Cement for filling bones

A bone cement, cement technology, applied in surgical adhesive, application, medical science and other directions, can solve problems such as preparation difficulties

Active Publication Date: 2015-07-08
TEKNIMED SAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adding a fourth component to the formulation only makes it more difficult to prepare

Method used

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  • Cement for filling bones
  • Cement for filling bones
  • Cement for filling bones

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Example 1: Binary composition with 13 wt% gelatin based on powder weight (10 wt% gelatin based on cement weight)

[0080] Powder phase (weight%)

[0081]

[0082]

[0083] Liquid phase (weight%)

[0084] MMA 99

[0085] DMPT 1

[0086] HQ 20ppm

[0087] Among them, P / L=3.4

[0088] Final Young's modulus = 1000MPa

Embodiment 2

[0089] Example 2: Binary composition with 25% gelatin by weight of powder (20% gelatin by weight of cement)

[0090] Powder phase (weight%)

[0091]

[0092] Liquid phase (weight%)

[0093] MMA 99

[0094] DMPT 1

[0095] HQ 20ppm

[0096] Among them, P / L=4

[0097] Final Young's modulus = 500MPa

Embodiment 3

[0098] Example 3: Method of preparing bone cement with suitable stiffness

[0099] ·Powder composition:

[0100] The powder phase is obtained by mixing the ingredients.

[0101] ·Liquid components:

[0102] The liquid phase was prepared by dissolving hydroquinone in methyl methacrylate monomer. Keep stirring until completely dissolved. Then add DMPT.

[0103] The two phases are packaged separately in containers suitable for their storage. The ready-to-use kit comprises a container containing said liquid phase and a container containing said powder phase.

[0104] · Binary composition

[0105] During use in the operating room, the containers are opened and their contents mixed together. The powder dissolves rapidly in the liquid phase to obtain a fluid mixture which is injected through a suitable catheter into the patient's vertebral body. The BPO initiator and DMPT activator react to form free radicals that initiate polymerization of the cement. The surgeon then has at ...

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Abstract

The invention relates to an injectable bone cement for filling bones, having mechanical properties equivalent to those of the vertebral spongy bone, and containing 70 to 99 wt % of an acrylic polymer combined with a radio-opaque inorganic compound and 1 to 30 wt % of calibrated hydrophilic flexible solid particles capable of absorbing physiological fluids without generating interconnected porosity, said calibrated hydrophilic flexible solid particles being selected from gelatine, polyglycerol(sebacate), or a mixture thereof. The bone cement of the invention is in particular intended for vertebroplasty, kyphoplasty or cementoplasty.

Description

technical field [0001] The present invention relates to the field of polymeric cements, particularly acrylic cements, for repairing bone and joint wounds. Background technique [0002] The object of the present invention is to provide a fluid cement for medical use having mechanical properties suitable for filling cancellous bone tissue, and a binary composition intended for the preparation of such a cement. [0003] Bone cements have been used for many years to facilitate the fixation of artificial implants to the framework. A cement used as a link between bone and implant must meet a number of requirements. Specifically, it must be non-toxic and biocompatible. Even some cements have been studied for their bioactive properties, ie their effect on promoting adhesion and cell growth on implants. [0004] Beginning in the mid-1980s, the use of cement has been extended to bone repair, first with percutaneous vertebroplasty. This minimally invasive technique allows cement to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00
CPCA61L27/50A61L2430/02A61L27/16A61L27/48A61L2400/06C08L33/08C08L67/02
Inventor A.伦纳德C.拉弗格尼C.森德B.多纳宗
Owner TEKNIMED SAS
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