Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Kit for detecting insulin allergen

A detection kit and insulin technology, applied in the field of detection kits, can solve problems such as time-consuming, cost-increased, and life-threatening to patients, and achieve the effects of simple operation, direct results, and low cost

Inactive Publication Date: 2011-05-04
HARBIN MEDICAL UNIVERSITY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no uniform standard and testing method for the detection of allergens in patients with insulin allergies at home and abroad. Generally, the allergic ingredients are only judged by constantly changing insulin dosage forms, which is time-consuming and expensive, and it is not conducive to blood sugar control and increases the physical and mental suffering of patients. and financial burden, individual patients even life-threatening

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] The preparation method of the insulin allergen detection kit of the present invention includes the following steps:

[0026] (1) Prepare recombinant human insulin, insulin aspart, insulin lispro, insulin glargine and porcine insulin dilutions according to the above concentration requirements,

[0027] (2) Prepare protamine, m-cresol, zinc chloride, paraben, benzoic acid, and low protamine dilutions according to the above concentration requirements,

[0028] (3) Prepare histamine phosphate diluent according to the above concentration requirements,

[0029] (4) Take recombinant human insulin, insulin aspart, insulin lispro, insulin glargine, porcine insulin, protamine, m-cresol, zinc chloride, paraben, benzoic acid, low protamine and histamine phosphate Solution 1.0ml, 0.9% saline 1ml as a test kit.

[0030] The insulin allergen test kit includes the following components:

[0031] Recombinant human insulin 1.0ml, the concentration is 5U / ml;

[0032] Insulin aspart 1.0ml, the concent...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a detection kit, in particular to a kit for detecting insulin allergen. The kit for detecting the insulin allergen comprises recombinant human insulin and human insulin analog (insulin aspart, insulin lispro and insulin glargine), swine insulin, and various insulin additives including protamine, m-cresol, zinc, p-hydroxybenzoate, benzoic acid and isophane. Histamine and a salt solution are respectively used as positive and negative control solutions. Hence, the kit disclosed by the invention has the advantages of simplicity of operation, accuracy in results and low cost, can be used for detecting the insulin allergen quickly, is suitable for clinic popularization and application, and provides a very valuable and practical detection method for clinic and scientific researches.

Description

Technical field [0001] The invention relates to a detection kit, in particular to an insulin allergen detection kit. Background technique [0002] With economic development and lifestyle changes, diabetes has become a global public health problem, and insulin is an indispensable drug for diabetes treatment. Due to the difference in amino acid composition of animal insulin and human insulin, it has antigenicity, leading to frequent occurrence of clinical allergy to insulin in diabetic patients. With the advent of genetically recombinant human insulin and human insulin analogues, allergic reactions were significantly reduced. However, with the widespread use of genetically recombinant human insulin and the like in recent years, allergic reactions are not uncommon. For the treatment of insulin allergy in diabetic patients, currently, there is no unified method in China, but the type and dosage of insulin are adjusted, and antihistamines, glucocorticoids, and skin test desensitizat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
Inventor 闫爽杨宝峰
Owner HARBIN MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com