder in a certain proportion and place them in the die, and press them into tablets Obtain tablet; Put above-mentioned tablet again under ultraviolet ray and sterilize 15-20min, obtain levodopa buccal tablet. The levodopa buccal tablets prepared by the method of the present invention can not only achieve the effect of preventing and treating Parkinson's disease, reduce the side effects of chemical medicine levodopa buccal tablets, but also contain rich polysaccharides, vitamins and dietary fiber in broad bean sprouts vegetable powder etc., can improve human immunity, promote gastrointestinal peristalsis, help digestion, and prevent constipation. At the same time, the broad bean flower levodopa powder also contains polysaccharides, which improves the taste of the broad bean natural levodopa lozenges.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and in particular relates to a method for preparing levodopa buccal tablets by using broad bean flowers and broad bean sprouts. Background technique [0002] Levodopa is one of the precursors for the synthesis of norepinephrine and dopamine in humans and animals. It is a classic anti-parkinsonian drug and is clinically used for the treatment of Parkinson's disease. At present, levodopa drugs in medicine mainly use chemically synthesized levodopa components, which belong to the category of chemical drugs. [0003] Domestic manufacturers also extract levodopa from the cat bean plant and compress it into tablets by adding various chemical auxiliary materials such as binders. The problems with this type of product are that cat bean itself contains toxic alkaloids, and these alkaloids are likely to remain in the extract, which has certain toxic and side effects on the human body; It has no therapeu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61K31/198A61K9/20A61P25/16A61P3/04A61P1/14
Inventor 郑开斌李爱萍徐晓俞康玉凡郑金贵陈昱璇
Owner CROP RES INST OF FUJIAN ACAD OF AGRI SCI
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