Shiqi exogenous Chinese medicinal buccal tablets

Abstract

The invention relates to Chinese medicinal tablets for treating and preventing influenza, which are prepared from the following Chinese medicinal raw materials and a pharmaceutically-acceptable carrier: 245 to 980 grams of holly root, 245 to 980 grams of berchemia lineate, 245 to 980 grams of syzygium jambos, 98 to 392 grams of simple glorybower root and 245 to 980 grams of pandanus tectorius parkins.

Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine buccal tablet for treating and preventing influenza and a preparation method thereof. Background technique

[0002] Both colds and influenza are caused by viral infections. Since the virus is airborne, it is the nose that bears the brunt. The virus first infects the nasal mucosa and then multiplies continuously, causing inflammation of the nasal mucosa and symptoms such as sneezing, runny nose, and nasal congestion. A common cold refers to a nasal cold, which generally affects the human body only on the respiratory system. All symptoms are related to the nose, such as runny nose, stuffy nose and sore throat, cough, and even fever. It usually heals in a few days. Influenza is caused by influenza virus. Influenza symptoms affect the whole body, including fever and chills, sweating, body aches, headache, bone pain, muscle pa...

Examples

Embodiment 1

[0046] Embodiment 1, buccal tablet

[0047] Gangmei 490g Iron clad gold 490g Rose apple 490g

[0048] Smelly feces jasmine 196g Pandanus 490g Carboxymethyl cellulose 20g

[0049] Stevioside 50g Micronized silica gel 10g.

[0050] Take the above five-flavored plum, iron-coated gold, rose peach, stinky jasmine and pandanus, add water to decoct twice, 2 hours each time, add 6 times the amount of medicinal materials each time, combine the extracts, concentrate, add 95% medicinal ethanol is a solution with an alcohol content of 70%, standing for 24 hours, filtering, concentrating the filtrate, drying, pulverizing into fine powder, adding auxiliary materials, mixing and granulating to make 1000 tablets.

Embodiment 2

[0051] Embodiment 2, buccal tablet

[0052] Gangmei 490g Iron clad gold 490g Rose apple 490g

[0053] Smelly feces jasmine 196g Pandanus 490g Carboxymethyl cellulose 20g

[0054] Stevioside 50g Micronized silica gel 10g.

[0055] Take the above five-flavored plum, iron-coated gold, rose peach, stinky jasmine and pandanus, and use 95% ethanol to reflux extract twice, add 10 times the amount for the first time, reflux extraction for 2 hours, filter, and dregs for the second time Add 8 times the amount, reflux extraction for 1 hour, filter, combine the filtrates, recover ethanol under reduced pressure until there is no alcohol smell, combine the extracts, filter, and concentrate the filtrate to a thick paste with a density of 1.15-1.20 (60°C thermal measurement), add Excipients are mixed and granulated to make 1000 tablets.

Embodiment 3

[0056] Embodiment 3, comprehensive curative effect evaluation:

[0057] Test group: buccal tablets of Examples 1 and 2 of the present invention;

[0058] Existing granule control group: Shiqi Waigan Granules, produced by Zhongshan Hengsheng Pharmaceutical Co., Ltd., Z44020184. Specifications: 10g per bag, batch number: 20071201,

[0059] METHODS: Random blind method and positive drug parallel control were adopted.

[0060] Course of treatment: 3 days.

[0061] Dosing regimen: (1) Test group: 3 tablets each time, 3 times a day; (2) Control group: 2 bags each time, 3 times a day.

[0062] The test results are as follows:

[0063] Comprehensive curative effect evaluation standard

[0064] Recovery: within 3 days of treatment, the body temperature returned to normal, and the symptoms and signs of colds decreased by ≥90%;

[0065] Significantly effective: within 3 days of treatment, the body temperature is normal, and the symptoms and signs of colds are reduced by ≥70%, <90%;...

technical field

[0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine buccal tablet for treating and preventing influenza and a preparation method thereof. Background technique

[0002] Both colds and influenza are caused by viral infections. Since the virus is airborne, it is the nose that bears the brunt. The virus first infects the nasal mucosa and then multiplies continuously, causing inflammation of the nasal mucosa and symptoms such as sneezing, runny nose, and nasal congestion. A common cold refers to a nasal cold, which generally affects the human body only on the respiratory system. All symptoms are related to the nose, such as runny nose, stuffy nose and sore throat, cough, and even fever. It usually heals in a few days. Influenza is caused by influenza virus. Influenza symptoms affect the whole body, including fever and chills, sweating, body aches, headache, bone pain, muscle pa...

Examples

Embodiment 1

[0046] Embodiment 1, buccal tablet

[0047] Gangmei 490g Iron clad gold 490g Rose apple 490g

[0048] Smelly feces jasmine 196g Pandanus 490g Carboxymethyl cellulose 20g

[0049] Stevioside 50g Micronized silica gel 10g.

[0050] Take the above five-flavored plum, iron-coated gold, rose peach, stinky jasmine and pandanus, add water to decoct twice, 2 hours each time, add 6 times the amount of medicinal materials each time, combine the extracts, concentrate, add 95% medicinal ethanol is a solution with an alcohol content of 70%, standing for 24 hours, filtering, concentrating the filtrate, drying, pulverizing into fine powder, adding auxiliary materials, mixing and granulating to make 1000 tablets.

Embodiment 2

[0051] Embodiment 2, buccal tablet

[0052] Gangmei 490g Iron clad gold 490g Rose apple 490g

[0053] Smelly feces jasmine 196g Pandanus 490g Carboxymethyl cellulose 20g

[0054] Stevioside 50g Micronized silica gel 10g.

[0055] Take the above five-flavored plum, iron-coated gold, rose peach, stinky jasmine and pandanus, and use 95% ethanol to reflux extract twice, add 10 times the amount for the first time, reflux extraction for 2 hours, filter, and dregs for the second time Add 8 times the amount, reflux extraction for 1 hour, filter, combine the filtrates, recover ethanol under reduced pressure until there is no alcohol smell, combine the extracts, filter, and concentrate the filtrate to a thick paste with a density of 1.15-1.20 (60°C thermal measurement), add Excipients are mixed and granulated to make 1000 tablets.

Embodiment 3

[0056] Embodiment 3, comprehensive curative effect evaluation:

[0057] Test group: buccal tablets of Examples 1 and 2 of the present invention;

[0058] Existing granule control group: Shiqi Waigan Granules, produced by Zhongshan Hengsheng Pharmaceutical Co., Ltd., Z44020184. Specifications: 10g per bag, batch number: 20071201,

[0059] METHODS: Random blind method and positive drug parallel control were adopted.

[0060] Course of treatment: 3 days.

[0061] Dosing regimen: (1) Test group: 3 tablets each time, 3 times a day; (2) Control group: 2 bags each time, 3 times a day.

[0062] The test results are as follows:

[0063] Comprehensive curative effect evaluation standard

[0064] Recovery: within 3 days of treatment, the body temperature returned to normal, and the symptoms and signs of colds decreased by ≥90%;

[0065] Significantly effective: within 3 days of treatment, the body temperature is normal, and the symptoms and signs of colds are reduced by ≥70%, <90%;...