Transcatheter arterial chemoembolization embolism agent containing autophagy inhibitor

An autophagy inhibitor and hepatic artery technology, applied in the field of medicine, can solve problems such as unsatisfactory curative effect

Inactive Publication Date: 2011-01-26
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the existing TACE has its limitation

Method used

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  • Transcatheter arterial chemoembolization embolism agent containing autophagy inhibitor
  • Transcatheter arterial chemoembolization embolism agent containing autophagy inhibitor
  • Transcatheter arterial chemoembolization embolism agent containing autophagy inhibitor

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1. Preparation of hepatic arterial chemoembolization containing bafilomycin A1:

[0013] Dosage according to body weight is respectively cisplatin 2mg / kg, super-liquid lipiodol 0.2ml / kg, bafilomycin A1 0.6Ug / kg, with this proportioning, cisplatin, super-liquid lipiodol and bafilomycin A1 Floomycin A1 is evenly mixed to form hepatic arterial chemoembolization agent.

Embodiment 2

[0014] Embodiment 2. prepare the hepatic arterial chemoembolization agent containing chloroquine:

[0015] The dosage according to body weight is cisplatin 2mg / kg, super-liquid iodized oil 0.2ml / kg, and chloroquine 60mg / kg. In this proportion, cisplatin, super-liquid iodized oil and chloroquine are mixed evenly to form liver Arterial Chemoembolic Agents.

[0016] Animal experiment one. The embolic agent of the present invention that adopts is prepared by embodiment 1

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Abstract

The invention relates to the technical field of medicaments, and discloses a transcatheter arterial chemoembolization embolism agent containing an autophagy inhibitor for treating liver cancer. The embolism agent consists of a chemotherapy medicament, the autophagy inhibitor and iodized oil, wherein the chemotherapy medicament is cis-platinum; the iodized oil is liquid iodized oil; and the autophagy inhibitor is selected from bafilomycin A1 or chloroquine. The bafilomycin A1 or the chloroquine can be used as a sensitizer of the chemotherapy medicament, and can increase the sensitivity of liver cancer cells to the chemotherapy medicament in a hypoxic ischemic microenvironment after embolism and enhance the anti-cancer effect of the chemotherapy medicament. Animal experiments show that the embolism agent can achieve good curative effect for treating middle and late primary liver cancers, obviously increase the apoptosis rate and the necrosis rate of tumor cells and remarkably reduce tumors so as to improve the curative effect of transcatheter arterial chemoembolization. The invention provides the embolism agent with good curative effect and low injury for the transcatheter arterial chemoembolization.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a hepatic arterial chemoembolic agent containing an autophagy inhibitor for treating liver cancer. Background technique [0002] Transcatheter arterial chemotherapy (Transcatheter arterial chemotherapy, TACE) is the use of iodized oil and chemotherapeutic drugs to perfuse and embolize tumor supply arteries to form a microenvironment of ischemia and hypoxia and local chemotherapy. It is a safe and effective treatment for liver cancer. More than 90% of the blood supply of the tumor comes from the hepatic artery, while 75% of the blood of normal liver tissue comes from the portal vein, so arterial embolization will not have a great impact on the normal liver blood supply, but it blocks the main blood supply of the tumor, so , Most of the cancerous nodules are necrotic, but the liver function is not damaged or the damage is not serious. Moreover, chemotherapy drugs are selectively de...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61K31/4706A61K31/365A61K9/00A61K9/107A61P1/16A61P35/00
Inventor 卫立辛宋建瑞郭献灵赵雪刘燕赵秋东吴孟超
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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