Device for generating diffuse axonal injury to rodent

Abstract

The invention discloses a device for generating diffuse axonal injury to rodent, which comprises a base, a machine frame and a steam cylinder arranged on the machine frame, wherein an arm is arranged on one end of the steam cylinder; a rat head clamp and a gear are fixed on a central shaft and arranged on the base; a first metal rod is connected with the arm and the machine frame respectively, one end of a second metal rod is connected with the arm, and the other end of the second metal rod is connected with a sliding part; the central shaft is provided with the gear and connected with a rack fixed on the base in a meshed way, the central shaft is connected with sliding part through two bearings, and the sliding part is connected with a linear guide rail fixed on the base. The device can simultaneously generate a super-large angular acceleration and a linear acceleration at a moment to simulate the practical generation mechanism of the diffuse axonal injury. A rodent diffuse axonal injury model can be obtained by the device, and the injured axon is distributed in the brain in a diffused way and distributed at the junctions of different tissue structures, such as a cinereum matter junction, callosum, endocyst and brainstem.

Description

technical field [0001] The present invention relates to the fields of trauma neurosurgery, applied physics and applied mechanics. More specifically, it relates to a device for producing a model of diffuse axonal injury. Background technique [0002] The mortality rate of patients with diffuse axonal injury is extremely high, and most of the survivors have severe neurological dysfunction or even survive in a long-term vegetative state, which brings serious economic and mental burdens to families and society. At present, there is no significant progress in the clinical diagnosis and treatment of diffuse axonal injury, and the existing treatment measures still cannot significantly improve the prognosis of patients. A stable and reliable animal model is helpful to explore the mechanism of axonal injury and improve the clinical diagnosis and treatment of diffuse axonal injury. Correspondingly, there is an urgent need for an experimental setup that can replicate diffuse axonal i...

AI Technical Summary

Problems solved by technology

Current studies believe that the acceleration required to produce diffuse axonal injury increases with the decrease of the skull mass of the tested animal (the angular acceleration increases exponentially with the decrease of the skull mass), so the current model is difficult to use rodents such as rats Obtain a diffuse axonal injury model

[0011] 4. At present, it is believed that moderate angular acceleration and linear acceleration are the most common occurrences in clinical practice, and often lead to severe craniocerebral injury

However, the existing experimental setup cannot provide simultaneous angular acceleration and linear acceleration motion, nor can it be used to verify whether this wounding method can replicate the ideal diffuse axonal model

[0012] The experimental device that simultaneously produces instantaneous ultra-large angular acceleration and linear acceleration simulates the real mechanism of diffuse axonal injury. This device also reproduces the model of diffuse axonal injury in carious animals with clinical pathophysiological characteristics, and this experimental device Not yet reported

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