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Preparation method of Ditong rhinitis water

A technology for rhinitis and formula, applied in the field of traditional Chinese medicine, can solve problems such as difficulty in ensuring the effectiveness of finished preparations, loss of total solids and active ingredients, poor stability of finished products and the like

Active Publication Date: 2011-03-30
广西厚德大健康产业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large number of studies and practices have shown that the water extraction and alcohol precipitation method is easy to cause the loss of active ingredients, and there are many problems. The main problems are: ①The stability of the finished product is poor, especially the liquid preparation is prone to precipitation; ②The loss of total solids and active ingredients is serious, and it is difficult to To ensure the effectiveness of finished preparations, not only alcohol-insoluble substances such as polysaccharides and amino acids are removed, but also alcohol-soluble substances such as alkaloids, glycosides, and flavonoids are removed to varying degrees; High; ④ long production cycle

Method used

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  • Preparation method of Ditong rhinitis water
  • Preparation method of Ditong rhinitis water
  • Preparation method of Ditong rhinitis water

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Dandelion 6600g Scutellaria baicalensis 3300g Ephedra 2750g Xanthium 2750g

[0081] Magnolia 1375g Angelica dahurica 1375g Asarum 275g Shichangpu 3300g

[0082] The above raw materials, ephedra, angelica, cocklebur, asarum, shichangpu, magnolia, add 10 times the amount of water, distill with water steam, collect 11 liters of distillate, set aside, decoct the dregs, dandelion, and scutellaria baicalensis twice, the second Add 10 times the amount of water once, add 8 times the amount of water for the second time, each time for 1.5 hours, combine the decoction, filter through a 200-mesh filter cloth, concentrate the crude filtrate to a concentration of crude drug-medicine solution=1:5, and obtain the concentrated solution 108 Liter, spare.

Embodiment 2

[0084] Get 9.8 liters of the concentrated solution in Example 1, pass through the microfiltration of inorganic ceramic membrane with 0.5 μm pore size, the filtrate is concentrated to a thick paste with a relative density of 1.25 (60° C), add 1 liter of ephedra and other distillates in Example 1, and spit out Wen 80 80ml, glycerin 150ml, ethylparaben 15g (dissolved in 90g ethanol first), adjust the pH to 6.8, add water to 5 liters, filter, and pack to obtain.

Embodiment 3

[0086] Get 49 liters of the concentrated solution in Example 1, concentrate to the concentration of crude drug-medicine solution=1:1, obtain 9.9 liters of pre-filtrate liquid, pass 0.05

[0087] Inorganic ceramic membrane microfiltration of μm pore size, the filtrate is concentrated to the thick paste of relative density 1.15 (60 ℃), adds 5 liters of distillates such as ephedra among the embodiment 1, Tween 80 125ml, glycerol 250ml, ethylparaben 75g ( Dissolve it with 150g of ethanol), adjust the pH to 6.5, add water to 25 liters, filter, and put it into a drop bottle to obtain the Ditong Rhinitis Water Drops.

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Abstract

The invention discloses a drug preparation method of Ditong rhinitis water, which takes the following Chinese medicinal materials as raw materials: Mongolian dandelion herb, radix scutellariae, Chinese ephedra, cocklebur fruit, magnolia flower, dahurian angelica, asarum herb and the like. The preparation method comprises the following steps: distilling the Chinese ephedra, the cocklebur fruit, the magnolia flower, the dahurian angelica, the asarum herb and rhizoma acori tatarinowii with water vapor, and collecting distillate for use; decocting dregs, the Mongolian dandelion herb and the radix scutellariae with water; filtering, concentrating coarse filtrate or not, carrying out microfiltration or ultrafiltration on the concentrated filtrate, and then concentrating; and adding the distillate such as the Chinese ephedra and the like, Tween 80, glycerol and ethylparaben in proper amount, adjusting pH to 6-7, adding water in full quantity, filtering and sub-packaging to obtain the Ditong rhinitis water. Compared with a water-extraction and alcohol-precipitation method, the Ditong rhinitis water obtained by the preparation method has improved quality, better clarity, better stability and higher retention ratio of total solids and effective ingredients.

Description

field of invention [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a medicine preparation method of Ditong Biyan Water. Background technique [0002] The prescription of Ditong rhinitis water is recorded on page 199 of the fifth volume of the Ministry of Health's drug standard for traditional Chinese medicine preparations, and the standard code is WS3-B-1061-91. It is used for the treatment of cold and stuffy nose, nasal congestion (chronic rhinitis), rhinitis (allergic rhinitis), sinusitis (sinusitis) and other diseases. It has been clinically used for many years and has achieved satisfactory curative effect. In the ministerial standard, the prescription of this product is composed of 120g of dandelion, 60g of baicalin, 50g of ephedra, 50g of cocklebur, 25g of magnolia, 25g of angelica, 5g of asarum, and 60g of calamus. It is prepared according to the following process: Bawei, ephedra, angelica, cocklebur, ...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61K9/08A61K9/12A61P11/02
Inventor 莫少红阮碧芳梁霞梁尚焕廖九明陈晓军梁山丹梁月钊李品黄园廖厚知蒙华英吴伟
Owner 广西厚德大健康产业股份有限公司
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