Preparation method and detection method of salvia miltiorrhizagranules

A detection method and the technology of Danshen, which are applied in the preparation and detection of Danshen Granules, can solve the problems that the Granules have no good ingredients, the content detection method, the extraction process is cumbersome, and the product quality cannot be guaranteed.

Inactive Publication Date: 2015-04-01
九寨沟天然药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main active ingredients of Salvia miltiorrhiza, tanshinone Ⅱ A and salvianolic acid B, are not stable in properties, and are not resistant to high temperatures, and even lose more than 50% when heated at a low concentration for about 20 minutes at a temperature higher than 60 ° C.
[0004] Therefore, there are big problems in the preparation method of the original standard, and the prepared granule does not have a good composition and content detection method, so the quality of the product cannot be guaranteed, and the curative effect of the product cannot be guaranteed. Treatment is also a delay
[0005] For the extraction methods of the active ingredients of Salvia miltiorrhiza, there are great defects at present, such as the loss of active ingredients during the extraction process, the inability to make high-concentration extracts after extraction, the extraction process is too cumbersome, and the extraction process is flammable and explosive, etc.

Method used

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  • Preparation method and detection method of salvia miltiorrhizagranules
  • Preparation method and detection method of salvia miltiorrhizagranules
  • Preparation method and detection method of salvia miltiorrhizagranules

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Effect test

Embodiment 1

[0168] The preparation method of Danshen Granules:

[0169] Take 1000g of Salvia miltiorrhiza, crush it into a coarse powder, put it in a percolation tank, and press it tightly, take 4000ml of 40% ethanol, add it to the percolation tank until the liquid level of the ethanol is just 2 cm higher than the coarse powder of Salvia miltiorrhiza, soak at 10°C for 20 hour, then release the leachate from the bottom of the infiltration tank at a rate of 30ml per minute, collect it for later use, and release the remaining ethanol from the top of the infiltration tank at the same time as the bottom of the infiltration tank Add at the same speed, continue to collect the leachate until the leachate in the infiltration tank is exhausted, filter all the leachate collected above, and recover the ethanol from the filtrate under reduced pressure at 45-55°C to produce For clear ointment with a relative density of 1.25-1.30, add sucrose powder whose weight is 4-5 times that of the ointment, then a...

Embodiment 2

[0189] The preparation method of Danshen Granules:

[0190]Take 1000g of Salvia miltiorrhiza, crush it into a coarse powder, put it in a percolation tank, press it tightly, take 5000ml of 70% ethanol, add it to the percolation tank, until the ethanol liquid level is just 10 cm higher than the salvia miltiorrhiza powder, soak at 30°C for 40 hour, then release the leachate from the bottom of the infiltration tank at a speed of 100ml per minute, collect it for later use, and release the remaining ethanol from the top of the infiltration tank at the same time as the bottom of the infiltration tank Add at the same speed, continue to collect the leachate until the leachate in the infiltration tank is exhausted, filter all the leachate collected above, and recover the ethanol from the filtrate under reduced pressure at 45-55°C to produce For clear ointment with a relative density of 1.25-1.30, add sucrose powder whose weight is 4-5 times that of the ointment, then add 10g of citric a...

Embodiment 3

[0210] The preparation method of Danshen Granules:

[0211] Take 1000g of Salvia miltiorrhiza, crush it into coarse powder, put it in a percolation tank, and press it tightly. Take 4500ml of 55% ethanol and add it to the percolation tank until the liquid level of ethanol is just 6 cm higher than the coarse powder of Salvia miltiorrhiza. Soak at 25°C for 30 hour, then release the leachate from the bottom of the infiltration tank at a speed of 60ml per minute, collect it for later use, and release the remaining ethanol from the top of the infiltration tank at the same time as the bottom of the infiltration tank Add at the same speed, continue to collect the leachate until the leachate in the infiltration tank is exhausted, filter all the leachate collected above, and recover the ethanol from the filtrate under reduced pressure at 45-55°C to produce For clear ointment with a relative density of 1.25-1.30, add sucrose powder whose weight is 4-5 times that of the ointment, then add...

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Abstract

The invention provides a preparation method and a detection method of salvia miltiorrhizagranules. The preparation methodcomprises the following steps: salvia miltiorrhiza is taken as the raw material, soaked and extracted by ethanol to prepare clear paste, auxiliary materials are added, and the mixture is granulated to prepare a product. The method is simple, effective components are completely retained, the content is higher, the cost is low, the quality of the prepared salvia miltiorrhizagranules can be guaranteed, and the method is suitable for industrial production. For component detection of the detection method, salvia miltiorrhizareference crude herb, a tanshinone II A reference substance, acryptotanshinone reference substance, atanshinolreference substance, asalvianolic acid B reference substance and a protocatechualdehyde reference substance are taken as reference for effective component detection, salvianolic acid B is taken as the reference substance for content determination, the adopted component detection method has high specificity, the accuracy of content determination is high, the effective components are completely retained, the content is stable, and the quality of the prepared salvia miltiorrhizagranules is guaranteed, so that the synergistic effect of components of salvia miltiorrhiza is guaranteed, the efficacy of the salvia miltiorrhizagranulesis guaranteed, and the health of people is protected.

Description

technical field [0001] The invention relates to a method for preparing a granule from Danshen as a raw material and a detection method for the granule, in particular to a preparation method and a detection method for the Danshen granule. Background technique [0002] The original standard of Danshen Granules (Danshen Granules) is recorded in the sixth volume of the Ministry of Health's drug standard "Prescriptions of Traditional Chinese Medicine", and the standard number is WS3-B-1107-92. The function of blood stasis is mainly used clinically for the treatment of angina pectoris caused by coronary heart disease. With the improvement of people's living standards, cardiovascular diseases are on the rise, and there are more and more people with angina pectoris. However, people have found that Danshen Granules, which should have a good effect on treating such diseases, are not satisfactory and the effect is very unstable. The reason is that the original standard of Danshen Gran...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/16A61P9/10G01N30/02G01N30/36G01N30/90
CPCA61K36/537A61K9/1623A61K2236/333A61K2236/51G01N30/02G01N30/90G01N2030/027
Inventor 钟茂团黎黎邹波何德中常小平杨辉
Owner 九寨沟天然药业股份有限公司
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