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Active ingredient composition for treating alcoholic liver injury

A technology for alcoholic liver injury and active ingredients, applied in the direction of active ingredients of heterocyclic compounds, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of difficult control of dosage and safety, inconvenient use, etc. Accurate, safe and effective dosage of clinical medication, improved curative effect, and convenient use

Active Publication Date: 2012-09-19
王喜军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problems of inconvenient use, uncontrollable dosage and safety of existing traditional Chinese medicines for the treatment of liver damage and their compound decoctions, and provide a composition of active ingredients for the treatment of alcoholic liver damage

Method used

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  • Active ingredient composition for treating alcoholic liver injury
  • Active ingredient composition for treating alcoholic liver injury

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Effect test

specific Embodiment approach 1

[0010] Specific embodiment one: The active ingredient combination for the treatment of alcoholic liver injury in this embodiment consists of 16-20 parts of 6,7-dimethoxycoumarin, 7-11 parts of geniposide and 4 parts by mass. Composition of ~ 8 parts of rhein.

[0011] The main performance indicators of the active ingredient combination for treating alcoholic liver injury in this embodiment:

[0012] 1. Alanine aminotransferase (ALT) indicators:

[0013] ALT is mainly distributed in the liver cytoplasm. If liver cells die, alanine aminotransferase will increase. The increase is consistent with the degree of liver cell damage, so it is currently one of the most commonly used liver function indicators. One. The increase of ALT activity after ethanol administration indicates the destruction of liver cells and the enhancement of cell membrane permeability. It is suggested that the correlation coefficient between the normal physiological state of rats and the ALT index is disturbed afte...

specific Embodiment approach 2

[0028] Specific embodiment two: this embodiment is different from specific embodiment one in that the active ingredient combination for treating alcoholic liver injury consists of 16 parts of 6,7-dimethoxycoumarin and 7 parts of It is composed of geniposide and 4 parts of rhein. Others are the same as the first embodiment.

specific Embodiment approach 3

[0029] Specific embodiment three: This embodiment is different from specific embodiment one in that the active ingredient combination for the treatment of alcoholic liver injury consists of 20 parts of 6,7-dimethoxycoumarin and 11 parts of It is composed of geniposide and 8 parts of rhein. Others are the same as the first embodiment.

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Abstract

The invention discloses an active ingredient composition for treating alcoholic liver injury, and relates to an active ingredient composition for treating liver injury. The invention solves the problems that the conventional traditional Chinese medicines and compound decoction thereof for treating liver injury are inconvenient to use, and the dosage and safety are difficult to control. The active ingredient composition for treating the alcoholic liver injury consists of 6, 7-dimethoxybenzopyran-2-one, geniposide and parietic acid. The active ingredient composition for treating the alcoholic liver injury has the advantages that: the clinical medicinal dosage is accurate, safe and effective, the active ingredient composition is convenient to use, the treatment effect is improved, medicinal materials are saved, and toxic and side effects are reduced; and the 6,7-dimethoxybenzopyran-2-one, the geniposide and the parietic acid have liver-protecting and gut-benefiting components having the advantages of quick absorption (short time to peak), slow metabolism (longer half life of medicines), higher peak concentration and larger blood concentration area under a curve, so the 6, 7-dimethoxybenzopyran-2-one, the geniposide and the parietic acid can serve as preferred active ingredients. The active ingredient composition provides a basis for subsequently preparing finished pharmaceutical products in various formulations.

Description

Technical field [0001] The invention relates to an effective ingredient composition for treating liver injury. Background technique [0002] Although the traditional Chinese medicine and its compound decoction for the treatment of liver injury have certain curative effects, in clinical application, it is inconvenient to use, and the dosage and safety are difficult to control; this kind of medicine is not only time-consuming, and decoction is subject to many restrictions. For example, the decoction methods such as decoction time, decoction utensils, amount of water, heat, first decoction and second decoction are difficult to master. The decoction is completely based on experience, subjective and arbitrary, and lacks reliable quality inspection and monitoring methods. Many uncertain factors make it impossible to guarantee the clinical efficacy; and traditional Chinese medicines are generally only targeted at specific populations and specific diseases, and cannot be added or subtrac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/37A61K31/192A61P1/16
Inventor 王喜军孙晖孙文军吕海涛吴革林
Owner 王喜军
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