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Extract for preventing and treating angina pectoris and preparation method and application thereof

A technology of extracts and extracts, which is applied in the field of extraction of compound salvia miltiorrhiza preparations for cardiovascular drugs, can solve the problems of refining, the content of active ingredients needs to be improved, and lack of means for quality control, etc.

Inactive Publication Date: 2011-07-13
TIANJIN TASLY MORDEN TCM RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In the prior art, there is no step of monitoring and refining the active ingredients of the extract, so that the existing compound salvia miltiorrhiza preparations lack means for quality control, and the content of active ingredients still needs to be improved

Method used

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  • Extract for preventing and treating angina pectoris and preparation method and application thereof
  • Extract for preventing and treating angina pectoris and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Formula: Salvia 82.87%, Panax notoginseng 16.21%, Borneol 0.92%.

[0099] Preparation:

[0100] Step 1, salvia miltiorrhiza and Panax notoginseng are boiled and extracted twice with 8 times the weight of water, the first time is 2 hours, the second time is 1 hour, and the extracts are mixed.

[0101] In step 2, add ZTC1+1 natural clarifying agent 2% in turn to the extract, let stand for 8hr, and concentrate the supernatant under reduced pressure into extract,

[0102] Step 3, take the extract and borneol together as a pharmaceutical active ingredient, the substrate is a eutectic mixture of xylitol and starch, and the feeding ratio is: extract drug: substrate=1: 5.5, add borneol, liquid paraffin is a condensing agent, and the drug The temperature is 90°C, the mixing time is 1.5 hours, the temperature of the condensate is 1°C, the drop distance is 7cm, and the dropping rate is 35 drops per minute to prepare drop pills.

Embodiment 2

[0104] Formula: Salvia 20%, Panax notoginseng 79%, Borneol 1%.

[0105] Step 1, Salvia miltiorrhiza and Panax notoginseng are extracted with 2 times the weight of water, the extraction times are 2 times, each extraction is 1 hour, and the extracts are mixed.

[0106] In step 2, add ZTC1+1 natural clarifying agent 2% in turn to the extract, let stand for 12hr, and concentrate the supernatant into extract

[0107] Step 3, use the extract in step 2 and borneol together as the active ingredient of the medicine, the matrix is ​​a eutectic mixture of xylitol and starch, and the feeding ratio is: extract drug: matrix=1:3, add borneol, and liquid paraffin is a condensing agent , the temperature of the drug is 85°C, the time for mixing the material is 1 hour, the temperature of the condensate is -2°C, the drop distance is 5cm, and the dropping rate is 30 drops per minute.

Embodiment 3

[0109] Formula: Salvia 97%, Panax notoginseng 2%, Borneol 1.0%.

[0110] Step 1, Salvia miltiorrhiza and Panax notoginseng are extracted with 12 times the weight of water, the extraction times are 2 times, each extraction is 1 hour, and the extracts are mixed.

[0111] In step 2, add ZTC1+1 natural clarifying agent 2% in turn to the extract, let stand for 10hr, and concentrate the supernatant into extract,

[0112] Step 3, use the extract in step 2 and borneol together as the active pharmaceutical ingredient, the matrix is ​​a eutectic mixture of xylitol and starch, and the feeding ratio is: extract drug: matrix=1:7, add borneol, and liquid paraffin is a condensing agent , the temperature of the drug is 95 ° C, the time for mixing the material is 2 hours, the temperature of the condensate is 4 ° C, the drop distance is 10 cm, and the dropping rate is 45 drops per minute.

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Abstract

The invention relates to an extract for preventing and treating angina pectoris and a preparation method and application thereof. The preparation method provided by the invention comprises the following steps of: 1, extracting red sage root and notoginseng to obtain extracted solution; 2, flocculating the extracted solution to obtain extract; and 3, preparing a pharmaceutical preparation from the extract and borneol as the active components of the medicament.

Description

Technical field: [0001] The invention relates to a method for extracting a cardiovascular drug compound Salvia miltiorrhiza preparation, in particular to a method for purifying the extract. Background technique: [0002] Compound Danshen preparation is composed of Salvia miltiorrhiza, Panax notoginseng, borneol, etc. It has the effects of promoting blood circulation and removing blood stasis, regulating Qi and relieving pain. It has remarkable curative effect in the treatment of system diseases, digestive system diseases, kidney system diseases, etc. Therefore, it is more and more widely used. In recent years, it has been widely used in dermatology in addition to medical system diseases. [0003] The main aspects of the therapeutic effect of compound salvia preparations are: coronary heart disease, angina pectoris and microcirculation [0004] The nail fold microcirculation in patients with coronary heart disease shows obvious circulatory disturbance. The whole body micr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61P9/10A61K31/045
Inventor 刘岩陈红刘顺航徐波戚可人丛德刚赵国辉
Owner TIANJIN TASLY MORDEN TCM RESOURCES
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