Formula of soft capsule shell

A technology of soft capsules and capsule shells, which is applied in the new technology field of soft capsule sols in the pharmaceutical industry, and can solve problems such as oil leakage, liquid leakage, and slow disintegration

Inactive Publication Date: 2011-10-26
贵州地道药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a new formula for soft capsule shells, solve the problems of soft capsule quality insecurity, slow disintegration, seepage, and differences in loading during the stable period, overcome the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1:

[0025] (1) put into purified water: 80kg, glycerin: 30kg, sorbitol: 20kg, PEG-400: 9kg, close the feeding port, open stirring, the temperature of the mixed solution is raised to 62 ℃, and the entire sol process keeps the interlayer water temperature at 60 ℃~80℃.

[0026] (2) Slowly add 90kg of gelatin into the sol tank while stirring, and control the speed of gelling to avoid gelatin agglomeration and affect the gelatinization effect. After the glue injection is completed, close the feeding port and lock it, and open the vacuum pump to vacuumize the negative pressure sol.

[0027] (3) During the sol process, observe the situation in the tank and the changes in temperature and pressure at all times to prevent the glue from being drawn away. After the pressure reaches -0.06Mpa, turn off the vacuum pump and maintain this negative pressure for 45 minutes. Break the vacuum to observe that the gelatin has completely dissolved.

[0028] (4) Add 0.9kg of fumari...

Example Embodiment

[0030] Example 2:

[0031] (1) put into purified water: 80kg, glycerin: 28kg, sorbitol: 22kg, PEG-400: 10kg, close the feeding port, open stirring, the temperature of the mixed solution is raised to 64 ° C, and the temperature of the interlayer water is kept at 60 °C throughout the sol process. ℃~80℃.

[0032] (2) Slowly add 100kg of gelatin into the sol tank while stirring, and control the speed of gelling to prevent gelatin from agglomerating and affecting the gelatinization effect. After the glue injection is completed, close the feeding port and lock it, and open the vacuum pump to vacuumize the negative pressure sol.

[0033] (3) During the sol process, observe the situation in the tank and the changes in temperature and pressure at all times to prevent the glue from being drawn away. After the pressure reaches -0.06Mpa, turn off the vacuum pump and maintain this negative pressure for 42 minutes. Break the vacuum to observe that the gelatin has completely dissolved.

...

Example Embodiment

[0036] Example 3:

[0037] (1) put into purified water: 90kg, glycerin: 35kg, sorbitol: 15kg, PEG-400: 10kg, close the feeding port, open stirring, and the temperature of the mixed solution is raised to 60 ° C, and the entire sol process keeps the interlayer water temperature at 60 °C ℃~80℃.

[0038] (2) Slowly add 100kg of gelatin into the sol tank while stirring, and control the speed of gelling to prevent gelatin from agglomerating and affecting the gelatinization effect. After the glue injection is completed, close the feeding port and lock it, and open the vacuum pump to vacuumize the negative pressure sol.

[0039] (3) During the sol process, observe the situation in the tank and the changes in temperature and pressure at all times to prevent the glue from being drawn away. After the pressure reaches -0.06Mpa, turn off the vacuum pump and maintain this negative pressure for 46 minutes. Break the vacuum to observe that the gelatin has completely dissolved.

[0040] (4...

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PUM

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Abstract

The invention relates to a formula of a soft capsule shell, which comprises gelatin, water, glycerol and sorbitol. The formula is characterized in that the proportion of a plasticizer (namely glycerol) and sorbitol is adjusted, and the components are as follows by weight percentage: gelatin 80-100%, water 60-80%, plasticizer 40-60%, antioxidant 0.2-1.2%, and PEG-400 (polyethylene glycol-400) 5-15%. Due to high requirements of soft capsules for the plasticity of shell materials, the moisturizing property of sorbitol is considered and the shell is ensured not to cause softening, deformation, adhesion, liquid leakage and other problems of the soft capsule due to excessive water content, so that the plasticizer is mixed for use to ensure the stability of the capsule. The antioxidant can prevent crosslinking due to oxidation reactions among the substances in the shell material, so as to cause time delay in disintegration of the soft capsule. The addition of the antioxidant in the formula provided by the invention can effective inhibit oxidation, so as to ensure the disintegration of the soft capsule and improve the quality of the shell material.

Description

Technical field: [0001] The invention relates to a new formula of a soft capsule shell, in particular to a new technology of soft capsule sol in the pharmaceutical industry. Background technique: [0002] Soft capsules refer to capsules in which medicinal material extracts, liquid medicines, or appropriate auxiliary materials are mixed and sealed in soft capsules by dripping or pressing. Compared with other traditional Chinese medicine forms, it has the advantages of high content of active ingredients, high bioavailability, rapid absorption, good stability, can cover the bad smell of volatile components of traditional Chinese medicine, less dosage, beautiful appearance and easy to carry, etc., so it is becoming more and more popular. By the attention of the pharmaceutical industry. The traditional capsule material formula mainly includes gelatin, water, glycerin and selected pigments. The capsule material made is made into soft capsules, and the quality is not guaranteed. ...

Claims

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Application Information

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IPC IPC(8): A61K9/48
Inventor 路祖强
Owner 贵州地道药业有限公司
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