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Prulifloxacin tablets and preparation process thereof

A technology of prulifloxacin and tablet, applied in the field of prulifloxacin tablet and its preparation technology, can solve the problems of low dissolution rate and high bioavailability of ordinary tablet

Active Publication Date: 2011-10-12
NANJING CHANGAO PHARMA SCI & TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The inventor finds that the dissolution rate of Prulifloxacin Compound Tablets and Prulifloxacin Dispersible Tablets in the existing patent application is low through a large number of experimental studies, and the dissolution rate of the Prulifloxacin Orally Disintegrating Tablet in the Patent Application is relatively low. High, but its bioavailability of ordinary tablets without gastrointestinal absorption is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] prescription:

[0044] Prulifloxacin 132g

[0045] Sodium carbonate 10g

[0046] Lactose 10g

[0047] Microcrystalline Cellulose 40g

[0048] Low-substituted hydroxypropyl cellulose 10g

[0049] Magnesium Stearate 1.5g

[0050]

[0051] Makes 1000 pieces

[0052] Preparation Process:

[0053] Prulifloxacin was dried under reduced pressure at around 45°C for 4 hours, all auxiliary materials were dried at 60°C for 3 hours, and the raw and auxiliary materials were passed through an 80-mesh sieve. After calculating the dosage according to the prescription quantity, weigh the raw and auxiliary materials, mix prulifloxacin and sodium carbonate evenly, and set aside, mix lactose, microcrystalline cellulose and low-substituted hydroxypropyl cellulose evenly, and mix the above two kinds of powder Mix evenly, and granulate with a dry granulator (18 mesh sieve for granulation). Lubricant magnesium stearate is added and the granules are ev...

Embodiment 2

[0055] prescription:

[0056] Prulifloxacin 132g

[0057] Sodium bicarbonate 20g

[0058] Lactose 10g

[0059] Microcrystalline Cellulose 50g

[0060] Low-substituted hydroxypropyl cellulose 10g

[0061] Magnesium Stearate 1.5g

[0062]

[0063] Makes 1000 pieces

[0064] The specific preparation process is the same as in Example 1.

Embodiment 3

[0066] prescription:

[0067] Prulifloxacin 100g

[0068] Potassium bicarbonate 5g

[0069] Lactose 10g

[0070] Microcrystalline Cellulose 60g

[0071] Low-substituted hydroxypropyl cellulose 5g

[0072] Magnesium Stearate 1.5g

[0073]

[0074] Makes 1000 pieces

[0075] The specific preparation process is the same as in Example 1.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and relates to prulifloxacin tablets and a preparation process thereof. The prulifloxacin tablet contains an active component prulifloxacin or a pharmaceutical salt thereof, as well as a carbonate alkaline substance and pharmaceutically acceptable additives. The prulifloxacin tablets can be obtained by direct power tabletting or wet method granulation tabletting, and adopt a thin-film coating mode. In the prulifloxacin tablets, the medicament stability is greatly improved, the solubility of the medicament is increased, and the bitter taste of the medicament can be effectively covered.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a prulifloxacin tablet and a preparation process thereof. Background technique [0002] Infectious disease is the most common clinical disease, involving almost all clinical specialties, and it is also one of the most common causes of patient death. According to the report of the World Health Organization in 1997, the number of deaths from infectious diseases was as high as 33.3% of the total number of deaths from various causes. [0003] Anti-infective drugs are a powerful weapon for human beings to fight against infectious diseases. They are the largest in number, most in variety, and fastest growing, and the market demand for drugs in this area has always been very strong. According to statistics, the sales of anti-infective drugs account for the world's drug sales, second only to cardiovascular drugs. In my country, anti-infective drugs account for the market share of the entire drug s...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/36A61K31/496A61K47/02A61P31/04
Inventor 何红燕谢晓燕张自强吴小涛黄海燕朱丽君
Owner NANJING CHANGAO PHARMA SCI & TECH CO LTD
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