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Anti-septic shock medicine compound and application thereof

A composition and drug technology, applied in the directions of drug combinations, antibacterial drugs, active ingredients of heterocyclic compounds, etc., can solve the problems of large drug dosage, many side effects, adverse reactions of cardiovascular system and digestive system, etc., and achieve less toxic and side effects. , The anti-shock effect is enhanced and the effect is remarkable

Inactive Publication Date: 2010-10-13
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome that when the existing muscarinic receptor blockers are used to treat endotoxic shock, the dosage of the drug is large and the side effects are many, or the cholinesterase inhibitor will cause the accumulation of acetylcholine and cause cardiovascular disease. Systemic and digestive system adverse reactions, etc., providing a pharmaceutical composition with significant anti-infective shock, especially endotoxin shock, and less toxic and side effects and its application

Method used

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  • Anti-septic shock medicine compound and application thereof
  • Anti-septic shock medicine compound and application thereof
  • Anti-septic shock medicine compound and application thereof

Examples

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Embodiment 1-7

[0037] Table 1 shows the formulations of the pharmaceutical composition examples 1 to 7 of the present invention. According to the components listed in Table 1 and their proportions, the pharmaceutical compositions are simply mixed uniformly.

[0038] The formula of table 1 pharmaceutical composition of the present invention

[0039]

[0040]Note: The extraction method of the above-mentioned anisodamine plant extract can refer to the literature "Simultaneous analysis ofhyoscyamine, scopolamine, 6β-hydroxyhyoscyamine and apoatropine in Solanaceous hairyroots by reversed-phase high-performance liquid chromatography" (Journal of ChromatographyA, 2005, 1091(1- 2): 32-39); the extraction method of the scopolamine plant extract can refer to the literature "Analysis of tropane and related alkaloids" (Journal of Chromatography A, 2002, 978 (1-2): 1-35).

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Abstract

The invention discloses a medicine compound which contains muscarinic receptor antagonist and cholinesterase inhibitor. The medicine compound is used for resisting infection, particularly endotoxin shock, enhances the anti-shock effect, has significant effect, has small toxic and side effect, and overcomes the side effect that the current medicine normally causes. The invention also relates to application of the medicine compound in preparing anti-infectious, in particular to anti-endotoxin shock medicine.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, in particular to a pharmaceutical composition and its application. Background technique [0002] Septic shock can be seen in sepsis caused by various microorganisms (so it is also called septic shock), especially the infection of Gram-negative bacteria, and the shock caused by endotoxin (endotoxic shock). Endotoxin is a complex of lipopolysaccharide (Lipoply Saccharide) and trace protein (Protein) on the cell wall of Gram-negative bacteria. Endotoxic shock refers to a large amount of endotoxin acting on the immune system and blood coagulation system of the body, exceeding the clearance capacity of the body's own defense system, and producing a large amount of biologically active substances, such as tumor necrosis factor α, interleukin 1, histamine and kinin etc., leading to microcirculation disorder and coagulation dysfunction in the body, and a series of clinical symptoms appear. [...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61P9/00A61P31/04A61K31/46A61K31/27A61K31/407
Inventor 苏定冯刘冲孙利沈甫明
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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