Lipid preparation containing radix gentianae totalglycoside-phospholipid complexes and preparation method thereof

A technology of total glycoside phospholipids and complexes, which is applied in the field of lipid preparations containing gentioside phospholipid complexes and its preparation. Difficult to disperse and other issues, to achieve the effect of enhancing pharmacological effects and clinical efficacy, improving bioavailability, improving stability and transmembrane transport ability
CN102085238BInactive Publication Date: 2012-11-14FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2012-11-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the pharmacy field of traditional Chinese medicine and relates to a lipid preparation containing radix gentianae totalglycoside-phospholipid complexes and a preparation method thereof. The lipid preparation of the invention is formed by dissolving phospholipid complexes (which are formed by phospholipids and radix gentianae totalglycosides, which is the effective part of the traditional Chinese medicine) in one or a plurality of middle chain or long chain aliphatic acid glyceride(s) or in an oil phase with amphiphilic surfactants added thereto to prepare an oil solution composition; or dissolving the phospholipid complexes in a mixed solution which contains a certain proportion of surfactant, co-surfactant and oil phase to prepare a self-microemulsifying composition. The composition of the invention can substantially raise the capability of the radix gentianae totalglycoside-phospholipid complexes to penetrate biomembrane and enhance the biological availability of the radix gentianae totalglycosides.
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Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a lipid preparation containing gentioside phospholipid complex and a preparation method thereof Background technique

[0002] The prior art discloses that gentian glycosides are the effective parts of water-soluble split iridoid glycosides obtained by separating and purifying commonly used Chinese medicinal materials Radix Et Rhizoma Gentianae and Radix Gentianae Macrophyllae, and its active ingredients include Gentiopicroside, dangyaoside, dangyaopicroside, picrogentioside, picroside, etc. Among them, gentiopicroside has the highest content and the strongest activity. Studies have shown that gentiopicroside has significant anti-liver damage, anti-virus, and anti-inflammatory effects, and has important development value. However, because gentiopicroside has strong water solubility and poor transmembrane transport performance, it is difficult to penetrate the ga...

Claims

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