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Water-soluble nano composite material and preparation method and use thereof

A technology of nano-composite materials and water-soluble materials, which can be used in pharmaceutical formulations, preparations for in vivo tests, and contrast agents for nuclear magnetic resonance/magnetic resonance imaging, etc. technical problems, to achieve the effect of easy industrial production, simplified preparation method and good controllability

Active Publication Date: 2012-01-25
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the water solubility, stability, targeting and biocompatibility of gadolinium and SPION materials have been improved by improving the structure of gadolinium and SPION materials, the sensitivity and specificity of single-mode contrast agents are still not high enough for MPI diagnostic techniques. Difficult to break through, in order to overcome the defects of the single-mode medical detection method of MRI diagnostic technology, MRI diagnostic technology can be combined with CT diagnostic technology to obtain clear images of any section of human tissue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1 PAMAM-Ag / Gd 2 o 3 Preparation of water-soluble nanocomposites

[0060] Get the polyamidoamine-silver (PAMAM-Ag) aqueous solution of 100mL 3mmol / L (the preparation method reference of polyamidoamine-silver material " Hui Liu, Han Wang, Rui Guo, et al., Size-controlled synthesis of dendrimer- stabilized silver nanoparticles for X-ray computed tomography imaging applications, Polym.Chem., 2010, 1, 1677-1683"), and then add 5 mL of nano-Gd with a concentration of 1 mmol / L 2 o 3 Aqueous solution (water-soluble nano Gd 2 o 3 The preparation method reference "M.-A.Fortin, R.M.Petoral, Jr, F. et al., Polyethylene glycol-covered ultra-small Gd 2 o 3 Nanoparticles for positive contrast at 1.5 T magnetic resonance clinical scanning Nanotechnology 2007, 18, 395501" or a Chinese patent application with publication number CN 101018568A), stirred at room temperature for 3 hours at 25°C to obtain PAMAM-Ag / Gd 2 o 3 Water-soluble nanocomposites. Appropriate amount o...

Embodiment 2

[0061]Embodiment 2 Iohexol / Fe 3 o 4 Preparation of water-soluble nanocomposites

[0062] Get commercially available iohexol (iohexol injection, Ningbo Tianheng Pharmaceutical Co., Ltd.) 10mg and dissolve it in 100mL water to obtain an iohexol aqueous solution, then add 10mL of 10mmol / L FeCl to the iohexol aqueous solution dropwise. 3 aqueous solution and 10 mL of 20 mmol / L FeCl 2 Aqueous solution, using 1mol / L ammonia solution to adjust the pH value of the solution to 6.50 to obtain a mixed solution, the above mixed solution was hydrolyzed at room temperature at 25°C for 3h in a normal system to obtain iohexol / Fe 3 o 4 Water-soluble nanocomposites. Appropriate amount of Fe 3 o 4 It is stably bound to the surface of iohexol through hydrogen bonds and other forces to form a composite structure that is completely or incompletely covered. Among them, iohexol is used as a CT contrast component, and Fe 3 o 4 Nanoparticles as MRI-T 2 Contrast component, the iohexol / Fe 3 o ...

Embodiment 3

[0063] Example 3 Au / Fe 3 o 4 Preparation of water-soluble nanocomposites

[0064] Take 100mL of freshly prepared 5mmol / L gold (Au) nanoparticle solution (preparation method of gold nanoparticle solution reference "Chie Kojima, Yasuhito Umeda, Mikako Ogawa, et al., X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer.2010, Nanotechnology, 21, 245104"'), add 0.1mL 5mmol / L cysteine ​​aqueous solution and stir for 12h for surface modification, use 0.1mol / L sodium hydroxide aqueous solution to adjust the solution pH to 6.50, forming a stable Au-S chemical bond. Then 10 mL of 10 mmol / L FeCl was added dropwise 3 aqueous solution and 10 mL of 20 mmol / L FeCl 2 Aqueous solution, the above solution is hydrolyzed at room temperature 25°C for 3h in a normal system to obtain Au / Fe 3 o 4 Water-soluble nanocomposites. Formed Fe 3 o 4 Nanoparticles are stably combined on the surface of gold nanoparticles through hydrogen bond...

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Abstract

The invention discloses a preparation method of a water-soluble nano composite material. The water-soluble nano composite material with a composite structure having a medical resonance imaging (MRI) contrastographic function and a computed tomography (CT) contrastographic function is obtained by utilizing water-soluble material having a CT contrastographic function or a water-soluble material having an MRI contrastographic function through the action of chemical agent and reaction agent, and the composite structure is a structure which is formed through electrostatic adherence or chemical bonding connection of the water-soluble material having the CT contrastographic function and the water-soluble material having the MRI contrastographic function. The preparation method has the advantages of simplicity in preparation, good controllability, high productivity, easiness in industrialized production and the like. The invention also discloses a water-soluble nano composite material which is prepared through the above method, which has the advantages of good water solubility, stable structural performance, good biological compatibility, sensitivity and accuracy in CT / MRI radiography and the like, is suitable for being used as CT / MRI double-mode medical contrast medium, and is particularly suitable for the double-mode medical imaging examination of tumor cells.

Description

technical field [0001] The invention relates to the field of preparation and application of a nano-composite material with imaging function, in particular to a water-soluble nano-composite material with CT / MRI dual-mode imaging function and its preparation method and application. Background technique [0002] With the application of medical imaging technology in cancer detection and diagnosis, magnetic resonance imaging (MRI) diagnostic technology has attracted much attention due to its non-invasive, relatively fast and accurate characteristics. The MRI nanomedical contrast agent used in conjunction with nuclear magnetic resonance imaging diagnostic technology can interact with different biological tissues to present corresponding magnetic resonance signals under the action of an external magnetic field. Differential classification, can be divided into T 1 and T 2 contrast agent. At present, the MRI medical contrast agents marketed at home and abroad are based on T 1 Gad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06A61K49/10A61K49/12A61K49/14
Inventor 张颖鑫吴爱国聂秀青
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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