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Process for producing heparin sodium

A production process, the technology of heparin sodium, which is applied in the field of drug preparation, can solve the problems of polluting the environment, wasting fat intestine residues, etc., and achieve the effects of reducing production costs, increasing added value, and simple resin regeneration

Inactive Publication Date: 2011-12-21
HANGZHOU LONGYANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the above-mentioned shortcomings in the prior art, the present invention finds another way, using the discarded pig intestine skin after removing the mucous membrane as raw material, aiming to provide a new production process of heparin sodium to solve the problem of a large amount of waste The environmental pollution and other problems of fat intestine dregs (mainly intestine skin) will further increase the added value of pig small intestine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The production technology of the heparin sodium of this implementation is as follows:

[0038] (1) Intestinal skin pretreatment process Production process:

[0039] Take the skin of the pig small intestine from which the mucous membrane has been removed, add water and crush it to make a paste, then add 1 times the weight of the intestine casing special salt for pickling treatment, and obtain the intestine skin slurry after pickling for one day,

[0040] (2) Adsorption process Production process:

[0041] Filter the intestinal skin slurry with a 60-mesh resin bag before entering the reaction tank, then dilute it with water to a salinity of about 4 degrees, and adjust the pH value to neutral with caustic soda, and then add 4kg of resin per 1000L intestinal skin slurry, Add Rohm and Haas FPA98 type resin, after stirring and adsorbing for 6 hours, collect the resin,

[0042] (3) Washing and elution process Production process:

[0043] The collected resin was washed repea...

Embodiment 2

[0052] The production technology of the heparin sodium of this implementation is as follows:

[0053] (1) Intestinal skin pretreatment process Production process:

[0054] Take the skin of the pig small intestine from which the mucous membrane has been removed, add water and crush it to make a paste, then add 1 times the weight of the intestine casing special salt for pickling treatment, and obtain the intestine skin slurry after pickling for one day,

[0055] (2) Adsorption process Production process:

[0056] Filter the intestinal skin slurry with an 80-mesh resin bag before entering the reaction tank, then dilute it with water to a salinity of about 5 degrees, and adjust the pH value to neutral with caustic soda, add 4.5kg of resin per 1000L intestinal skin slurry, Add Rohm and Haas FPA98 type resin, after stirring and adsorbing for 6 hours, collect the resin,

[0057] (3) Washing and elution process Production process:

[0058] The collected resin was washed repeatedly ...

Embodiment 3

[0067] The production technology of the heparin sodium of this implementation is as follows:

[0068] (1) Intestinal skin pretreatment process Production process:

[0069] Take the skin of the pig small intestine from which the mucous membrane has been removed, add water and crush it to make a paste, then add 1 times the weight of the intestine casing special salt for pickling treatment, and obtain the intestine skin slurry after pickling for one day,

[0070] (2) Adsorption process Production process:

[0071] Filter the intestinal skin slurry with a 60-mesh resin bag before entering the reaction tank, then dilute it with water to a salinity of about 5 degrees, and adjust the pH value to neutral with caustic soda, add 4kg of resin per 1000L intestinal skin slurry, add Rohm and Haas FPA98 type resin, after stirring and adsorbing for 8 hours, collect the resin,

[0072] (3) Washing and elution process Production process:

[0073] The collected resin was washed repeatedly wit...

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Abstract

The invention belongs to the field of preparation for medicaments, and in particular relates to a process for producing heparin sodium. In the process, the skin of small intestines of a pig from which mucosae is removed serves as a raw material, and the heparin sodium product is obtained by preprocessing, adsorbing, washing, eluting, precipitating and drying sequentially, wherein in the preprocessing step, the skin of the small intestines is crushed into paste, and then salt special for sausage casing is added into the paste for pickling; and in the adsorbing step, acrylic acid strongly basicanion exchange resin, namely rohm and haas FPA98 resin is adopted. The production process can effectively solve the problems of environmental pollution and the like caused by a large amount of waste intestine residue of the pig (the skin of the small intestines primarily), further increases the added value of the small intestines of the pig, and reduces the production cost; and the purity of the product is over 120 titers / mg.

Description

technical field [0001] The invention belongs to the field of medicine preparation, in particular to an environment-friendly production process of heparin sodium with high yield and high titer. Background technique [0002] Heparin sodium, Latin name Heparin Sodium, heparin sodium is mucopolysaccharide sulfate anticoagulant. Studies in recent years have proved that heparin sodium also has the effect of lowering blood lipids. At present, the methods of domestic production of heparin sodium are mainly salt hydrolysis and acid hydrolysis, such as the Chinese invention applications with publication numbers CN101735340A, CN101649008A, CN101519459A, etc., these two methods all adopt pig small intestinal mucosa as raw material, under alkaline conditions Through salt hydrolysis and enzymatic hydrolysis, after removing part of the protein, it is eluted by trimethylamine quaternary strong basic cation exchange resin adsorbent, and ethanol precipitation is added to the eluent. The prim...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/10
Inventor 花瑞华潘为群潘为中潘红苏吴鹏飞
Owner HANGZHOU LONGYANG BIOTECH
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