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Therapeutic compounds and their use in treating diseases and disorders

A compound and halogen technology, applied in the direction of carbohydrate active ingredients, metabolic diseases, allergic diseases, etc., can solve the problems that cannot be treated, cancer cannot be cured, and become resistant to standard treatment regimens, etc.

Inactive Publication Date: 2010-12-08
瑞科西有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite the vast number of treatments available for various cancers, the fact is that many cancers remain incurable, untreatable and / or become resistant to standard treatment options

Method used

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  • Therapeutic compounds and their use in treating diseases and disorders
  • Therapeutic compounds and their use in treating diseases and disorders
  • Therapeutic compounds and their use in treating diseases and disorders

Examples

Experimental program
Comparison scheme
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Embodiment

[0391] Chemical Synthesis and Purification of Example Compounds

[0392] All reactions were performed in flame-dried or oven-dried glassware under positive pressure of dry nitrogen or dry argon with magnetic stirring unless otherwise indicated. Chemicals were purchased from standard commercial vendors and used as received unless otherwise noted. Additionally, their preparation is readily and well known to those of ordinary skill in the art, or such preparation is mentioned or illustrated herein. The yield is not optimal. The names of the example compounds and intermediates were either obtained using the "ACD / Name" chemical naming software (version 8.08) from Advanced Chemistry Development, Inc. (Toronto, Ontario, Canada) or from MDL Information Systems (i.e. Isis, a Symyx Technologies, Inc. division (Santa Clara, CA) TM Generated by the "Autonom 2000" plug-in program of / Draw 2.5SP1 chemical drawing program.

[0393] Use analytical TLC plate (Silica Gel 60F254 or Merck EM-57...

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PUM

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Abstract

The invention provides novel therapeutic compounds, pharmaceutical compositions comprising these compounds, and methods for using these compounds and compositions to treat diseases and disorders, such as cancer.

Description

[0001] related priority application [0002] This application claims priority to US Provisional Application No. 60 / 988,069, filed November 14, 2007, which is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates to novel therapeutic compounds that inhibit heat shock protein 90 (Hsp90). The invention also relates to pharmaceutical compositions comprising these compounds, and methods of treating diseases and disorders that respond favorably to inhibition of Hsp90, such as cancer. Background technique [0004] Cancer is ubiquitous: Among U.S. citizens over age 70, the rate of invasive cancer is 38 percent for women and 46 percent for men. According to the American Cancer Society, there were approximately 1.4 million new cases of cancer in 2006 alone. Although the five-year survival rate for all cancers has increased from approximately 50% in the mid-1970s to 65% today, cancer remains the number one killer today. In fact, an ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/04A61K31/70C07D319/12
CPCC07D473/34A61P3/00A61P9/00A61P25/00A61P29/00A61P31/00A61P35/00A61P35/02A61P37/06A61P43/00
Inventor A·C·贝基S-H·金R·坦戈拉波利B·马克奥维兹R·特洛弗特M·B·安德森D·维特斯坦M·沈德露维琪
Owner 瑞科西有限公司