Infrared spectrum detection method of ginseng and astragalus injection liquid

A technology of Shenqi injection and infrared spectroscopy, which is applied in the field of traditional Chinese medicine detection, can solve the problems of poor accuracy and reproducibility, long time required, and high cost, and achieve the effect of strong characteristics and small sampling volume

Inactive Publication Date: 2010-10-06
LI MIN PHARM FAB OF LIVZON PHARM GRP
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  • Abstract
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Problems solved by technology

Among the above six methods, the first three methods are simple and easy to implement, less costly and shorter in time, but the accuracy and reproducibility are poor
Thin-layer chromatography qualitative and semi-quantitative identification methods have high qualitative accuracy, but quantitative accuracy is average, time-consuming, and poor reproducibility
The accuracy and reproducibility of HPLC fingerprint qualitative and quantitative identification and HPLC-MS qualitative and quantitative identification are good, but the method is more complicated, takes a long time, consumes a lot, and is not suitable for rapid detection. In addition, the instrument Equipment requirements are relatively high

Method used

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  • Infrared spectrum detection method of ginseng and astragalus injection liquid
  • Infrared spectrum detection method of ginseng and astragalus injection liquid
  • Infrared spectrum detection method of ginseng and astragalus injection liquid

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Embodiment 1

[0028] Embodiment 1: a kind of infrared spectrum detection method of Shenqi injection, the method comprises the following steps: a, injection sample processing: adopt KBr adsorption method, get 0.07 milliliter of Shenqi injection and place in evaporating dish, add 80 milligrams The KBr spectrum is pure, evaporated to dryness on a water bath at 80 degrees Celsius, then scraped off, then added 65 mg of KBr, mixed and ground fully and evenly, and then pressed into tablets; Detect in the IR spectrum detector, measure the infrared spectrogram of the tablet sample; c, standard comparison: select 1 batch of Radix Codonopsis contrast medical materials, draw Radix Codonopsis infrared spectrum, find out 779, 818, 867, 1056 nearby specific substances according to Radix Codonopsis infrared spectrum Characteristic peaks; then select 10 batches of Shenqi injection control samples, draw infrared spectra, and use software to average the above spectra as standard control spectra. d, compare th...

Embodiment 2

[0029] Embodiment 2: a kind of infrared spectrum detection method of Shenqi injection, the method comprises the following steps: a, injection sample processing: adopt KBr adsorption method, get 0.15 milliliter of Shenqi injection and place in evaporating dish, add 100 milligrams The KBr spectrum is pure, evaporated to dryness on a water bath at 90 degrees Celsius, then scraped off, then added 75 mg of KBr, mixed and ground fully and evenly, and then pressed into tablets; Detect in the IR spectrum detector, measure the infrared spectrogram of the tablet sample; c, standard comparison: select 1 batch of Radix Codonopsis contrast medical materials, draw Radix Codonopsis infrared spectrum, find out 779, 818, 867, 1056 nearby specific substances according to Radix Codonopsis infrared spectrum Characteristic peaks; then select 10 batches of Shenqi injection control samples, draw infrared spectra, and use software to average the above spectra as standard control spectra. d, compare t...

Embodiment 3

[0030] Embodiment 3: a kind of infrared spectrum detection method of Shenqi injection, the method comprises the following steps: a, injection sample processing: adopt KBr adsorption method, get 0.20 milliliter of Shenqi injection and place in evaporating dish, add 120 milligrams The KBr spectrum is pure, evaporated to dryness on a water bath at 100 degrees Celsius, then scraped off, then added 80 mg of KBr, mixed and ground fully and evenly, and then pressed into tablets; Detect in the IR spectrum detector, measure the infrared spectrogram of the tablet sample; c, standard comparison: select 1 batch of Radix Codonopsis contrast medical materials, draw Radix Codonopsis infrared spectrum, find out 779, 818, 867, 1056 nearby specific substances according to Radix Codonopsis infrared spectrum Characteristic peaks; then select 10 batches of Shenqi injection control samples, draw infrared spectra, and use software to average the above spectra as standard control spectra. d, compare ...

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Abstract

The invention provides an infrared spectrum detection method of ginseng and astragalus injection liquid, which comprises the following steps: a. processing injection liquid samples; b. drawing maps; c. carrying out standard control; d. comparing the maps; and e. obtaining the conclusion: observing whether the ginseng and astragalus injection liquid to be detected conforms to the specification of the standard or not through the comparison and whether the maps conform to the standard maps obtained from the standard ginseng and astragalus injection liquid samples or not, and further obtaining the conclusion. The ginseng and astragalus injection liquid with the feature peak near 779, 818, 867 and 1056 and the similarity between 0.98 and 1.00 is selected as qualified products. The invention uses the macroscopical fingerprint performance of the infrared spectrum, the variation features of the infrared spectrogram is directly used on the quality control, or can be directly used on the quality control after digital processing, and the infrared spectrum technology is sufficiently utilized for fast monitoring the quality of the ginseng and astragalus injection liquid, including the stability, the ingredient variation, the adulteration, the impurities, unpredictable quality problems and the like of the ginseng and astragalus injection liquid.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine detection, and in particular relates to an infrared spectrum detection method of Shenqi injection. Background technique [0002] The main components of Shenqi injection are Codonopsis pilosula and Radix Astragali; it is prepared by the water extraction and alcohol precipitation method commonly used in traditional Chinese medicine preparations; it has the effect of nourishing qi and strengthening the body; it is used for the adjuvant treatment of lung cancer and gastric cancer with qi deficiency syndrome, and it can be used in combination with chemotherapy to improve the curative effect , Protect the blood, improve the immune function of patients with qi deficiency, improve the symptoms of qi deficiency and improve the quality of life. At present, the quality control methods of the injection include the following: visual observation of the color and properties of the injection,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/35G01N1/40G01N21/3577
Inventor 钟桂雄肖树雄周清刘学华
Owner LI MIN PHARM FAB OF LIVZON PHARM GRP
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