Drug combination
A composition and drug technology, applied in the directions of drug combinations, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., can solve the problems of slow onset, short action time, adverse reactions, etc. The effect of quality improvement
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Embodiment 1
[0032] Clavulanic acid 0.5g
[0033] Sildenafil 50g
[0034] Starch 25g
[0035] Dextrin 35g
[0036] Low-substituted hydroxypropyl cellulose 5g
[0037] 60% ethanol appropriate amount
[0038] Magnesium Stearate 1g
[0039] Preparation process: Weigh clavulanic acid, clavulanic acid, sildenafil, starch, dextrin and low-substituted hydroxypropyl cellulose in the prescribed amount and mix them evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.
Embodiment 2
[0041] Clavulanate 100g
[0042] Sildenafil 25g
[0043] Microcrystalline Cellulose 180
[0044] Hydroxypropyl Cellulose 15g
[0045] 8% starch slurry appropriate amount
[0046] Magnesium Stearate 1.5g
[0047] Preparation process: Weigh clavulanic acid clavulanic acid, sildenafil, microcrystalline cellulose and hydroxypropyl cellulose and mix uniformly. Take another appropriate amount of 8% starch slurry solution, add it to the mixed powder, mix evenly to make a soft material, pass through a 16-mesh sieve to granulate, and dry below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.
Embodiment 3
[0049] Clavulanate 5g
[0050] Sildenafil 25g
[0051] Starch 25g
[0052] Dextrin 35g
[0053] Low-substituted hydroxypropyl cellulose 5g
[0054] 60% ethanol appropriate amount
[0055] Magnesium Stearate 1g
[0056] Preparation process: Weigh clavulanic acid, clavulanic acid, sildenafil, starch, dextrin and low-substituted hydroxypropyl cellulose in the prescribed amount and mix them evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.
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