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Novel blood rheology quality control composition comprising ester compound

A technology of ester compounds and compositions, which is applied in the field of blood rheological index detection, can solve the problems of long-term stability and rheological reproducibility to be confirmed, and achieve the effect of changing rheological properties and good correspondence

Inactive Publication Date: 2012-01-25
SHENZHEN SYDSCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the long-term stability and rheological reproducibility of the above technical solutions have yet to be confirmed

Method used

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  • Novel blood rheology quality control composition comprising ester compound
  • Novel blood rheology quality control composition comprising ester compound
  • Novel blood rheology quality control composition comprising ester compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1), preparation of hemorheological quality control composition containing 0.1% diethyl phthalate 1

[0034] Add 0.1g of diethyl phthalate to 99.9g of plasma, in which the plasma is anticoagulated with heparin sodium at a concentration of 0.1mg / ml, and 0.1ml of sodium azide is used as a preservative. , 5ml per tube, stored at -20°C.

[0035] (2), whole blood / plasma viscosity and composition 1 fitting experiment

[0036] Take normal blood samples, adjust the hematocrit to 42%, measure for 10, 60, 150s -1 The whole blood apparent viscosity and plasma viscosity within the range of the shear rate are compared with the viscosity curve of composition 1. The change curve of plasma and composition 1 viscosity with shear rate is as follows figure 1 Shown, where the unit of shear rate is s -1 , the viscosity unit is: mPa.s, figure 1 The curve marked with "□" is the plasma viscosity change curve, and the one marked with "○" is the viscosity change curve of composition 1. fro...

Embodiment 2

[0046] (1), preparation of hemorheological quality control composition containing 0.2% dioctyl sebacate 2

[0047] Add 0.2 g of dioctyl sebacate to 99.8 g of serum, in which the serum is anticoagulated with heparin with a concentration of 0.1 mg / ml, and 0.1 ml of sodium azide is used as a preservative. Tube 5ml, store at -20°C.

[0048] (2), whole blood / serum viscosity and composition 2 fitting experiment

[0049] Take normal blood samples, adjust the hematocrit to 42%, measure for 10, 60, 150s -1 The whole blood apparent viscosity and serum viscosity within the range of the shear rate are compared with the viscosity curve of composition 2 for fitting degree. The comparison results showed that the serum viscosity did not change with the shear rate, but the apparent viscosity of the composition 2 containing 0.2% dioctyl sebacate decreased with the increase of the shear rate, showing a non-Newtonian fluid.

[0050] in 10s -1 The apparent viscosity is the initial viscosity, a...

Embodiment 3

[0059] (1), preparation of blood rheological quality control composition 3 containing 40% polyoxyethylene sorbitan fatty acid ester--Tween 80

[0060] Add 40g of Tween 80 to 60g of plasma. The plasma is anticoagulated with 0.1mg / ml heparin and 0.1ml of sodium azide as preservative. -20°C environment.

[0061] (2), whole blood / plasma viscosity and composition 3 fitting experiment

[0062] Take normal blood samples, adjust the hematocrit to 42%, measure for 10, 60, 150s -1 The whole blood apparent viscosity and plasma viscosity within the range of the shear rate are compared with the viscosity curve of composition 3 for fitting degree. The comparison results showed that the plasma viscosity did not change with the shear rate, but the apparent viscosity of the composition 3 containing 40% Tween 80 decreased with the increase of the shear rate, showing a non-Newtonian fluid.

[0063] in 10s -1 The apparent viscosity is the initial viscosity, and the apparent viscosity and the ...

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Abstract

A novel blood rheology quality control composition comprising ester compound is composed of 60-99.99 weight percent of first component and 0.01-40 weight percent of second component. The first component is blood plasma or blood serum, the second component is ester compound, the two components constitute non-Newtonian fluid, and the expression viscosity is directly proportional to the shear rate.

Description

technical field [0001] The invention relates to blood rheology index detection technology in the field of medical diagnosis, and more specifically relates to a novel blood rheology quality control composition containing ester compounds. Background technique [0002] The most basic indicators of macroscopic clinical hemorheology testing should include the determination of whole blood viscosity, plasma viscosity, hematocrit and plasma fibrinogen. Blood is a complex non-Newtonian fluid whose apparent viscosity varies with shear rate and shear time. The quality control of hemorheology testing is quite complicated, and due to the lack of standard reference materials, the clinical data of hemorheology detected by different hospitals and instruments are not comparable, which affects the clinical application of hemorheology testing. Therefore, developing a suitable hemorheological quality control substance is a problem concerned by those skilled in the art. [0003] Some related s...

Claims

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Application Information

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IPC IPC(8): G01N11/00
CPCG01N11/00G01N33/96
Inventor 刘牧龙张文阁修宏宇王艳平
Owner SHENZHEN SYDSCI TECH
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