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Multi-functional wound dressing matrices and related methods

A wound dressing, multi-functional technology, applied in multi-functional wound dressing matrix and related fields, can solve the problems of slow healing speed, insufficient wound care, etc.

Inactive Publication Date: 2011-04-27
CELONOVA BIOSCIENCES INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Inadequate wound care can significantly slow healing, promote other secondary complications such as infection, and cause additional discomfort and pain

Method used

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  • Multi-functional wound dressing matrices and related methods
  • Multi-functional wound dressing matrices and related methods
  • Multi-functional wound dressing matrices and related methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0150] Prepared by dip-coating method thin matrix

[0151] In one embodiment, it can be prepared by dip coating method as follows substrate film. For the production of ultra-thin thin films, a programmable dip coating process can be used. Substrates that have been pre-cleaned and pre-treated with adhesion promoters can be treated with 0.5 to 50 mg / ml of Soak in the solution for a period of 0-5 minutes, and then they can be withdrawn from the solution at a speed of 50 μm / s up to 50 mm / min. After removal of the sample, an optional heat curing step at 40-80° C. for 10-30 minutes can be used to achieve residual solvent removal. The films so produced exhibit thicknesses of from about 0 to about 1.0 μm and from about 0-0.5 μm.

Embodiment 2

[0153] Prepared by spin-coating method thin matrix

[0154] In one embodiment, it can be prepared by spin-coating method as follows substrate film. In order to produce uniform ultra-thin on flat substrates For thin films, a spin-coating procedure can be used. Substrates that have been pre-cleaned and pre-treated with adhesion promoters can be placed in the center of a spin-coating device, with concentrations of 0.5 to 50 mg / ml in various solvents. 0.1 to 0.5 ml of the solution is spread on the substrate. After a dwell time of 1-10 seconds, a gradual ramp up from 10 rpm to 1000 rpm can be performed to achieve uniform spreading of the solution, followed by a midline ramp up to a target of 1000-2000 rpm at 1-10 second intervals to further thin the film. Finally, a final ramp up to 2000-4000 rpm can be performed after a dwell time of 5-120 seconds to achieve the desired film thickness. After removal of the sample, an optional heat curing step at 40-80° C. for 10-30 minut...

Embodiment 3

[0156] Prepared thick by spraying method matrix

[0157] In one embodiment, it can be prepared by spraying as follows substrate film. Pneumatic dual-feed coaxial nozzles with 0.5 mm orifice can be supplied with programmable syringe pumps in different solvent blends. solution. The concentration range of 0 to 20mg / ml, and can be supplied to the nozzle with a speed of 1-5ml / min. Depending on the viscosity of the solution, nebulization can be achieved with a pressure regime of 1.0-4.5 bar. The sample distance can be varied between 0-40 cm in the experiment. The resulting films exhibited a thickness of from about 1.0 to about 100 μm, depending on the length of spraying time used.

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Abstract

Various embodiments are directed to multi-functional wound-care dressing matrices that can protect and promote new tissue growth at a wound site. The multi-functional wound care matrix can incorporate poiyphosphazenes of formula I, as a component that can be configured into various forms, including as fibrous mats, porous membranes, nonporous films, particulate formulations, and equivalents, The multifunctional wound-care dressing matrix of the present disclosure exhibit high-performance properties conferred by poiyphosphazenes of formula L Exceptional biocompatible properties of poiyphosphazenes of formula I provide an ideal tissue-contacting surface for the multi-functional wound-care dressing matrix of interest.

Description

[0001] References to related applications [0002] This application claims the benefit under 35 U.S.C. §119(e) of US Provisional Patent Application No. 61 / 030,707, filed February 22, 2008, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure relates to various articles / devices incorporating and / or encapsulating polyphosphazene polymers that can improve the care and treatment of various types of wounds, and related methods. Background technique [0004] A variety of different articles and devices have been developed for managing the care and treatment of tissue injuries or trauma. Trauma is susceptible to a number of secondary effects that occur after initial tissue injury, including further mechanical trauma, pathogenic infiltration, infection, dehydration, excess fluid drainage, sepsis, inflammation, suppuration, scar tissue formation, healthy tissue hardening and / or tissue necrosis. Choosing the appropriate wound dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/22A61L15/42A61F13/02
CPCA61L15/26A61F13/02A61F13/00063A61F13/0206A61P17/02C08L85/02
Inventor 乌尔夫·弗里茨奥拉夫·弗里茨托马斯·A·戈迪
Owner CELONOVA BIOSCIENCES INC