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Gynecopathy external use washing lotion and preparation method thereof

A lotion and gynecological technology, which is applied in the field of pharmaceutical composition and its preparation, can solve the problems of long extraction time, easy-to-destroy active ingredients, skin irritation, etc., and achieve the effect of short time, environmental protection and good effect

Active Publication Date: 2011-10-05
PROZIN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the similar medicines for the treatment of vaginitis are mainly western medicines, some of which have a certain stimulating effect on the skin and are not suitable for some people. Effective ingredients, the extraction takes a long time, consumes energy, and decoction is also easy to destroy the active ingredients that are unstable when exposed to heat, and the extraction rate is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 12g of Chinese herbal medicines Nudehuazizhu, 12g of Senecio, 20g of Sophora flavescens, 12g of Baibu, 7g of Kochia, and 12g of Cnidium, crush them through a 40-mesh sieve, add 900ml of water and soak for 1.5 hours. Then, extract at an ultrasonic frequency of 40 kHz for 40 min, and filter to obtain an extract once. Add 750ml of water to the filter residue, repeat the extraction for 20min at an ultrasonic frequency of 40kHz, filter to obtain a second extract, combine the two filtrates, and concentrate to about 1000ml under reduced pressure. Prepare the concentrated solution with 95% ethanol so that the ethanol concentration is 70%, and precipitate with alcohol for 24 hours. Filter the ethanol solution, recover the ethanol in the filtrate, and obtain 1000 ml of water extraction concentrate.

[0039] Extract the concentrate from the above water, dilute to 8000ml with purified water, boil and let cool. Then take 8g of natural borneol, 15g of chlorhexidine acetate and...

Embodiment 2

[0041] Take 8g of Chinese herbal medicines Nadihuazizhu, 9g of Senecio, 12g of Sophora flavescens, 8g of Baibu, 5g of Kochia, and 8g of Cnidium, crush them through a 50-mesh sieve, add 700ml of water and soak for 2 hours. Then, extract at an ultrasonic frequency of 50 kHz for 30 min, and filter to obtain an extract once. Add 600ml of water to the filter residue, repeat the extraction for 15min at an ultrasonic frequency of 50kHz, filter to obtain a second extract, combine the two filtrates, and concentrate to about 800ml under reduced pressure. Prepare the concentrated solution with 92% ethanol to make the ethanol concentration 60%, and alcohol precipitation for 20 hours. Filter the ethanol solution, recover the ethanol in the filtrate, and obtain 800 ml of water extraction concentrate.

[0042] Extract the concentrate from the above water, dilute to 5600ml with pure water, boil and let cool. Then take 5.5g of natural borneol, 12g of chlorhexidine acetate and about 0.7g of e...

Embodiment 3

[0044] Take 1.2g of the Chinese herbal medicines Nudehuazizhu, 1.2g of Senecio, 2.0g of Sophora flavescens, 1.2g of Baibu, 0.7g of Kochia, and 1.2g of Cnidium, crush them through a 30-mesh sieve, add 75ml of water and soak for 1 hour. Then, extract at an ultrasonic frequency of 30 kHz for 50 min, and filter to obtain an extract once. Add 60ml of water to the filter residue, repeat the extraction for 25min at an ultrasonic frequency of 30kHz, filter to obtain a second extract, combine the two filtrates, and concentrate to about 100ml under reduced pressure. Prepare the concentrated solution with 99% ethanol to make the ethanol concentration 70%, and alcohol precipitation for 28 hours. Filter the ethanol solution, recover the ethanol in the filtrate, and obtain 100 ml of water extraction concentrate.

[0045] Dilute the above water extract concentrate to 1000ml with pure water, boil and let cool. Then take 0.8g of natural borneol, 1.5g of chlorhexidine acetate and about 0.1g o...

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Abstract

Disclosed is a gynecopathy external use washing lotion and a preparation method thereof. The invention relates to a pharmaceutical composition and a preparation method thereof. The washing lotion contains the following components: Callicarpa nudiflora, senecio, radix sophorae falvescentis, stemona, broom cypress fruit, common cnidium fruit, borneol, chlorhexidine acetate and essence. The preparation method comprises the steps of extraction of the above-mentioned components, alcohol precipitation and preparation. The beneficial effects of the invention are as follows: the washing lotion prepared in the invention has no side effects to human bodies and shows good effects on sterilization and detoxification; a small quantity of safe and effective western medicinal components are used as accessories to the washing lotion, which endows the washing location with characteristics of safety, rapidness and efficiency. The preparation method provided in the invention abandons the conventional process of hot reflux extraction of traditional Chinese medicinal materials and has the advantages of a short preparation time, low energy consumption and high extraction efficiency, and is favorable for protecting environment and saving cost.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating gynecological diseases and a preparation method thereof. Background technique [0002] With the development of the economy, the improvement of people's living standards, and the enhancement of people's awareness of health care, women are paying more and more attention to their own health. Gynecological diseases are natural enemies of women's health. 90% of adult women have gynecological diseases to varying degrees. Vaginitis is a common and frequently-occurring disease in gynecological diseases. The rate is 75%, and about half of the women experience multiple recurrences, mainly manifested as symptoms such as vulvar and vaginal itching, redness, and increased leucorrhea. It affects women's work and sleep, brings great inconvenience to life, and will be infected with each other, bringing serious consequences...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61P15/02A61K31/045A61K31/155
Inventor 肖军平吴永忠郭峰李旭刘立鼎
Owner PROZIN PHARMA CO LTD
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