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A kind of pharmaceutical composition containing zoledronic acid and its preparation

A technology of zoledronic acid and a composition, applied in the field of medicine, can solve the problems of increasing bone mineral density and bone weight coefficient, poor symptom control, increasing blood phosphorus and blood calcium content, etc., so as to reduce toxic side effects and improve drug use. Compliance and therapeutic effect, effect of stable content of active ingredients

Active Publication Date: 2016-03-30
CHINA NAT MEDICINES GUORUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to overcome the technical deficiencies in the prior art that the symptoms of osteoporosis after chemotherapy and radiotherapy of malignant tumors are not well controlled, the present invention provides a pharmaceutical composition for treating osteoporosis after chemotherapy and radiotherapy of malignant tumors. Ledronic acid and icariin are the active ingredients of the medicine, and the described medicine composition is used for the treatment of osteoporosis after chemotherapy and radiotherapy of malignant tumors, and the symptoms are well controlled, and the bone density and bone weight coefficient are increased, and the It has a significant synergistic effect in increasing the content of blood phosphorus and blood calcium, and is suitable for the treatment of osteoporosis caused by clinical tumor chemotherapy

Method used

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  • A kind of pharmaceutical composition containing zoledronic acid and its preparation
  • A kind of pharmaceutical composition containing zoledronic acid and its preparation
  • A kind of pharmaceutical composition containing zoledronic acid and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The freeze-dried powder injection of embodiment 1 pharmaceutical composition of the present invention

[0023] Prescription composition:

[0024]

[0025] Preparation process: Weigh zoledronic acid, icariin and excipients respectively according to the prescription amount, add the excipients into an appropriate amount of water for injection, stir to dissolve and adsorb with 0.1% activated carbon, add zoledronic acid, stir to dissolve and dissolve with citric acid Adjust the pH value to 6.0-7.0, sterilize and filter with 0.45 μm and 0.22 μm filters after constant volume, fill, half-tamp, and freeze-dry to obtain the freeze-dried powder injection of the composition of the present invention.

Embodiment 2

[0026] The freeze-dried powder injection of embodiment 2 pharmaceutical composition of the present invention

[0027] Prescription composition:

[0028]

[0029] The preparation method is the same as Example 1 of the present invention except that the prescription is different.

Embodiment 3

[0030] The freeze-dried powder injection of embodiment 3 pharmaceutical composition of the present invention

[0031] Prescription composition:

[0032]

[0033]

[0034] The preparation method is the same as Example 1 of the present invention except that the prescription is different.

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Abstract

The invention relates to a pharmaceutical composition containing zoledronic acid and a preparation thereof, belongs to the field of medicine and aims at overcoming the technical shortcoming that osteoporosis therapeutic drug is poor in symptom control effect after malignant tumor radiation and chemotherapy in the prior art and providing a pharmaceutical composition containing the zoledronic acid. The pharmaceutical composition is prepared into a freeze-dried powder injection, has good symptom control effect when being used for osteoporosis therapy after malignant tumor radiation and chemotherapy, has remarkable therapeutic effect on the aspects of bone mineral density improvement, bone weight coefficient increase and blood phosphor and calcium content rise and is suitable for treatment of osteoporosis caused by tumor chemotherapy.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing zoledronic acid and its preparation, in particular to a pharmaceutical composition containing zoledronic acid and icarigenin and its use for treating bone marrow after radiotherapy and chemotherapy for malignant tumors. The invention relates to a medicinal application of porosis, belonging to the field of medicine. Background technique [0002] Malignant tumor, often called cancer, is a common and frequently-occurring disease that seriously threatens human health. Currently, the three major methods for treating malignant tumors include chemotherapy (abbreviated as chemotherapy), surgery and radiotherapy. The application of traditional cytotoxic antineoplastic drugs or anticancer drugs to chemotherapy still occupies an extremely important position in the comprehensive treatment of tumors. Some malignant tumors such as choriocarcinoma and malignant lymphoma may be cured by chemothe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/675A61K9/19A61K47/12A61K47/10A61P19/10A61K31/352
Inventor 蒋敏陈梦柯姚磊徐静宋品王震宇王海翠
Owner CHINA NAT MEDICINES GUORUI PHARMA
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