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A single traditional Chinese medicine anti-inflammatory, cough-relieving and expectorant aerosol and preparation method thereof

An antitussive, expectorant, and aerosol technology, applied in aerosol delivery, pharmaceutical formulations, drug combinations, etc.

Inactive Publication Date: 2011-12-14
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report of a single traditional Chinese medicine anti-inflammatory, antitussive, and expectorant aerosol product mainly composed of volatile oil of Fujian wing stem fragrant green at home and abroad. This product has a broad market and application prospects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] 1. The whole herb of the winged stem, crushed into 20 meshes, 85% ethanol as the extraction solvent, extracted at 80°C for 1.5-2.0 h, cooled by circulating water to ethanol vapor to obtain volatile oil, collected volatile oil,

[0011] 2. Aerosol formula: 15% of the volatile oil of Cymbidium chinensis, 22% of ethanol, 2.844% of propylene glycol, 0.15% of vitamin C, 60% of propellant, and 0.006% of borneol.

[0012] 3. Dissolve vitamin C and borneol in ethanol first, then fully miscible with the volatile oil and propylene glycol of the wing stem, pack it in an aerosol container, fill it with propellant, shake it well, and it is an aerosol for anti-inflammatory, cough-relieving and expectorant.

Embodiment 2

[0014] 1. The whole herb of Pteris chinensis, crushed into 30 meshes, 95% ethanol as the extraction solvent, extracted at 85°C for 1.5-2.0 h, cooled by circulating water with ethanol vapor to obtain volatile oil, collected volatile oil,

[0015] 2. Aerosol formula: 20% of the volatile oil of Cymbidium chinensis, 15% of ethanol, 3.79% of propylene glycol, 0.2% of vitamin C, 61% of propellant, and 0.01% of borneol.

[0016] 3. Dissolve vitamin C and borneol in ethanol first, then fully miscible with the volatile oil and propylene glycol of the wing stem, pack it in an aerosol container, fill it with propellant, shake it well, and it is an aerosol for anti-inflammatory, cough-relieving and expectorant.

Embodiment 3

[0018] 1. The whole herb of Pteris chinensis, crushed into 40 meshes, 96% ethanol as the extraction solvent, extracted at 90°C for 1.5-2.0 h, cooled by circulating water to ethanol vapor to obtain volatile oil, collected volatile oil,

[0019] 2. Aerosol formula: 25% of the volatile oil of Cymbidium chinensis, 15% of ethanol, 4.735% of propylene glycol, 0.25% of vitamin C, 55% of propellant, and 0.015% of borneol.

[0020] 3. Dissolve vitamin C and borneol in ethanol first, then fully miscible with the volatile oil and propylene glycol of the wing stem, pack it in an aerosol container, fill it with propellant, shake it well, and it is an aerosol for anti-inflammatory, cough-relieving and expectorant.

[0021] volatile oil GC-MS analyze:

[0022] We isolated 66 components from the volatile oil of Cymbidium chinensis, and identified 59 substances, accounting for 85.58% of the total substances. Most of these substances are monoterpenes and sesquiterpenes, and their oxygenated ...

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Abstract

The invention provides an inflammation-diminishing, cough-relieving and phlegm-eliminating aerosol containing a single traditional Chinese medicine. The inflammation-diminishing, cough-relieving and phlegm-eliminating aerosol comprises: by weight, 15 to 25% of anasphalis sinica hance form.peterocaula(Franch.et savat.)ling essential oil, 15 to 22% of ethanol, 2.5 to 5% of propylene glycol, 0.10 to0.25% of vitamin C, 55 to 61% of propellent and 0.006 to 0.01% of borneol. A preparation method of the inflammation-diminishing, cough-relieving and phlegm-eliminating aerosol containing a single traditional Chinese medicine comprises the following steps of dissolving vitamin C and borneol in ethanol, mixing the mixture obtained by the previous step, anasphalis sinica hance form.peterocaula(Franch.et savat.)ling essential oil and propylene glycol to dissolve fully, putting separately the mixture obtained by the previous step into aerosol containers, filling the propellent into the aerosol containers, and shaking up to obtain the desired product. The inflammation-diminishing, cough-relieving and phlegm-eliminating aerosol adopts anasphalis sinica hance form.peterocaula(Franch.et savat.)ling essential oil as a main ingredient and has multiple effects of inflammation diminishing, cough and asthma relieving, phlegm eliminating, pharynx clearing and throat nourishing. The inflammation-diminishing, cough-relieving and phlegm-eliminating aerosol can enter into a human body through the respiratory tract and thus the inflammation-diminishing, cough-relieving and phlegm-eliminating aerosol can be directly transported to a lesion. Therefore, the inflammation-diminishing, cough-relieving and phlegm-eliminating aerosol has a less use amount, produces effects fast and can bring double effects. An aerosol dose is low. Carrying is easy. Use is convenient.

Description

Background technique [0001] Wing Stem Xiangqing ( Anaphalis sinica Hance from. pterocaula (Franch. et savat.) Ling), which belongs to the whole herb of the genus Asteraceae of the genus Asteraceae, also known as the white four-edged front, sweetgum, perennial herb with special fragrance, born in high mountains and hilly areas, mainly distributed in my country In southeast Jiangsu, Zhejiang, Fujian, southern Gansu, eastern Qinghai, southern Shaanxi and northwestern Sichuan and other provinces and regions. The wing stems are fragrant and cool in nature, enter the lungs and large intestine meridians, have antitussive, expectorant, antiasthmatic and anti-inflammatory effects, and can be used to treat diseases such as wind-cold cold, acute and chronic bronchitis, dysentery and enteritis, especially for bronchitis. clinical effect. At present, there is no report of a single traditional Chinese medicine anti-inflammatory, antitussive, and expectorant aerosol product with the m...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K9/12A61P11/00A61P11/06A61P11/10A61P11/14A61K31/375A61K31/045
Inventor 魏道智宁书菊刘薇
Owner FUJIAN AGRI & FORESTRY UNIV
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