Preparation and detection methods of salvia miltiorrhiza shuxin capsule

The technology of Danshen Shuxin capsule and detection method is applied in the directions of capsule delivery, medical preparations containing active ingredients, measuring devices, etc., and can solve the problems of cumbersome extraction process, danger of inflammability and explosion, and low standards.

Inactive Publication Date: 2015-04-22
SICHUAN FENGCHUN PHARMA
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

However, people found that Danshen Shuxin Capsules, which should have a good effect on treating such diseases, are not satisfactory and the effect is very unstable. The reason is that the original standard of Danshen Shuxin Capsules was established in the 1980s It was formulated and included in the seventh volume of the Ministry of Health's drug standard "Prescriptions of Traditional Chinese Medicine" in 1993. Due to the technological level at that time, the standard was very low. Among the detection methods, there was only one TLC identification of tanshinone IIA reference substance. To test one of the index components, there is no more comprehensive detection method, and there is no content detection measure. In addition, the preparation method of Danshen Shuxin Capsules also has a big problem. Limited by the level of understanding at the time, the main components of Danshen were not clarified. and the properties and functions of the corresponding ingredients, and there is no advanced equipment and facilities, so the extraction, concentration and drying process of Danshen is not well controlled, and the process conditions such as temperature, time, extraction solvent and pressure during the entire preparation process are not controlled. The method is to decoct with water first, remove the water-soluble ingredients, and lose the ingredients that have a good therapeutic effect
In addition, the temperature of the decoction process is high, which destroys a lot of alcohol-soluble components.
Secondly, the method of heating and refluxing was also used for the extraction of alcohol-soluble components, and the method of heating and refluxing was used for 3 times for as long as 5 hours. 10 times the amount of water for precipitation, and then drying, the drying process can not completely avoid the loss of active ingredients, so the resulting drug is not comprehensive active ingredients, the content of active ingredients is very low, the quality of the drug is very poor , can not achieve a better therapeutic effect, not only wasting resources, but also delaying the treatment of patients, so it is necessary and urgent to find a better extraction and preparation method
[0003

Method used

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  • Preparation and detection methods of salvia miltiorrhiza shuxin capsule
  • Preparation and detection methods of salvia miltiorrhiza shuxin capsule
  • Preparation and detection methods of salvia miltiorrhiza shuxin capsule

Examples

Experimental program
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Effect test

Embodiment 1

[0175] The preparation method of Danshen Shuxin Capsules:

[0176] Take 1000g of Salvia miltiorrhiza, crush it into a coarse powder, put it in a percolation tank, and press it tightly, take 4000ml of 40% ethanol, add it to the percolation tank until the liquid level of the ethanol is just 2 cm higher than the coarse powder of Salvia miltiorrhiza, soak at 10°C for 20 hours, then adopt the dynamic extraction method of percolation, release the leachate from the bottom of the diafiltration tank at a rate of 20ml per minute, collect it for later use, and while starting to release the leachate from the bottom of the diafiltration tank, remove the remaining ethanol from the diafiltration tank. The top of the tank is added at the same rate as the discharge rate at the bottom. Continue to collect leachate until the end of the addition, and filter all the leachate collected above until the leachate in the infiltration tank is exhausted. The filtrate is between 45 and 55 Recover ethanol ...

Embodiment 2

[0198]The preparation method of Danshen Shuxin Capsule

[0199] Take 1000g of Salvia miltiorrhiza, crush it into a coarse powder, put it in a percolation tank, press it tightly, take 5000ml of 70% ethanol, add it to the percolation tank, until the ethanol liquid level is just 10 cm higher than the salvia miltiorrhiza powder, soak at 30°C for 40 hour, then adopt the dynamic extraction method of percolation, release the leachate from the bottom of the diafiltration tank at a rate of 100ml per minute, collect it for later use, and while starting to release the leachate from the bottom of the diafiltration tank, remove the remaining ethanol from the diafiltration tank The top of the tank is added at the same rate as the discharge rate at the bottom. Continue to collect leachate until the end of the addition, and filter all the leachate collected above until the leachate in the infiltration tank is exhausted. The filtrate is between 45 and 55 Recover ethanol under reduced pressure ...

Embodiment 3

[0221] The preparation method of Danshen Shuxin Capsule

[0222] Take 1000g of Salvia miltiorrhiza, crush it into coarse powder, put it in a percolation tank, and press it tightly. Take 4500ml of 55% ethanol and add it to the percolation tank until the liquid level of ethanol is just 6 cm higher than the coarse powder of Salvia miltiorrhiza. Soak at 25°C for 30 hour, then adopt the dynamic extraction method of percolation, release the leachate from the bottom of the diafiltration tank at a rate of 60ml per minute, collect it for later use, and while starting to release the leachate from the bottom of the diafiltration tank, remove the remaining ethanol from the diafiltration tank The top of the tank is added at the same rate as the discharge rate at the bottom. Continue to collect leachate until the end of the addition, and filter all the leachate collected above until the leachate in the infiltration tank is exhausted. The filtrate is between 45 and 55 Recover ethanol under r...

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Abstract

The invention provides preparation and detection methods of a salvia miltiorrhiza shuxin capsule. The preparation method comprises the steps of soaking salvia miltiorrhiza serving as a raw material, and extracting by using ethanol to prepare clear paste; and adding auxiliary materials, and encapsulating to obtain the salvia miltiorrhiza shuxin capsule. The preparation method is simple, capable of completely retaining effective components and ensuring relatively-high effective component content and the quality of the salvia miltiorrhiza shuxin capsule, low in cost and also suitable for industrial production. The detection method comprises the steps of detecting effective components by taking a salvia miltiorrhiza reference medicine, a tanshinone IIA reference substance, a cryptotanshinone reference substance, a tanshinol reference substance, a salvianolic acid B reference substance and a protocatechualdehyde reference substance as references; and detecting content by taking salvianolic acid B as a reference substance. The adopted detection method for the components is strong in specificity, high in content detection accuracy, complete in effective component retention and capable of ensuring stable effective component content and the quality of the salvia miltiorrhiza shuxin capsule, so that all the components in salvia miltiorrhiza can take a synergistic effect, the curative effect is ensured, and the health of people is protected.

Description

technical field [0001] The invention relates to a method for preparing capsules from salvia miltiorrhiza as a raw material and a detection method for the capsules, in particular to a preparation method for Danshen Shuxin capsules and a detection method thereof. Background technique [0002] The original standard of Danshen Shuxin Capsules is recorded in the seventh volume of the Ministry of Health's drug standard "Chinese Medicine Prescriptions", the standard number is WS3-B-1294-93, and the prescription is a traditional Chinese medicine of Danshen medicinal material. After extracting the active ingredients, Danshen extract is obtained. Then add appropriate auxiliary materials to prepare pure Chinese medicine capsules, which have the functions of promoting blood circulation, removing blood stasis, calming the mind, and are clinically used to treat angina pectoris, chest tightness and palpitations caused by coronary heart disease. One of the commonly used medicines for angina...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/48A61P9/10A61P9/06G01N30/88
Inventor 钟茂团黎黎温国梁吴诗惠何德中古莉
Owner SICHUAN FENGCHUN PHARMA
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