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Taxol microcapsule as well as preparation method and detection analysis method thereof

A technology for paclitaxel and microcapsules, applied in the field of paclitaxel microcapsules and preparation thereof, can solve the problems of low solubility of paclitaxel, limited clinical application and the like, and achieve the effects of strong production process and specificity, guaranteed quality and curative effect, and low cost

Active Publication Date: 2017-04-19
JIANGSU AGRI ANIMAL HUSBANDRY VOCATIONAL COLLEGE
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Problems solved by technology

Due to the extremely low solubility of paclitaxel in water, it is clinically dissolved in polyoxyethylene castor oil and absolute ethanol and injected intravenously. After administration, there are severe allergic reactions and many toxic side effects, such as bone marrow suppression, neurotoxicity, cardiotoxicity, joint or Adverse reactions such as muscle pain, liver toxicity, and kidney toxicity limit its clinical application

Method used

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  • Taxol microcapsule as well as preparation method and detection analysis method thereof
  • Taxol microcapsule as well as preparation method and detection analysis method thereof
  • Taxol microcapsule as well as preparation method and detection analysis method thereof

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Embodiment Construction

[0025] Materials and reagents used: Ginkgo octenyl succinate starch ester, self-made in the laboratory; paclitaxel raw material, its purity > 99%, the production company is Nanjing Zelang Biotechnology Co., Ltd.; paclitaxel standard product, the production company is Shanghai A Latin Biochemical Technology Co., Ltd.; acetonitrile is chromatographically pure, methanol and absolute ethanol are analytically pure, and the production company is Shanghai Sinopharm Reagent Co., Ltd.; the water used in the experiment is distilled water.

[0026] Instruments and equipment used: AL204 analytical balance from Mettler-Toledo China Co., Ltd.; B-290 small spray dryer from Buchi Co., Ltd., Switzerland; experimental GYB high-pressure homogenizer from Shanghai Donghua Homogenizer Factory; High-performance liquid chromatograph from Waters Company in the United States; KQ3200 ultrasonic cleaning machine from Kunshan Ultrasound Instrument Co., Ltd.

[0027] Determination of paclitaxel content on ...

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Abstract

The invention discloses a taxol microcapsule as well as a preparation method and a detection analysis method of the taxol microcapsule. According the taxol microcapsule as well as the preparation method and the detection analysis method, gingko octenyl succinic acid modified starch is taken as a wall material, taxol is taken as a core material, the taxol microcapsule is prepared by adopting the spray drying technology, the preparation method is simple, the cost is low, and the preparation method is suitable for industrial production. According to the detection a method, taxol is taken as the reference substance, by detecting the embedding rate, the in-vitro dissolution rate and the release condition, the complete and advanced production system and the detection standard which is strong in specificity and is controllable are formed, thus the effective control over the quality of the medicine is improved, and the quality and curative effects of the taxol microcapsule are guaranteed.

Description

technical field [0001] The invention relates to a medicine prepared from paclitaxel, in particular to a paclitaxel microcapsule, a preparation method and a detection and analysis method thereof. Background technique [0002] Paclitaxel is a tetracyclic diterpenoid secondary metabolite extracted from Taxus plant tissue, which inhibits the proliferation and metastasis of various tumor cells and triggers significant apoptosis by promoting microtubule polymerization and stabilizing the polymerized microtubules. It is mainly used for the treatment of ovarian cancer, breast cancer, non-small cell lung cancer and colon cancer. Due to the extremely low solubility of paclitaxel in water, it is clinically dissolved in polyoxyethylene castor oil and absolute ethanol and injected intravenously. After administration, there are severe allergic reactions and many toxic side effects, such as bone marrow suppression, neurotoxicity, cardiotoxicity, joint or Adverse reactions such as muscle p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/337A61K47/36A61P35/00G01N13/00
CPCA61K9/5036A61K31/337G01N13/00
Inventor 张焕新郑义陆辉李永丁宁李登昌黄陈
Owner JIANGSU AGRI ANIMAL HUSBANDRY VOCATIONAL COLLEGE
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