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Pharmaceutical composition comprising cycloartenyl ferulate

A technology of pineapple enol ferulate and a composition, applied in the field of medicine, can solve the problems of low solubility, inability to solve the problems of pineapple enol ferulate being insoluble in water and the like

Active Publication Date: 2013-05-22
BEIJING CENTURY BIOCOM PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the research on the pure product of cycloartenol ferulate, the applicant found that its solubility in water is lower than that of oryzanol raw material, only about 1 / 3 of the solubility of oryzanol. The traditional technology used to solve the solubilization of oryzanol None of the schemes can solve the insoluble problem of cycloartenyl ferulic acid ester

Method used

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  • Pharmaceutical composition comprising cycloartenyl ferulate
  • Pharmaceutical composition comprising cycloartenyl ferulate
  • Pharmaceutical composition comprising cycloartenyl ferulate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 40g of s6, heat it to a molten state at 60°C, then add 8g of cycloartenyl ferulic acid ester to it, mix and stir for 15min, add the resulting molten liquid into 5L of water for injection and stir until it is completely dissolved. The pharmaceutical composition of the invention has a concentration of 1.6 mg / ml.

[0029] The resulting solution cleared completely on standing at room temperature for 24 hours.

Embodiment 2

[0031] Take 100g of S20, heat it to a molten state at 60°C, then add 10g of cycloartenyl ferulic acid ester to it, mix and stir for 30min, add the resulting molten liquid into 5L of water for injection and stir until it is completely dissolved. The inventive pharmaceutical composition has a concentration of 2 mg / ml.

[0032] The resulting solution cleared completely on standing at room temperature for 24 hours.

Embodiment 3

[0034]Take 200g s40, heat it to a molten state at 70°C, then add 5g cycloartenyl ferulic acid ester to it, mix and stir for 40min, add the obtained molten liquid into 4L water for injection and stir until it is completely dissolved, and obtain this product The pharmaceutical composition of the invention has a concentration of 1.25mg / ml.

[0035] The resulting solution cleared completely on standing at room temperature for 24 hours.

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Abstract

The invention discloses a pharmaceutical composition comprising cycloartenyl ferulate, which solves the problem that cycloartenyl ferulate is insoluble in water. The pharmaceutical composition disclosed by the invention comprises cycloartenyl ferulate and polyoxyl[40]stearate. A stable and water-soluble oryzanol pharmaceutical composition solution is obtained by adding cycloartenyl ferulate into molten polyoxyl[40]stearate. Further, the invention discloses a preparation method of the pharmaceutical composition solution and applications of the preparation.

Description

technical field [0001] The invention discloses a pharmaceutical composition of cycloartenol ferulate, which comprises cycloartenol ferulate and polyoxyl stearate, and belongs to the field of medicine. Background technique [0002] Oryzanol is a natural mixture composed of cycloartenol ferulic acid esters and sterol ferulic acid esters. The main two components are cycloartenol ferulic acid esters and 24 - Methyl cycloartenol ferulate, the content of the two in unpurified oryzanol is about 70%, and it is the main active ingredient in oryzanol. Long-term studies have found that oryzanol has a variety of pharmacological activities, such as lowering blood lipids, lowering cholesterol absorption, preventing lipid oxidation, preventing cardiovascular diseases, alleviating various physical obstacles and autonomic nervous disorders in women after menopause, and improving diencephalon function out of tune. [0003] In the existing technical schemes, oryzanol is usually added to surf...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61K47/32A61K47/24A61K47/10A61K47/16A61P3/06A61P9/00A61P15/12A61P25/00
Inventor 郝守祝
Owner BEIJING CENTURY BIOCOM PHARMA TECH
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